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Researchers test old drug with new hopes for pre-eclampsia cure
September 17, 2007GALVESTON, Texas - Researchers at the University of Texas Medical Branch at Galveston are trying to determine whether a drug already available to heart patients can also be used to delay delivery in expectant mothers with severe preeclampsia. If so, this groundbreaking study would give hope to hundreds of thousands of women who experience this life-threatening disorder each year.
The drug, Digibind, has been prescribed for over 20 years to patients who overdose on a certain heart medication, but is not yet approved for preeclampsia, the most common and dangerous pregnancy complication affecting as many as eight in every 100 pregnant women. The disorder is characterized by high blood pressure, protein in the urine and multi-organ dysfunction, all of which can seriously harm both mother and fetus.
"Preeclampsia is the No. 1 killer of pregnant women in the world, and there is no cure except delivery," said Dr. George Saade, chief of maternal-fetal medicine at UTMB. "When it is severe and occurs early in the pregnancy, delivery in order to protect the mother results in a premature baby. That's why this study is important, because if the medication works, then we can protect the mom while allowing the baby to grow and develop without delivering early."
The clinical trial will test whether Digibind reverses or prevents the abnormalities that occur with preeclampsia and allows the fetus to remain in the womb longer. This would give doctors more time to administer steroids to prevent respiratory complications in premature births and reduce the need for costly and lengthy neonatal intensive care.
"Right now, there is no treatment for preeclampsia, so this is truly groundbreaking," said Dr. Nicole Ruddock, the study's principal investigator and an instructor in UTMB's Department of Obstetrics and Gynecology.
University of Texas Medical Branch at Galveston
The clinical trial will test whether Digibind reverses or prevents the abnormalities that occur with preeclampsia and allows the fetus to remain in the womb longer. This would give doctors more time to administer steroids to prevent respiratory complications in premature births and reduce the need for costly and lengthy neonatal intensive care.
"Right now, there is no treatment for preeclampsia, so this is truly groundbreaking," said Dr. Nicole Ruddock, the study's principal investigator and an instructor in UTMB's Department of Obstetrics and Gynecology.
University of Texas Medical Branch at Galveston
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Pregnancy complications are a stress test for future maternal health and pregnancies
Predicting whether pregnancy complications affect long-term maternal health as well as future pregnancies is at the heart of two studies conducted by researchers in the Department of Obstetrics, Gynecology and Reproductive Sciences at Yale School of Medicine.
Increasing age of mothers in Spain leads to rise in mortality rates
A new study examining the evolution of maternal mortality rates in Spain since 1996 shows a 17% increase in deaths. This trend is linked to the widespread increase in maternal age. The highest death rates are among foreign women and those who live in the province of Malaga.
Complications early in pregnancy or in previous pregnancies adversely affect existing or subsequent pregnancies
Complications in early pregnancy or in previous pregnancies can predict the likelihood of further problems in current or subsequent pregnancies, according to research carried out by an international group of experts.
Taking folic acid for a year before pregnancy may reduce risk of preterm birth
Women who take folic acid supplements for at least one year before they become pregnant may cut their risk of having a premature baby by half, according to research published this week in the online journal, PLoS Medicine.
Management of asthma during pregnancy can optimize health of mother and baby
Pregnant women with asthma, the most common condition affecting the lungs during pregnancy, should actively manage their asthma in order to optimize the health of mother and the baby, according to new management recommendations published in the current issue of the New England Journal of Medicine.
Reducing Health Risks for Women and Children: American Dietetic Association Releases Position Paper on Obesity, Reproduction and Pregnancy Outcomes
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The new 'epigenetics:' Poor nutrition in the womb causes permanent genetic changes in the offspring
The new science of epigenetics explains how genes can be modified by the environment, and a prime result of epigenetic inquiry has just been published online in The FASEB Journal: You are what your mother did not eat during pregnancy.
1 in 7 U.S. Teens Is Vitamin D Deficient
One in seven American adolescents is vitamin D deficient, according to a new study by researchers in the Department of Public Health at Weill Cornell Medical College. The findings are published in the March issue of the journal Pediatrics and were presented at the Pediatric Academic Societies' Annual Meeting in May 2008.
A reversal of thinking: How women with lupus can increase chance for healthy pregnancies
In the not so distant past, women with systemic lupus erythematosus (SLE), an autoimmune disease, were advised not to have children, and if they became pregnant, to have therapeutic abortions to prevent severe flares of their lupus.
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L Arginine 750 mg, 60 Capsules - Pharmaceutical Grade by Club Natural Arginine (also called L arginine) is a semi-essential amino acid involved in numerous areas of human biochemistry. Arginine is also well known as a precursor to nitric oxide (NO), a key component of endothelial-derived relaxing factor, a messenger molecule involved in a variety of endothelium-dependent physiological effects.* Take a look at a highly popular and effective sexual enhancement product, Passion Rx - click on your right below the Passion Rx bottle image. We have a high reorder rate for this product formulated by world renowned herbal expert and best selling author Ray Sahelian, M.D. Passion Rx does not have arginine. History of L Arginine :: L Arginine was first isolated in 1886. In 1932, L arginine was found to be required for the generation of urea, which is necessary for... |
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