Science Current Events | Science News | Brightsurf.com
 
Email a Friend Send to a friend
Printer Friendly Print Smart Insulin Nanostructures Pass Feasibility Test, UT Study Reports
Slashdot It! Slashdot Smart Insulin Nanostructures Pass Feasibility Test, UT Study Reports
Submit to Reddit Submit Smart Insulin Nanostructures Pass Feasibility Test, UT Study Reports to Reddit
Reading: Smart Insulin Nanostructures Pass Feasibility Test, UT Study ReportsTwitter This Reading: Smart Insulin Nanostructures Pass Feasibility Test, UT Study ReportsTwitter Smart Insulin Nanostructures Pass Feasibility Test, UT Study Reports
Add to Facebook Add Smart Insulin Nanostructures Pass Feasibility Test, UT Study Reports to Facebook

Smart Insulin Nanostructures Pass Feasibility Test, UT Study Reports

September 21, 2007

Biomedical engineers at The University of Texas School of Health Information Sciences at Houston have announced pre-clinical test results in the September issue of the International Journal of Nanomedicine demonstrating the feasibility of a smart particle insulin release system that detects spikes in glucose or blood sugar levels and releases insulin to counteract them.

Designed to mimic functions of the pancreas which produces the blood-sugar regulating hormone insulin, the smart particle system stabilized blood sugar levels in animal models with suppressed pancreatic functions for up to six hours, researchers reported. It is an inhalable system.




The study, "Glucose-sensing pulmonary delivery of human insulin to the systemic circulation of rats," was conducted in the laboratory of Ananth V. Annapragada, Ph.D., an associate professor at the UT School of Health Information Sciences. Research assistant Efstathios Karathanasis was lead author and postdoctoral fellow Rohan C. Bhavane was a contributor on the article.

The smart particle system consists of a blood sugar sensing protein named concanavalin A (Con A) and bundles of tiny fat bubbles called liposomes that are loaded with insulin. "Con A binds insulin-containing liposomes that are coated with sugars, to each other, to form the inhaled particles," Annapragada said. "When blood sugar becomes present, the Con A releases the particles to bind independently to the sugars. The released particles then release their insulin."

Hundreds of thousands of individuals suffer Type I diabetes, a condition that develops when the body's immune system destroys pancreatic beta cells - the only cells that make insulin. High blood sugar levels can lead to serious complications and premature death.

"No one had ever shown that an inhalable smart release system was viable," said Annapragada, who describes the study as a "proof of concept" initiative. He said additional work - including the discovery of less inflammatory blood sugar sensing proteins or small molecules - will be required before its efficacy for patients can be tested in clinical trials.

The smart particle system could potentially treat other health conditions, he said.

The article in the International Journal of Nanomedicine is available online at: http://www.dovepress.com/articles.php?content_id=1152 Smart particle research is supported by the Whitaker Foundation Bioengineering Research Grant and the Gillson-Longenbaugh Foundation.

The University of Texas School of Health Information Sciences at Houston





Science News and Science Current Events Tag Cloud
This tag cloud is a visual representation of term frequencies of random science news topics with common terms grouped together and emphasized by their display size.
Hiv Vaccine   Atomic Clock   Drug Resistance   Water Molecules   Antipsychotic   Tumor   Bipolar Disorder   Progesterone   Heart Muscle   Signaling Pathway   Rabies   Sexual Harassment   Secondhand Smoke   Neuroblastoma   DNA damage   Bison   Macrophages   Intestinal Bacteria   Taste   Bariatric Surgery   Clostridium difficile   Body Fat   Vitamin D Deficiency   Fruit Flies   Obese  
Related Insulin Current Events and Insulin News Articles Insulin Current Events and Insulin News RSS Insulin Current Events and Insulin News RSS
Genetically engineered mice yield clues to 'knocking out' cancer
Deleting two genes in mice responsible for repairing DNA strands damaged by oxidation leads to several types of tumors, providing additional evidence that such stress contributes to the development of cancer.

