Double cardiovascular benefit for people with chronic kidney diseaseOctober 05, 2007New research, published today in the Journal of American Society of Nephrology by The George Institute for International Health in Sydney, has found that lowering blood pressure protects stroke victims with Chronic Kidney Disease from further strokes or heart attacks. Given the high risk of cardiovascular complications in people with Chronic Kidney Disease (CKD), these results have significant implications for millions of people across the world. According to lead author, Dr Vlado Perkovic at The George Institute, most of the CKD population will die from cardiovascular complications. "People with Chronic Kidney Disease are at a significantly greater risk of cardiovascular events than those without the disease. We found that approximately twice as many cardiovascular events were prevented when a perindopril based blood pressure lowering regimen was used in these people, compared to people with normal kidney function." The findings are based on a unique data set of around 1,800 patients who were part of a large clinical trial conducted on blood pressure and stroke, called PROGRESS. Dr Perkovic added that "The findings from PROGRESS have shifted the focus away from treating individuals with high blood pressure to focusing on those people at particularly high risk of heart disease and stroke. This research suggests that kidney function is an important parameter to consider in identifying these high risk individuals." Chronic Kidney Disease (CKD) affects approximately one in six adults in Western Countries, and this proportion increases rapidly with increasing age. Over the last 25 years, while the Australian population has grown less than 40%, the number of Australians being treated with dialysis or a kidney transplant has grown more than 400%. Data from the Australian Bureau of statistics collected between 1997 and 1999 shows that approximately one in 10 death certificates listed kidney disease as the underlying or as an associated cause of death. The true contribution of kidney disease to premature mortality is likely to be significantly higher*. Australia's annual spending on end stage kidney disease (ESKD) is $750 million, which is increasing by $50 million each year. This is just a small proportion of the total costs associated with kidney disease in this country. PROGRESS was completed in 2001 and had a direct clinical impact for more than 50 million individuals with cerebrovascular disease worldwide. Results showed that blood pressure lowering reduced the risk of stroke by a quarter among patients with a history of cerebrovascular disease. Many further papers documenting the effects of treatment on other important outcomes, such as preventing heart attacks and the development of dementia, have now been published. Research Australia |
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| Related Chronic Kidney Disease Current Events and Chronic Kidney Disease News Articles Women with chronic kidney disease more likely than men to go undiagnosed Woman are at particular risk of their primary care physicians delaying diagnosis of chronic kidney disease (CKD), according to a paper being presented at the American Society of Nephrology's 42nd Annual Meeting and Scientific Exposition in San Diego, California. For dialysis patients, skinny is dangerous Dialysis patients with low body fat are at increased risk of death-even compared to patients at the highest level of body fat percentage, according to research being presented at the American Society of Nephrology's 42nd Annual Meeting and Scientific Exposition in San Diego. Link between depression, early stages of chronic kidney disease found by researchers One in five patients with chronic kidney disease is depressed, even before beginning long-term dialysis therapy or developing end-stage renal disease, UT Southwestern Medical Center researchers have found. Protein excreted in urine may be help in diagnosing kidney disease caused by HIV New data collected at Columbia University Medical Center and by the Mount Sinai School of Medicine are helping researchers understand the extent to which a certain protein - NGAL - can play a significant role in marking chronic kidney disease resulting from HIV while at the same time distinguishing nephropathy from more common causes such as diabetes and hypertension. A first choice of renal function tests in hepatectomy patients Although creatinine clearance (Ccr) has been measured clinically by a simple method as a preoperative renal function test, Ccr is not strictly equal to glomerular filtration rate (GFR). Study finds novel genetic risk factors for kidney disease A team of researchers from the United States, the Netherlands and Iceland has identified three genes containing common mutations that are associated with altered kidney disease risk. Robotic approach to urothelial cancer of the kidney proves to be beneficial for patients Robotic trained surgeons at Fox Chase Cancer Center in Philadelphia presented a new and novel approach to surgically treat urothelial cancer (in the lining of the bladder or kidney) today at the American Urological Association's Annual Meeting. Test predicts who will develop end-stage renal disease Measuring kidney function by assessing two different factors-glomerular filtration rate (GFR) and urinary albumin levels-helps determine which patients with chronic kidney disease (CKD) will develop end-stage renal disease (ESRD). Proteins from garden pea may help fight high blood pressure, kidney disease Researchers in Canada are reporting that proteins found in a common garden pea show promise as a natural food additive or new dietary supplement for fighting high blood pressure and chronic kidney disease (CKD). Those potentially life-threatening conditions affect millions of people worldwide. For old or young dialysis patients, AV fistulas remain pure gold A new study shows that for those individuals with chronic kidney disease, it doesn't matter if you're young or old: arteriovenous (AV) fistulas remain the gold standard for maintaining access to one's circulatory system to provide life-sustaining dialysis. More Chronic Kidney Disease Current Events and Chronic Kidney Disease News Articles |
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