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Umbilical cord gene expression signals premature babies' lung disease risk
October 04, 2007Diagnosing a risk of fatal lung disorders may be possible by analysing the umbilical cords of premature babies, according to research published in the online open access journal Genome Biology. Until now, paediatricians have not been able to predict the development of bronchopulmonary dysplasia (BPD) because of the difficulties with obtaining lung samples.
Isaac Kohane and his team at the Children's Hospital, Boston, US, collected umbilical cord tissue samples from 54 premature infants born at less than 28 weeks of gestation, including 20 samples from infants who later developed BPD. When DNA expression profiles were compared, the researchers found that infants who subsequently developed BPD had distinct gene expression signatures that differed from the ones who did not develop the disease, although the maternal characteristics (for example, the cause of delivery, race, or inflammation of the uterus) were similar. The genes that differed between the two groups involved chromatin remodelling and histone acetylation pathways.
"This has provided a rare opportunity to examine the influence of foetal physiology on postnatal health and development using the multiple tissues in umbilical cords as a proxy for a wide variety of tissues in the maternal-foetal unit," says Kohane.
BPD occurs in 20-40% of infants born below 1000 grams and before 28 weeks of gestation, and means babies still need supplemental oxygen at 36 weeks postmenstrual age. It is the second leading cause of death among infants born within this gestational age and is characterised by inflammation and scarring in the lungs.
The study by Kohane and colleagues will contribute towards generating prognostic markers for disease from umbilical cord profiles.
BioMed Central
BPD occurs in 20-40% of infants born below 1000 grams and before 28 weeks of gestation, and means babies still need supplemental oxygen at 36 weeks postmenstrual age. It is the second leading cause of death among infants born within this gestational age and is characterised by inflammation and scarring in the lungs.
The study by Kohane and colleagues will contribute towards generating prognostic markers for disease from umbilical cord profiles.
BioMed Central
Umbilical Cord Current Events and Umbilical Cord News RSSUmbilical cord blood stem cell transplant may help lung, heart disorders
Two separate studies published in the current issue of Cell Transplantation (18:8), - now freely available on-line have shown that transplanted human-derived umbilical cord blood (UCB) stem cells transplanted in an animal model had positive therapeutic effects on specific lung and heart disorders the animal models.
U of M researchers find 2 units of umbilical cord blood reduce risk of leukemia recurrence
A new study from the Masonic Cancer Center, University of Minnesota shows that patients who have acute leukemia and are transplanted with two units of umbilical cord blood (UCB) have significantly reduced risk of the disease returning.
The use of stem cells in regenerative medicine may also be detrimental for health
The use of stem cells in regenerative medicine is not always beneficial for human health, it may even be harmful according to a work done by the University of Granada and University of León. Scientists have demonstrated that transplantation of human mononuclear cells isolated from umbilical cord blood exerted a deleterious effect in rats with liver cirrhosis.
NIH launches 2009 H1N1 influenza vaccine trials in HIV-infected pregnant women
The first clinical trials to test whether the 2009 H1N1 influenza vaccine can safely elicit a protective immune response in pregnant women launched yesterday, and a trial to conduct the same test in HIV-infected children and youth will begin next week.
Major improvements made in engineering heart repair patches from stem cells
University of Washington (UW) researchers have succeeded in engineering human tissue patches free of some problems that have stymied stem-cell repair for damaged hearts.
Private umbilical cord banking not cost-effective, UCSF research shows
Private cord blood banking is not cost-effective because it costs an additional $1,374,246 per life-year gained, according to a new analysis by UCSF researchers.
Stem cell research: From molecular physiology to therapeutic applications
Stem cell research promises remedies to many devastating diseases that are currently incurable, ranging from diabetes and Parkinson's disease to paralysis.
Experimental treatment halts hypoxic-ischemic brain injury in newborns
Inhibiting an enzyme in the brains of newborns suffering from oxygen and blood flow deprivation stops a type of brain damage that is a leading cause of cerebral palsy, mental retardation and death, according to researchers at Cincinnati Children's Hospital Medical Center.
Children's Hospital Oakland scientists first to discover new source for harvesting stem cells
A groundbreaking study conducted by Children's Hospital & Research Center Oakland is the first to reveal a new avenue for harvesting stem cells from a woman's placenta, or more specifically the discarded placentas of healthy newborns.
MIT: New system monitors fetal heartbeat
Tiny fluctuations in a fetus's heartbeat can indicate distress, but currently there is no way to detect such subtle variations except during labor, when it could be too late to prevent serious or even fatal complications.
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Umbilical Cord Stem Cell Therapy: The Gift of Healing from Healthy Newborns by Anthony G. Payne (Author), David Steenblock (Author) We are standing at the threshold of a new and exciting medical era-an era of regeneration, rejuvenation, and renewal in which stems cells will set the stage for healing and in some cases, the restoration of injured, diseased, and debilitated tissues and organ. While stem cell therapy is still in its infancy, the field is rich with promise. The debate over the use of embryonic stem cells and the questionable effectiveness of adult stem cells have led many scientists and clinicians to concentrate their energies on umbilical-cord-derived stem cells from healthy newborn babies. While these cells are technically classifed as "adult stem cells," they appear to have greater restorative and regenerative potential than stem cells derived from adult tissues due to their young age. Human... |
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ABC News Nightline Your Child's Umbilical Cord If you could derive medical benefits by harvesting the blood from a freshly discarded umbilical cord, it's hard to think of any ethical reason why you shouldn't do so. As it is, about 3.5 million umbilical chords are thrown into the trash every year. Since that cord blood, as it's known, is rich in blood-forming stem cells, which can then be used in transplantation instead of bone marrow, saving it, storing it would seem to make eminently good sense. Indeed, there are already several thriving businesses that have grown up around that very premise. For a couple of thousand dollars or so, the companies will collect the blood from your baby's umbilical cord. And for about $100 a year, they'll store it in a refrigerated container. Then, should the baby or any immediate member of the... |
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I'm Surprised He Hasn't Killed Anyone by Massacre of the Umbilical Cord Imagine living in a town that basically exists to serve the leisure-time needs of an increasingly bloated and ignorant populace that rolls in every summer like an unclaimed uncle. In the warm months, you wait on hand and foot for people who define vacation by what kind of sticker they can put on the SUV back home. In the cold months, you vow to yourself "never again." Welcome to Myrtle Beach, South Carolina, home to MASSACRE OF THE UMBILICAL CORD. Featuring an astonishingly adept trio of musicians, MASSACRE OF THE UMBILICAL CORD viciously and unapologetically espouses and delivers the good tidings of "Eat Shit And Die." Requiring the services of only one drummer, a guitarist, and a vocalist, MOTUC is the sound of a tourist trap being held captive and peppered with precise blasts... |
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I'm Surprised He Hasn't Killed Anyone Massacre Of The Umbilical Cord (Primary Contributor) |
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Reborn Baby Girl with Umbilical Cord and she is Anatomically Correct! by Berenguer | |
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