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Medimmune announces phase 2 safety data for anti-RSV antibody and national RSV surveillance results
October 05, 2007MedImmune, Inc. today announced results from two important studies presented at the 2007 Infectious Diseases Society of America (IDSA) 45th Annual Meeting adding to the body of knowledge about respiratory syncytial virus (RSV). RSV is a viral pathogen that produces annual outbreaks usually between fall and spring. While RSV typically manifests cold-like symptoms in healthy children, it can prove to be a very serious respiratory illness for premature infants and is the leading cause of respiratory infections for newborns each year. MedImmune has long been committed to developing and improving products for prevention of RSV disease and to enhancing the body of knowledge about RSV epidemiology.
"MedImmune continues to forge ahead with its aggressive strategy to help combat RSV disease," said Edward M. Connor, M.D., executive vice president and chief medical officer. "We are pleased to present new Phase 2 data at IDSA regarding motavizumab, a key investigational monoclonal antibody (MAb) within our product development portfolio that we are currently preparing for regulatory submission in the United States."
Connor added, "We will also present data regarding RSV surveillance at IDSA. These data show regional variability of RSV in the community, particularly in the southernmost United States. We believe that a better understanding of the regional variation in the timing of RSV may help inform decisions about timing of RSV prophylaxis for children at risk for serious RSV disease."
Data pertaining to MedImmune's anti-RSV initiatives that will be presented during the IDSA meeting include:
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Safety, Tolerability, and Immunogenicity of Motavizumab in Young Children After a Second Season of RSV Prophylaxis (Poster Presentation #233) - Katia G. Abarca, M.D., Infectious Diseases and Molecular Virology Laboratory, Universidad Católica de Chile, Friday, October 5, 2007; 12:30 - 2:00 p.m. in Poster Halls G-H.
This study assessed the safety and immunogenicity of motavizumab, an investigational anti-RSV MAb, in young children with a history of prematurity who received two sequential seasons of the antibody.
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RSV Surveillance: Retrospective and Current Data on the Variance in Season Onsets and Offsets (Poster Presentation #719) - Jessie R. Groothuis M.D., MedImmune, Saturday, October 6, 2007; 12:15 - 1:45 p.m. in Poster Halls G-H.
A nationwide active surveillance program was established to evaluate the variability of the RSV season temporally and geographically in the United States. Laboratory results from a three-year period were analyzed by month and by geographic region.
Edelman Public Relations
Data pertaining to MedImmune's anti-RSV initiatives that will be presented during the IDSA meeting include:
*
Safety, Tolerability, and Immunogenicity of Motavizumab in Young Children After a Second Season of RSV Prophylaxis (Poster Presentation #233) - Katia G. Abarca, M.D., Infectious Diseases and Molecular Virology Laboratory, Universidad Católica de Chile, Friday, October 5, 2007; 12:30 - 2:00 p.m. in Poster Halls G-H.
This study assessed the safety and immunogenicity of motavizumab, an investigational anti-RSV MAb, in young children with a history of prematurity who received two sequential seasons of the antibody.
*
RSV Surveillance: Retrospective and Current Data on the Variance in Season Onsets and Offsets (Poster Presentation #719) - Jessie R. Groothuis M.D., MedImmune, Saturday, October 6, 2007; 12:15 - 1:45 p.m. in Poster Halls G-H.
A nationwide active surveillance program was established to evaluate the variability of the RSV season temporally and geographically in the United States. Laboratory results from a three-year period were analyzed by month and by geographic region.
Edelman Public Relations
Infectious Disease Current Events and Infectious Disease News RSSPreventing H1N1 spread to health care workers: Dilemma, debate and confusion
A commentary in the December issue of The Lancet Infectious Diseases brings to light the gaps in knowledge on the transmission of a common pathogen - the influenza virus - and its impact on decisions about how best to protect health care workers.
Research calls for better assessment of tests for tuberculosis, HIV/AIDS and malaria
A rapid and accurate diagnosis is the first step towards treatment in the fight against infectious disease.
Researchers mobilizing global resources to test new treatments for severe H1N1 infection
An important, ground-breaking initiative is unfolding in the global critical care community in response to the H1N1 pandemic.
DNA barcodes: Creative new uses span health, fraud, smuggling, history, more
The scientific ability to quickly and accurately identify species through DNA "barcoding" is being embraced and applied by a growing legion of global authorities - from medical and agricultural researchers to police and customs authorities to palaeontologists and others.
