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Understanding the Noxious cause of Lou Gehrig's disease
September 14, 2007There is no known cure for amyotrophic lateral sclerosis (ALS), often known as Lou Gehrig disease and motor neuron disease. ALS is a progressive, fatal, neurodegenerative disease caused by the degeneration of nerves that control voluntary muscle movement. New evidence generated in mice by John Engelhardt and colleagues at Iowa University, Iowa City, has provided insight into the mechanisms responsible for certain forms of the disease and has identified potential targets for the development of drugs to treat individuals with these forms of ALS.
In some individuals, ALS is caused by a mutation in their SOD1 gene. Mice overexpressing this mutant gene (SOD1G93A mice) develop ALS-like disease. In this study, the authors found that the rate of disease progression could be dramatically slowed and survival markedly improved if SOD1G93A mice lacked expression of either Nox1 or Nox2, although the effects were more dramatic in the absence of Nox2. The Nox1 and Nox2 genes are on the X-chromosome and female mice lacking just one copy of either gene showed delayed disease onset, indicating that even a 50% decrease in expression of these proteins provided some protection. These data have led to the suggestion that developing drugs to inhibit the Nox pathway might be of benefit to individuals with ALS.
Journal of Clinical Investigation
ALS Current Events and ALS News RSSNew understanding about mechanism for cell death after stroke leads to possible therapy
Scientists at the Brain Research Centre, a partnership of the University of British Columbia Faculty of Medicine and Vancouver Coastal Health Research Institute, have uncovered new information about the mechanism by which brain cells die following a stroke, as well as a possible way to mitigate that damage.
Schizophrenia gene's role may be broader, more potent, than thought
UCSF scientists studying nerve cells in fruit flies have uncovered a new function for a gene whose human equivalent may play a critical role in schizophrenia.
Compound shows potential for slowing progression of ALS
A chemical cousin of a drug currently used to treat sepsis dramatically slows the progression of amyotrophic lateral sclerosis, better known as ALS or Lou Gehrig's disease, in mice.
Dysfunctional protein dynamics behind neurological disease?
Researchers at Lund University, Sweden, have taken a snapshot of proteins changing shape, sticking together and creating structures that are believed to trigger deadly processes in the nervous system.
New guidelines identify best treatments to help ALS patients live longer, easier
New guidelines from the American Academy of Neurology identify the most effective treatments for amyotrophic lateral sclerosis (ALS), often called Lou Gehrig's disease. The guidelines are published in the October 13, 2009, issue of Neurology®, the medical journal of the American Academy of Neurology.
LSUHSC's England plays key role in developing new ALS treatment guidelines
Dr. John England, Professor and Chairman of Neurology at LSU Health Sciences Center New Orleans, analyzed research findings and was responsible for the quality and accuracy of evidence analysis and the conclusions of the studies resulting in new guidelines for treating Lou Gehrig's disease, or amyotropic lateral sclerosis (ALS).
Scientists encouraged by new mouse model's similarities to human ALS
A new mouse model of amyotrophic lateral sclerosis (ALS) closely resembles humans with the paralyzing disorder, researchers at Washington University School of Medicine in St. Louis report.
Amyotrophic lateral sclerosis may involve a form of sudden, rapid aging of the immune system
Premature aging of the immune system appears to play a role in the development of amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, according to research scientists from the Maxine Dunitz Neurosurgical Institute at Cedars-Sinai Medical Center, the Weizmann Institute of Science in Israel, and Sheba Medical Center in Israel.
Michigan Tech Mathematicians Identify Genes Linked to Lou Gehrig's Disease
Michigan Technological University researchers have linked three genes to the most common type of amyotrophic lateral sclerosis (ALS), generally known as Lou Gehrig's disease.
Jet-propelled Imaging for an Ultrafast Light Source
John Spence, a physicist at Arizona State University, is a longtime user of the Advanced Light Source at Lawrence Berkeley National Laboratory, where he has contributed to major advances in lensless imaging.
