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Analysis of breast and colon cancer genes finds many areas of differences between tumors
October 12, 2007Researchers from University Hospitals (UH) Ireland Cancer Center and Case Western Reserve University School of Medicine are part of a new national study that has analyzed more than 18,000 genes, including 5,000 previously unmapped genes, from breast and colorectal tumors. The study, published online by the journal Science on Oct. 11, shows a great number of genetic differences between breast and colon cancer tumors, leading the researchers to conclude that new drugs must be developed that can hit these newly identified genetic targets in a manner specific to each different individual's tumor.
Sanford Markowitz, M.D., Ph.D., the Ingalls Professor of Cancer Research at the UH Ireland Cancer Center and Case Western Reserve University, said, "The new insights gained are important in that they indicate there is great genetic diversity from one tumor to the next. Only a handful of genes are common targets for damage, and it will accordingly be necessary to develop a panel of drugs that target specific mutant genes in order to be able to provide individualized cancer treatment to different individual patients."
These results also have potential for tumor diagnosis, according to the researchers.
University Hospitals of Cleveland
University Hospitals of Cleveland
Cancer Genes Current Events and Cancer Genes News RSSScience teams at Cold Spring Harbor Laboratory identify 13 new tumor-suppressor genes in liver cancer
Over the years, hunting for cancer-related genes and understanding how they work has been an important, although time-consuming, exercise. At Cold Spring Harbor Laboratory (CSHL), five different research groups have now combined their expertise to speed up the rate of discovering cancer-related genes and validating their function in living animals.
Researchers identify cancer-causing gene in many colon cancers
Demonstrating that despite the large number of cancer-causing genes already identified, many more remain to be found, scientists at Dana-Farber Cancer Institute have linked a previously unsuspected gene, CDK8, to colon cancer.
Protein thought to promote cancer instead functions as a tumor suppressor, researchers report
A protein previously thought to promote colorectal cancer instead suppresses the growth of human cancer cells in culture, researchers at UT Southwestern Medical Center have found.
Researchers find roadmap to next-generation cancer therapies
Pinpointing new targets for cancer treatments is as difficult as finding a needle in a haystack, yet a University of Rochester team has discovered an entire novel class of genes they believe will lead to a greater understanding of cancer cell function and the next generation of effective and less harmful therapies for patients.
Small RNAs can prevent spread of breast cancer
Howard Hughes Medical Institute researchers have identified small pieces of ribonucleic acid (RNA) that suppress the spread of breast cancer to the lungs and bone. The new research shows that the most invasive and aggressive human breast cancer tumors are missing three critical microRNA molecules.
New study reveals for first time how BRCA1 mutations cause breast cancer
An international team of researchers led by Columbia University Medical Center's Herbert Irving Comprehensive Cancer Center and Sweden's Lund University has, for the first time, revealed how mutations in the BRCA1 gene lead to breast cancer. Findings show that one way BRCA1 mutations cause cancer is by knocking out a powerful tumor suppressor gene known as PTEN.
Jefferson Scientists See Breast Cancer Gene Activity from Outside the Body
Researchers at Jefferson Medical College and Jefferson's Kimmel Cancer in Philadelphia have used PET imaging to see hyperactive cancer genes inside breast tumors in laboratory animals, marking the first time such gene activity has been observed from outside the body.
A new mathematical formula for cancer progression
Tumor progression can now be mapped less to mathematical standards and more to individual patients according to a new study by researchers at Harvard and Johns Hopkins Universities.
Genome study charts genetic landscape of lung cancer
An international team of scientists today announced the results of a systematic effort to map the genetic changes underlying lung cancer, the world's leading cause of cancer deaths.
Genome update defines landscape of breast and colon cancers
One year after completing the first large-scale report sequencing breast and colon cancer genes, Johns Hopkins Kimmel Cancer Center scientists have studied the vast majority of protein-coding genes which now suggest a landscape dominated by genes that each are mutated in relatively few cancers.
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