Study reveals a 'missing link' in immune response to disease
The immune system's T cells have the unique responsibilities of being both jury and executioner. They examine other cells for signs of disease, including cancers or infections, and, if such evidence is found, rid them from the body. Precisely how T cells shift so swiftly from one role to another, however, has been a mystery.
Lessons from flu seasons past
Pregnant women who catch the flu are at serious risk for flu-related complications, including death, and that risk far outweighs the risk of possible side effects from injectable vaccines containing killed virus, according to an extensive review of published research and data from previous flu seasons.
Will genomics help prevent the next pandemic?
This week, the Public Library of Science, an open-access publisher, presents the "Genomics of Emerging Infectious Disease," a collection of essays, perspectives, and reviews that explores how genomics-with all its associated tools and techniques-can provide insights into our understanding of emerging infectious disease.
Important new novel 2009 H1N1 flu advisory for cardiopulmonary transplantation
Each year 3-5 million people have severe cases and 250-500,000 die from complications of seasonal influenza world-wide. This year, the novel 2009 H1N1 (nH1N1) influenza, previously called swine flu, has reached pandemic status.
MedImmune to present data on RSV and influenza at 2009 AAP National Conference and Exhibition
MedImmune announced today it will present four abstracts at the American Academy of Pediatrics (AAP) 2009 National Conference & Exhibition that add to the company's growing body of research on the burden of respiratory syncytial virus (RSV) on children, as well as pediatric infectious disease prevention.
Paradigm shift needed to combat drug resistance
When people travel, bacteria and other infectious agents travel with them. As about a billion people cross international borders each year, many more billions of the bugs come along for the ride.
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Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases: Expert Consult Premium Edition - Enhanced Online Features and Print by Gerald L. Mandell (Author) After thirty years, PPID is still the reference of choice for comprehensive, global guidance on diagnosing and treating the most challenging infectious diseases. Drs. Mandell, Bennett, and Dolin have substantially revised and meticulously updated, this new edition to save you time and to ensure you have the latest clinical and scientific knowledge at your fingertips. With new chapters, expanded and updated coverage, increased worldwide perspectives, and many new contributors, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 7th Edition helps you identify and treat whatever infectious disease you see. And, as an Expert Consult title with enhanced online features, this updated 7th edition comes with convenient access to the full text online, regular... |
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Infectious Diseases: A Clinical Short Course, Second Edition (LANGE Clinical Medicine) by Frederick Southwick (Author) Gain a full understanding of clinical infectious diseases in just thirty days A Doody's Core Title! No other resource makes clinical infectious diseases more manageable and easy to master than Infectious Diseases: A Clinical Short Course. This one-of-a-kind self-instruction tool is organized by system/region as opposed to pathogens -- simulating how common pathogens and disorders would be encountered in rounds or in practice. For this reason, this remarkable resource is unsurpassed for learning how to associate pathogens with their corresponding impact on actual patients. Features: A true, concise “short course” format that can be read and understood in the span of a 30-day infectious disease rotation Numerous case examples... |
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Clinical Infectious Disease by David Schlossberg (Editor) This clinically-oriented, user-friendly text is the best on the market for infectious disease. Complete and comprehensive, Schlossberg's text will be an effective reference for any practitioner who may encounter these afflictions. The orientation of the volume is multi-faceted: in addition to the traditional organization of organ system and pathogen-related information, this text includes specific sections on the susceptible host, travel-related infections, nosocomial infections, infections related to trauma, and bioterrorism. The information on post-surgical infections will be of great interest to practicing surgeons. Informative algorithms, tables, and high-quality color photographs supplement many of the chapters in this conveniently-sized volume. For practicality and ease of use, one... |
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Infectious Disease: A Scientific American Reader (Scientific American Readers) by Scientific American (Editor) The international public health scare that resulted last year when a man infected with multidrug-resistant tuberculosis flew overseas from the United States and back illustrates both the fear and the potential impact of highly infectious diseases in a global age. At a time when scientists warn of the potential for an influenza epidemic to rival the deadly outbreak of 1919 and newspapers feature alarming headlines about incidences of mad cow disease, infectious disease will be a critical area of concern and scientific study in the twenty-first century. Infectious Disease collects thirty of the most exciting, innovative, and significant articles on communicable illness published in the pages of Scientific American magazine since 1993. With sections devoted to viral infections,... |
