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A search for biomarkers for early detection of colorectal cancer
September 25, 2007Researchers at the Zhejiang University, Hangzhou have discovered that mimecan and Thioredoxin Domain-Containing Protein 5 (TXNDC5) were differentially expressed in colorectal adenoma. The research article describing this work entitled "Differential Expression of Mimecan and Thioredoxin Domain-Containing Protein 5 in Colorectal Adenoma and Cancer: A Proteomic Study" will be featured in the October 2007 issue of Experimental Biology and Medicine.
Adenoma is the major precursor lesion of colorectal cancer, one of the most common cancers worldwide. The elucidation of the molecular mechanism underlying adenoma is essential for early detection, prevention and intervention of colorectal cancer.
The research team, led by Maode Lai, a professor of molecular pathology, found 27 differentially expressed proteins in colorectal adenoma using two dimensional electrophoresis (2-DE) and mass spectrometry. Western-blot analysis clearly validated 2 differentially expressed proteins, mimecan downregulation and TXNDC5 upregulation in colorectal adenomas and cancers.
"Adenoma is a very important step in the development of cancer. Discovering the biomarker of adenoma will improve the early detection and prevention of cancer," said Lai. "2-DE is an efficient traditional approach for the identification of differentially expressed proteins in cancer biology. Using this technology, we first identified 27 differentially expressed proteins in individual-matched colorectal normal, adenoma and cancer tissues."
"This study found two novel proteins which have never been found to be associated with colorectal cancer. We clearly demonstrated that absence of mimecan and up-regulation of TXNDC5 were involved in the early development of colorectal cancer," said the article's first author Yinghong Wang. "Our further work showed that mimecan can inhibit cell growth and induce cell apoptosis in colorectal cancer cells implying a candidate role as a tumor suppressor gene for the mimecan gene. These results suggested that mimecan might serve as a potential biomarker for future gene therapy."
Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, said "Lai and his colleagues have performed a protein profiling proteomic study to understand the molecular mechanisms leading to colorectal cancer. It is this type of approach which can lead to the identification of biomarkers for the early detection of colorectal cancer, and targets for future gene therapy".
Society for Experimental Biology and Medicine
"Adenoma is a very important step in the development of cancer. Discovering the biomarker of adenoma will improve the early detection and prevention of cancer," said Lai. "2-DE is an efficient traditional approach for the identification of differentially expressed proteins in cancer biology. Using this technology, we first identified 27 differentially expressed proteins in individual-matched colorectal normal, adenoma and cancer tissues."
"This study found two novel proteins which have never been found to be associated with colorectal cancer. We clearly demonstrated that absence of mimecan and up-regulation of TXNDC5 were involved in the early development of colorectal cancer," said the article's first author Yinghong Wang. "Our further work showed that mimecan can inhibit cell growth and induce cell apoptosis in colorectal cancer cells implying a candidate role as a tumor suppressor gene for the mimecan gene. These results suggested that mimecan might serve as a potential biomarker for future gene therapy."
Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, said "Lai and his colleagues have performed a protein profiling proteomic study to understand the molecular mechanisms leading to colorectal cancer. It is this type of approach which can lead to the identification of biomarkers for the early detection of colorectal cancer, and targets for future gene therapy".
Society for Experimental Biology and Medicine
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Colorectal Cancer Current Events and Colorectal Cancer News RSSColorectal cancer
Previously, only a few genes had been associated with the formation of metastases in colorectal cancer. Now, researchers of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch and Charité - University Medicine Berlin, Germany, have identified 115 genes that are disregulated both in the primary tumor and in its metastases.
Study finds improved communication encourages patients to seek colorectal cancer screening
Improved communication among patients and primary care physicians increases the chances those due for colorectal cancer screening will follow their doctors' advice and complete the procedure, a University at Buffalo study has found.
Study finds people residing in poor communities not benefiting from recent drop in colorectal cancer
A new study suggests that a drop in colorectal cancer incidence seen nationwide has not occurred among people living in poorer communities, and suggests that barriers to health care may be to blame.
Advances in liver surgery enable the prospect of curative treatment for more patients
Although many prognostic factors predicting survival and cancer recurrence in patients undergoing surgery for colorectal liver metastases are already identified, the effects of newly introduced technologies and new drugs in the treatment of these patients are still poorly studied because of the presence of many involved factors.
What are the risk factors of sporadic colorectal cancer?
Colorectal cancer (CRC) is one of the most common cancers in China.
Gene therapy technique thwarts cancer by cutting off tumor blood supply
University of Florida researchers have come up with a new gene therapy method to disrupt cancer growth by using a synthetic protein to induce blood clotting that cuts off a tumor's blood and nutrient supply.
Study finds colorectal cancer rates increasing worldwide
A new study finds colorectal cancer incidence rates for both males and females increased in 27 of 51 countries worldwide between 1983 and 2002, and points to increasing Westernization as being a likely culprit.
Study says colorectal cancer increasing in young adults
A new study finds that in sharp contrast to the overall declining rates of colorectal cancer in the United States, incidence rates among adults younger than age 50 years are increasing.
Improved DNA stool test could detect digestive cancers in multiple organs
Mayo Clinic researchers have demonstrated that a noninvasive screening test can detect not only colorectal cancer but also the common cancers above the colon -- including pancreas, stomach, biliary and esophageal cancers.
Alcohol and smoking are key causes for bowel cancer
A new global study has found that lifestyle risk factors such as alcohol consumption and cigarette smoking are important risk factors for bowel cancer.
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