 |
|
London School of Hygiene to play key role in global collaboration on adverse drug reactions
September 27, 2007The London School of Hygiene & Tropical Medicine is to be a key player in the first global research collaboration aimed at identifying the genetic markers related to Adverse Drug Reactions (ADRs).
The Serious Adverse Event Consortium (SAEC) is a non-profit global partnership between leading pharmaceutical companies, drug regulatory authorities and academic institutions aimed at identifying genetic markers that may help to predict which patients are at risk from adverse or serious drug reactions (ADRs). It will provide a global knowledge base about these genetic variations and will be a major step forward in the drive to develop and deliver safer medicines.
ADRs are important causes of illness, limit the usefulness of many otherwise effective drugs, and are under strong genetic influence. Identifying the genetic variants that may influence a patient's susceptibility to ADRs will greatly improve our understanding of the risk and molecular basis of adverse drug reactions.
Dr. Mariam Molokhia, Clinical Lecturer at the London School of Hygiene & Tropical Medicine, will be one of the main UK investigators of the collaborative project, and will be working jointly with SAEC to address clinical and scientific issues and identify DNA-variants useful in predicting the risk of drug-related serious adverse events, including liver toxicity and other series ADRs.
Dr. Molokhia co-ordinates the EUDRAGENE project, a European collaboration to establish a case-control DNA collection for studying the genetic basis of adverse drug reactions. She comments: 'Research in this area is hampered by a lack of resources. As most such ADRs are rare, a case-control design is the only feasible approach, and a multi-centre international collaboration is necessary as no single country will generate enough cases of any given ADR within a reasonable time. I am delighted that the London School of Hygiene & Tropical Medicine is going to be playing a key role in a project that will greatly improve our understanding of genetic variation in relation to drug safety'.
London School of Hygiene & Tropical Medicine
Dr. Mariam Molokhia, Clinical Lecturer at the London School of Hygiene & Tropical Medicine, will be one of the main UK investigators of the collaborative project, and will be working jointly with SAEC to address clinical and scientific issues and identify DNA-variants useful in predicting the risk of drug-related serious adverse events, including liver toxicity and other series ADRs.
Dr. Molokhia co-ordinates the EUDRAGENE project, a European collaboration to establish a case-control DNA collection for studying the genetic basis of adverse drug reactions. She comments: 'Research in this area is hampered by a lack of resources. As most such ADRs are rare, a case-control design is the only feasible approach, and a multi-centre international collaboration is necessary as no single country will generate enough cases of any given ADR within a reasonable time. I am delighted that the London School of Hygiene & Tropical Medicine is going to be playing a key role in a project that will greatly improve our understanding of genetic variation in relation to drug safety'.
London School of Hygiene & Tropical Medicine
New study shows epidural during birth may negatively affect breastfeeding
Epidurals given during labour and birth are associated with decreased rates of breastfeeding, both in the short and long term.
Survey highlights 'crucial' safety issues in rhinitis treatment, particularly in children
Children may be at risk of receiving rhinitis treatment that suppresses growth - but the problem can be avoided through careful selection of treatment. This was the overwhelming message emerging from a recent nationwide survey of ENT specialists. According to the findings, the vast majority (91%) of specialists surveyed said they considered growth suppression the most important potential adverse drug reaction associated with nasal steroids. And a similar proportion (88%) said the selection of a nasal steroid for a child should be based on its low potential for adverse effects on growth. The use of systemic steroids has been linked to growth suppression but the danger is not necessarily avoid
More Adverse Drug Reaction Current Events and Adverse Drug Reaction News Articles
 |
Stephens' Detection of New Adverse Drug Reactions by John Talbot (Editor), Patrick Waller (Editor) A key text for all those involved in pharmacovigilance. Detection of new adverse drug reactions is fundamental to the protection of patients from harm that may occur as a result of medication. This book explores the methods used to investigate new adverse drug reactions, discussing all elements from the scientific background and animal toxicology through to worldwide regulatory and ethical issues. Stephens' Detection of New Adverse Drug Reactions provides comprehensive and up-to-date coverage of material fundamentally important to all those active in the field, whether they work in the pharmaceutical industry, drug regulatory authorities or in academia. The fifth edition of this classic reference work includes new chapters on: vaccine safety... |
 |
Side Effects of Drugs Annual 26, Volume 26: A world-wide yearly survey of new data and trends in adverse drug reactions by Author Unknown (Author) The Side Effects of Drugs Annual was first published in 1977. It has been published continuously since then, as a yearly update to the encyclopaedic volume Meyler's Side Effects of Drugs. Each new Annual provides clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of Adverse Drug Reactions and Interactions.