UT researcher: Interferon alpha can delay full onset of type I diabetes
A low dose of oral interferon alpha shows promise in preserving beta cell function for patients with newly diagnosed type 1 diabetes, or juvenile diabetes.

Polycystic ovarian syndrome: New light on its causes and its effect on brothers
Researchers have found evidence that chronic disease in either a mother or father can create unfavourable conditions in the womb that are associated with the development of polycystic ovarian syndrome (PCOS) in daughters.

Women with cystic fibrosis can have safe and successful fertility treatment
Women with cystic fibrosis can have fertility treatment to help them have babies without any long-term adverse effects on either themselves or their children.

Insulin analogue glargine possibly increases cancer risk
The risk of cancer possibly increases if patients with diabetes use the long-acting insulin analogue glargine instead of human insulin.

For Women With PCOS, Acupuncture And Exercise May Bring Relief, Reduce Risks
Exercise and electro-acupuncture treatments can reduce sympathetic nerve activity in women with polycystic ovarian syndrome (PCOS), according to a new study.

Glucose challenge test is accurate and economical for diabetes and prediabetes screening
A test commonly used to help identify women with diabetes during pregnancy may be an accurate, convenient and inexpensive way to screen the general population for unrecognized diabetes and prediabetes, according to Emory University researchers.

M. D. Anderson study finds strong relationship between high body mass index, pancreatic cancer
In reviewing the weight history of pancreatic cancer patients across their life spans, researchers at The University of Texas M. D. Anderson Cancer Center have determined that a high body mass index in early adulthood may play a significant role in an individual developing the disease at an earlier age.

Care Management Reduces Depression and Suicidal Thoughts in Older Primary Care Patients
Depression in older adults too often goes unrecognized and untreated, resulting in untold misery, worsening of medical illness, and early death. A new study has identified one important remedy: Adding a trained depression care manager to primary care practices can increase the number of patients receiving treatment, lead to a higher remission rate of depression, and reduce suicidal thoughts.

The battle for CRTC2: How obesity increases the risk for diabetes
Obesity is probably the most important factor in the development of insulin resistance, but science's understanding of the chain of events is still spotty.
More Insulin Current Events and Insulin News Articles
EasyTouch Insulin Syringe 28 Gauge, 1cc, 1/2

EasyTouch Insulin Syringe 28 Gauge, 1cc, 1/2", 100 Count
by Masters Healthcare

12.7mm needle. For 100 units or less. Film coated for maximum comfort. 100% latex free. Special surgical grade stainless steel..

The Insulin-Resistance Diet--Revised and Updated: How to Turn Off Your Body's Fat-Making Machine

The Insulin-Resistance Diet--Revised and Updated: How to Turn Off Your Body's Fat-Making Machine
by Cheryle Hart (Author), Mary Kay Grossman (Author)

Conquer insulin resistance. Reduce cravings. Eat your favorite foods. And lose weight!

If you have tried every diet and are still struggling with your weight, the real culprit may be insulin resistance. When you have more glucose than your body needs, your body responds by producing more insulin to stabilize your blood sugar level and store the excess glucose as fat. In The Insulin-Resistance Diet, Cheryle R. Hart and Mary Kay Grossman show you how to control insulin resistance and lose weight without sacrificing all of your favorite foods.

Overcome insulin resistance and lose weight with:

The exclusive Link-and-Balance Eating Method, which balances carbs with the right amount of protein at the right time for maximum weight loss Self-tests to...

Using Insulin, Everything You Need for Success With Insulin

Using Insulin, Everything You Need for Success With Insulin
by John Walsh (Author), Ruth Roberts (Author), Timothy Bailey (Author), Chandra B. Varma (Author)



Protector Insulin Case - Blue

Protector Insulin Case - Blue
by Medicool

Most doctors recommend insulin be kept refrigerated to ensure its maximum potency. When you use the Medicool Insulin Protector you can take a trip across country, knowing your insulin is cool and safe to use. The compact Protector is ideal for daily use and trips where a minimal amount of supplies are required.