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Infectious Diseases, Second Edition (EXPERT GUIDE SERIES- AMERICAN COLLEGE OF PHYSICIANS) by James S. Tan (Editor), Michael J. Tan (Editor), Robert A. Salata (Editor), Thomas M. File Jr. (Editor) Here s the expert guidance practitioners need to diagnose and treat the most commonly encountered infections! This fully revised and updated New Edition keeps readers current with the latest etiologic agents, the most appropriate diagnostic tests, and the most effective management options. The 2nd Edition features new chapters on Antimicrobial Agents for the Primary Care Physician and Prosthetic Joint Infections. FEATURES: -Examines infections of the central nervous system, heart and blood vessels, gastrointestinal tract, genitourinary system, respiratory tract, skeletal system, and the skin. -Features individual chapters on HIV, herpes virus, Lyme disease, and malaria. -Puts key information at the reader s fingertips with diagnostic and treatment tables throughout the text. -Reviews... |
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Case Studies in Infectious Disease by Peter Lydyard (Author), Michael Cole (Author), John Holton (Author), Will Irving (Author), Nino Porakishvili (Author), Pradhib Venkatesan (Author), Kate Ward (Author) Case Studies in Infectious Disease presents forty case studies featuring the most important human infectious diseases worldwide. Written for students of microbiology and medicine this book describes the natural history of infection from point of entry of the pathogen through pathogenesis, followed by clinical presentation, diagnosis and treatment. Five core sets of questions are posed in each case. What is the nature of the infectious agent, how does it gain access to the body, what cells are infected, and how does the organism spread? What are the host defense mechanisms against the agent and how is the disease caused? What are the typical manifestations of the infection and the complications that can occur? How is the infection diagnosed and what is the... |
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Oxford Handbook of Infectious Diseases and Microbiology (Oxford Handbooks Series) by Estee Torok (Author), Ed Moran (Author), Fiona Cooke (Author) Reflecting the current approach to koint postgraduate training programs in infectious diseases (ID) and microbiology, the Oxford Handbook of Infectious Diseases and Microbiology takes an integrated approach to both subjects. It covers the basic principles of bacteriology and virology, along with specific guidance on individual diseases and conditions, all in the accessible Oxford Handbook style. Practical and comprehensive, this handbook includes coverage of National Frameworks and current legislation, together with information on topical issues such as bioterrorism and preventative medicine. Fully reviewed by specialist senior readers and with useful links to up-to-date clinical information and online resources, this is an important addition to the Oxford Handbook series. |
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Current Diagnosis & Treatment In Infectious Diseases (Current Diagnosis and Treatment in Infectious Diseases) by Walter R. Wilson (Author) Numerous quick-access boxes and tables summarize key information on one of the leading causes of death. This title covers the essentials of diagnosis, syndromes in children and adults, and treatments, including first and second-choice options. It blends practice-oriented, authoritative coverage with just the right amount of microbiology for understanding diagnostic and management decisions. |
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Infectious Disease Epidemiology: Theory And Practice by Kenrad E., M.D. Nelson (Author), Carolyn F. Masters, Ph.D. Williams (Author) This thorough revision contains new chapters on principles of immunology, measles and polio, meningococcal infections, including pneumococcal, and influenza infections. The chapter on emerging infections has been divided into one of mosquito borne infections and includes West Nile Virus, Rift V and Dengue as well as other arthropod borne infections. SARS and Monkey Poxare included in the new chapter. All other chapters have been updated. |
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The A to Z of Infectious Diseases (Concise Encyclopedia) by Carol Turkington (Author), Bonnie Lee, M.d. Ashby (Author) In the past 25 years, more than 30 new germs affecting humans have emerged onto the medical scene, most of them rising from animals. New diseases like the avian flu, Ebola, SARS, and weaponized viruses such as anthrax and smallpox pose a growing danger to the world. With the threat of infectious diseases remaining constant, it is essential to have clear and concise information on this topic. "The A to Z of Infectious Diseases" provides more than 600 up-to-date entries covering the latest research, new treatments and vaccines, and rising diseases such as mad cow disease. Appendixes include drugs used to treat infectious diseases, tips for home disinfection, and lists of helpful organizations and publications, making this the ultimate resource for knowledge about infectious diseases. Topics... |
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