|
 |
Side Effects of Drugs Annual 30, Volume 30: A worldwide yearly survey of new data and trends in adverse drug reactions by Jeffrey K. Aronson MA DPhil MBChB FRCP FBPharmacolS FFPM(Hon) (Editor) The Side Effects of Drugs Annual was first published in 1977. It has been continually published since then, as a yearly update to the voluminous encyclopedia Meyler's Side Effects of Drugs. Each new Annual continues to provide clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of Adverse Drug Reactions and Interactions. An international team of specialists has contributed to the informative, by critically interpreting it, and by pointing to whatever is misleading. Provides a critical yearly survey of new data and trends in the side effects of drugs. Each drug article contains case histories. Contains detailed information on drug-drug interactions. |
 |
Adverse Drug Reactions by Anne Lee (Editor) Adverse reactions to medicines continue to present a considerable burden on healthcare, causing considerable morbidity and mortality. As well as knowing about the benefits of medicines, healthcare professionals need to understand the problem of adverse drug reactions and be aware of how they can be prevented and managed. The new edition of this essential and practical guide has been extensively revised and updated. |
 |
Meyler's Side Effects of Drugs, Fifteenth Edition:The International Encyclopedia of Adverse Drug Reactions and Interactions 6 Volume Set(Meyler's Side Effects of Drugs) by Jeffrey K. Aronson MA DPhil MBChB FRCP FBPharmacolS FFPM(Hon) (Editor) Building on the success of the 14 previous editions, this remarkable reference has been extensively reorganized and expanded and now comprises almost 1,500 individual drug articles providing the most complete coverage of adverse reactions and interactions found anywhere. Each article contains detailed and authoritative information about the adverse effects of each drug, with comprehensive references to the primary literature making this a must have for any academic or medical library, pharmacologist, regulatory organization, hospital dispensary or pharmaceutical company. Now available online for all academic, corporate or government institution as well as individuals via Science Direct! The online version provides an unparalleled depth of coverage and functionality by offering... |
 |
Adverse Drug Reactions: A Practical Guide to Diagnosis and Management by Christian Bénichou (Editor) This text will be of enormous value to anyone involved in the monitoring and investigation of adverse medical events occurring during the clinical trials, or during the post marketing period of a drug. The book reviews the biochemical and physiological abnormalities in each of the bodys organ systems and helps the investigator decide if the problem is of drug-induced origin. Most of the information is presented as a series of observations with accompanying questions which should be addressed in order to make an accurate diagnosis. Easy-to-read with useful flow charts for the management of adverse drug events and examples of specific report forms, this text will be of interest to all those involved in drug monitoring in clinical medicine, pharmaceutical companies, contract research... |
 |
Side Effects of Drugs Annual 29, Volume 29: A worldwide yearly survey of new data and trends in adverse drug reactions by Jeffrey K. Aronson MA DPhil MBChB FRCP FBPharmacolS FFPM(Hon) (Editor) The Side Effects of Drugs Annual was first published in 1977. It has been continually published since then, as a yearly update to the voluminous encyclopedia Meyler's Side Effects of Drugs. Each new Annual continues to provide clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of Adverse Drug Reactions and Interactions. An international team of specialists has contributed to the Annuals by selecting critically from each year's writing all that is truly new and informative, by critically interpreting it, and by pointing to whatever is misleading. *Provides a critical yearly survey of new data and trends *Includes an essay that describes the modern approach to classifying... |
|
Textbook of Adverse Drug Reactions (Oxford Medical Publications) by D. M. Davies (Editor) Following the publication of its first edition, this book quickly established itself as an important, encyclopedic work. It provides a map to guide clinicians through the jungle of toxicological fact and theory presented by the mass of reports on adverse reactions to drugs published in a multitude of medical books and journals. Taking a unique approach to the subject, this completely updated guide classifies adverse reactions by bodily systems and the drugs that may affect them, rather than by drugs and the disorders they may cause. This reflects the way in which drug-induced disease presents to the clinician in general or hospital practice, and means that the relevant information can be found quickly and easily. The Fourth Edition has been expanded and largely rewritten, with new authors... | |
 |
Side Effects of Drugs Annual 25, Volume 25: A world-wide survey of new data and trends in adverse drug reactions by Jeffrey K. Aronson MA DPhil MBChB FRCP FBPharmacolS FFPM(Hon) (Series Editor) Volume 25 in the series http://www.elsevier.com/locate/series/sedaSide Effects of Drugs Annuals continues to serve the goal that is set for it: to provide clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of Adverse Drug Reactions and Interactions. An international team of specialists has reviewed new data and trends by selecting from the year's writing all that is truly new and informative, by critically interpreting it, and by pointing to whatever is misleading.
|
|
Many serious adverse drug reactions noted after approval. (FDA Standards Questioned).: An article from: Skin & Allergy News by Diana Mahoney (Author) This digital document is an article from Skin & Allergy News, published by International Medical News Group on June 1, 2002. The length of the article is 490 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Many serious adverse drug reactions noted after approval. (FDA Standards Questioned). Author: Diana Mahoney Publication: Skin & Allergy News (Magazine/Journal) Date: June 1, 2002 Publisher: International Medical News Group Volume: 33 Issue: 6 Page: 28(1) Distributed by Thomson... |
| © 2009 BrightSurf.com |