The Discovery of Insulin: Twenty-fifth Anniversary Edition

The Discovery of Insulin: Twenty-fifth Anniversary Edition
by Michael Bliss (Author)

When insulin was discovered in the early 1920s, even jaded professionals marveled at how it brought starved, sometimes comatose diabetics back to life. In this now-classic study, Michael Bliss unearths a wealth of material, ranging from scientists’ unpublished memoirs to the confidential appraisals of insulin by members of the Nobel Committee. He also resolves a longstanding controversy dating to the awarding of the Nobel to F. G. Banting and J. J. R. Macleod for their work on insulin: because each insisted on sharing the credit with an additional associate, medical opinion was intensely divided over the allotment of credit for the discovery. Bliss also offers a wealth of new detail on such subjects as the treatment of diabetes before insulin and the...

1cc Insulin Syringe, 28 Gauge x 1/2

1cc Insulin Syringe, 28 Gauge x 1/2
by Nipro

The challenge of any manufacturer in today's demanding healthcare environment is to provide customers with products that deliver both exceptional performance and value. Monoject has lived up to that promise with a full range of injection systems that match a variety of clinical needs. Monoject's state-of-the-art manufacturing assures products of consistently high quality that also meet the most rigorous budget requirements. Disposable Syringes

The Glycemic Load Diet Cookbook:150 Recipes to Help You Lose Weight and Reverse Insulin Resistance

The Glycemic Load Diet Cookbook:150 Recipes to Help You Lose Weight and Reverse Insulin Resistance
by McGraw-Hill

150 scientifically designed, "low-load" recipes for your health-conscious lifestyle Taking his cutting-edge conceptsone step further, Dr. Rob Thompson, author of the bestselilng The Glycemic-Load Diet,  combines the breakthroughscience of the glycemic load with the culinary expertise of bestselling cookbook author Dana Carpender. The result: 150 mouthwatering recipes and quick low-load meals to help you lose weight, cut cravings, speed up metabolism, and manage insulin resistance.

Practical Insulin: A Handbook for Prescribing Providers, 2nd Edition (American Diabetes Association)

Practical Insulin: A Handbook for Prescribing Providers, 2nd Edition (American Diabetes Association)
by American Diabetes Association (Author)

Reliable information in a handy pocket reference

Practical Insulin is a revised version of a popular bestseller.Now, with information on the newly FDA-approved insulins, such as inhaled, this handy reference gives you fast, reliable information to overcome the challenges you face in choosing a regime to effectively manage insulin resistance. It includes data on all types of insulin, mixing insulins, absorption rates, and more.

U-40 Insulin Syringe 1/2cc (100 pack) Medium Dose 29 Gauge 1/2

U-40 Insulin Syringe 1/2cc (100 pack) Medium Dose 29 Gauge 1/2"
by Ulti Med, Inc.

Sterile insulin syringe with attached Ulti-Fine 29 gauge needle for use with U-40 insulin products. Recommended to use with Vetsulin insulin (U-40) and for 20 units or less insulin dosage. UltiCare U-40 syringes are designed to provide the proper dose of U-40 insulin. This means that measurements of one unit of the UltiCare U-40 syringe will give you precisely one unit of U-40 insulin. Using the UltiCare U-40 syringe means that you can fill the syringe in the normal manner and do not need to rely on any conversion tables.

Insulow Dietary Supplement, Capsules, 180-Count Bottle

Insulow Dietary Supplement, Capsules, 180-Count Bottle
by Insulow

Insulow, recommended in Diabetes Solutions by Dr. R. Bernstein, is pure R+ Lipoic acid complexed with essential Biotin. R+ lipoic enhances glucose uptake and insulin sensitivity which reduces insulin spike after carbohydrate containing meals. Improving carbohydrate uptake and utilization can increase energy levels and improve your ability to use both fat and carbohydrates for energy.

© 2009 BrightSurf.com