More ALS Current Events and ALS News Articles
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I Remember Running: The Year I Got Everything I Ever Wanted - and ALS by Darcy Wakefield (Author), Jonathan Eig (Foreword) A little over a year ago, Darcy Wakefield was a single, 33-year-old, athletic, workaholic English professor, a vegetarian who had never had a serious health problem or injury. Then she was diagnosed with ALS, and her world turned upside down. I Remember Running is Darcy's story of change and loss and challenges during her first year with ALS, as she struggles to make sense of her diagnosis and redefine herself in the face of this terminal illness. With unflagging courage, wit, and eloquence, Darcy shares what she calls her "fast-forward" life, a life in which she applies for disability, leaves her job, and plans her own funeral as well as meets and moves in with her true love, buys a house, and gives birth to her first child in less time than it takes most of us to accomplish even one of... |
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I Choose to Live: A Journey Through Life with ALS by William Sinton (Author) |
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So Much So Fast Starring: Stephen Heywood, Jamie Heywood Directed By: Steven Ascher;Jeanne Jordan What would you do if you were 29 and found you may only have a few years to live? So Much So Fast is about the remarkable events set in motion when Stephen Heywood discovers he has ALS (Lou Gehrig's disease) and his brother Jamie becomes obsessed with finding a cure. |
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If They Could Only Hear Me: A collection of personal stories about ALS and the families that have been affected. by Ed Rice (Editor) This collection of personal stories was assembled to help bring more awareness to an insidious disease called amyotrophic lateral sclerosis (ALS), more commonly known as Lou Gehrig’s disease. |
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Amyotrophic Lateral Sclerosis: A Guide for Patients and Families by M.D. Hiroshi Mitsumoto (Editor) This important book covers every aspect of living with ALS, from clinical features of the disease to an overview of symptom management to understanding its diagnosis. Major sections deal with overseeing medical care and rehabilitation, living with ALS, the disease’s advanced phase, end-of-life issues, and resources. Extensively revised and rewritten, this edition contains new chapters on the latest approaches to treating ALS symptoms, the use of noninvasive ventilators, multidisciplinary team care, new guidelines being developed by the American Academy of Neurology for patients with ALS, the use of riluzole (Rilutek), and more. |
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Cast Aluminum Scoop, 5 Ounce (ALS-5) Category: Scoops by Admiral Craft Heavy duty, mirror finish with contoured handles. This aluminum scoop is a quality yet economical kitchen utensil. Whether you're scooping ice or candy, this aluminum scoop is poised to get the job done. Product Features: Capacity: 5 oz. Dimensions: 2 3/8" w x 5" l |
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River of Hope: My Journey with Kathy in Search of Healing from Lou Gehrig's Disease by David Tank (Author) This true story chronicles the frustrations and joys of Kathy Tank as she fought to beat Lou Gehrig's disease (ALS), which she refered to as this monster within me. Told from the perspective of her husband, River of Hope reveals how a regimen of pharmaceutically-based medical care failed Kathy nearly every step of the way and how she discovered a sense of hope through alternative approaches to treating her disease. Kathy's story of determination and hope, her fight to beat a disease that the experts told her was unbeatable, is both inspiring and tragic, hopeful and heartbreaking. Along her journey you will be introduced to some of the wonderful, caring people whom Kathy met when she stepped outside of established medicine. River of Hope is a rare and intimate look into a... |
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Informed EMS Field Guide ALS Version 16th Edition by InforMed EMS Field Guide ALSNewly revised 16th edition! This small flip-chart booklet makes it easy for Paramedics, Nurses and Physicians to look up their patients' medications, check drug doses, quickly interpret 12-Lead EKGs and much more!At only 3" x 5" it easily fits in your pocket, has color-coded tabs, and is Waterproof, Alcohol-fast and "Street-Tough."This New & Improved Guide has:* Airway Management, including the new King LT Airway* New Top 1800 Prescription Drugs* Laryngeal Mask Airway / RSI* Poisons & Overdose / "Rave" Drugs* Medical Emergencies Section* ACLS Algorithms* 82 Emergency & ACLS Drugs* 12-Lead ECG Section & Acute MI* IV Drips, Drug Infusions, Dosages* Fibrinolytics for AMI & Stroke / CVA* Childbirth, Diabetic, Respiratory Distress* Pediatric Resuscitation, Drug Doses,... |
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Pocket Reference for ALS Providers (3rd Edition) by Dwayne E. Clayden (Author), Bryan E. Bledsoe (Author) This handy pocket-sized reference has been completely revised to have the best information for Paramedics in a quickly accessible format. A convenient 4 x 6 size is ideal for responders on the go. Charts and tables throughout allow users to find information fast. Completely revised and updated with much NEW content, this book now includes chapters on Pediatric and Neonatal, Special Operations, Acute Coronary Syndrome, Pharmacology, and Documentation. |
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