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C-diff infection 4 times more likely to kill patients with inflammatory bowel disease
September 27, 2007Excess hospitalization burden associated with Clostridium difficile in patients with inflammatory bowel disease
Clostridium difficile infection is four times more likely to kill patients with inflammatory bowel disease, suggests research published ahead of print in the journal Gut.
C difficile is an important cause of diarrhoea among inpatients, and the numbers of new cases of the infection have been steadily increasing in recent years.
The findings are based on a representative sample of community hospital admissions in the US for 2003.
The sample covered 994 hospitals in 37 States and included a total of 124,570 patients.
Of these, 44,400 had been admitted with C difficile infection, and 77,366 had been admitted with inflammatory bowel disease (Crohn's disease or ulcerative colitis), or IBD for short.
A further 2,804 had both IBD and C difficile infection.
Those with the infection alone tended to be considerably older, and had an average age of 73. Those with IBD had an average age of 42.
The risk of death was higher among those with C difficile infection alone or in combination with IBD than it was in those with IBD alone.
But patients with both the infection and IBD were four times more likely to die than patients with just IBD or C difficile infection alone, irrespective of age.
Patients with the combination also stayed in hospital three days longer and had higher rates of endoscopy, a procedure in which a long tube with a camera on the end is passed through the gut.
Patients with ulcerative colitis had more severe C difficile infection than those with Crohn's disease and worse outcomes.
The authors conclude that patients with IBD may be particularly susceptible to infection with C difficile.
BMJ Specialty Journals
The findings are based on a representative sample of community hospital admissions in the US for 2003.
The sample covered 994 hospitals in 37 States and included a total of 124,570 patients.
Of these, 44,400 had been admitted with C difficile infection, and 77,366 had been admitted with inflammatory bowel disease (Crohn's disease or ulcerative colitis), or IBD for short.
A further 2,804 had both IBD and C difficile infection.
Those with the infection alone tended to be considerably older, and had an average age of 73. Those with IBD had an average age of 42.
The risk of death was higher among those with C difficile infection alone or in combination with IBD than it was in those with IBD alone.
But patients with both the infection and IBD were four times more likely to die than patients with just IBD or C difficile infection alone, irrespective of age.
Patients with the combination also stayed in hospital three days longer and had higher rates of endoscopy, a procedure in which a long tube with a camera on the end is passed through the gut.
Patients with ulcerative colitis had more severe C difficile infection than those with Crohn's disease and worse outcomes.
The authors conclude that patients with IBD may be particularly susceptible to infection with C difficile.
BMJ Specialty Journals
Inflammatory Bowel Disease Current Events and Inflammatory Bowel Disease News RSSLargest gene study of childhood IBD identifies 5 new genes
In the largest, most comprehensive genetic analysis of childhood-onset inflammatory bowel disease (IBD), an international research team has identified five new gene regions, including one involved in a biological pathway that helps drive the painful inflammation of the digestive tract that characterizes the disease.
Gastroenterology/hepatology societies release report evaluating fellowship training curriculum
Due to the increasing complexities of treating digestive diseases, allowing gastroenterological (GI) trainee physicians the opportunity to develop enhanced abilities and experiences in specific disease areas or procedures will be a great benefit to patients, according to a "Report of the Multisociety Task Force on GI Training."
M. D. Anderson redefines screening guidelines for breast, cervical and colorectal cancers
Drawing on years of experience in cancer research and patient care, The University of Texas M. D. Anderson Cancer Center released today the most comprehensive, risk-based screening guidelines publicly available to date for breast, cervical and colorectal cancers.
Probiotic Found to Be Effective Treatment for Colitis In Mice
The probiotic, Bacillus polyfermenticus, can help mice recover from colitis, a new study has found.
The bowels of infection
Current research suggests that latent cytomegalovirus (CMV) infection may exacerbate inflammatory bowel disease (IBD). The related report by Onyeagocha et al, "Latent cytomegalovirus infection exacerbates experimental colitis," appears in the November 2009 issue of The American Journal of Pathology.
Discovery of genetic defect may lead to better treatments for common gut diseases
New findings related to an uncommon genetic disorder may impact the diagnosis and treatment of inflammatory bowel disease (IBD), the most common chronic gastrointestinal illness in children and teens. Two million Americans have IBD which involves inflammation of the gastrointestinal tract.
Pitt researchers net $5 million from NIH to explore better ways to grow cells for regenerative medicine
Regenerative medicine researchers at the University of Pittsburgh received two grants totaling more than $5 million from the National Institutes of Health (NIH) to explore new methods for cultivating replacement cells from existing tissues and organs.
Visionary concept earns La Jolla Institute scientist prestigious NIH Pioneer Award
A scientist at the La Jolla Institute for Allergy & Immunology has received one of the National Institutes of Health (NIH)'s top awards -- the 2009 NIH Director's Pioneer Award.
Promising new target emerges for autoimmune diseases
University of Michigan scientists say they have uncovered a fundamentally new mechanism that holds in check aggressive immune cells that can attack the body's own cells.
Antimicrobial antibodies in celiac disease: Trick or treat?
Anti-microbial antibody formation has been reported in celiac disease.
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