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Innovative 3D-imaging technique captures brain damage linked to Alzheimer's disease
October 12, 2007Alzheimer's patients have significantly more cortical damage than those with mild cognitive impairment
FINDINGS: Using an advanced three-dimensional mapping technique developed by UCLA researchers, the team analyzed magnetic resonance imaging data from 24 patients with amnestic mild cognitive impairment (MCI) and 25 others with mild Alzheimer's disease. Patients in both categories exhibit progressive brain atrophy, with most MCI patients showing the pathologic changes characteristic of Alzheimer's. MCI patients slip into dementia at a rate of 10 to 15 percent each year. The research team found that patients with mild Alzheimer's had 10 to 20 percent more atrophy in most cortical areas than did MCI patients.
IMPACT: The research showed the striking differences in cortical damage between amnestic MCI and mild Alzheimer's, and demonstrated that this innovative three-dimensional mapping technique greatly outperforms other popular 3D imaging techniques such as voxel based morphometry
University of California - Los Angeles
University of California - Los Angeles
Cognitive Impairment Current Events and Cognitive Impairment News RSSRapid Screening Test Developed to Detect Early Alzheimer's Disease
With millions of baby boomers entering late adulthood, the number of patients with Alzheimer's disease (AD) is expected to drastically rise over the next several decades.
Getting lost -- a newly discovered developmental brain disorder
Feeling lost every time you leave your home? You may not be as alone as you think.
Genetic Variants Associated with Vitamin B12
Researchers at the Harvard School of Public Health (HSPH) and their collaborators at Tufts University and the National Cancer Institute (NCI) have identified a common genetic influence on B12 vitamin levels in the blood, suggesting a new way to approach the biological connections between an important biochemical variable and deficiency-related diseases.
Rhode Island Hospital study finds link between obesity, type 2 diabetes and neurodegeneration
New research from Rhode Island Hospital found that obesity and Type 2 Diabetes Mellitus (T2DM) can contribute to mild neurodegeneration with features common with Alzheimer's disease (AD) - the first study to show that obesity can cause neurodegeneration.
Age-related memory loss tied to slip in filtering information quickly
Scientists have identified a way in which the brain's ability to process information diminishes with age, and shown that this break down contributes to the decreased ability to form memories that is associated with normal aging.
Study finds B-vitamin deficiency may cause vascular cognitive impairment
A deficiency of B-vitamins may cause vascular cognitive impairment, according to a new study. Researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) at Tufts University used an experimental model to examine the metabolic, cognitive, and microvascular effects of dietary B-vitamin deficiency.
Study examines testing model to predict and diagnose new cases of dementia
A report published by researchers at Albert Einstein College of Medicine of Yeshiva University in the August 20 issue of JAMA suggests that measuring how much an individual's performance varies across several neuropsychological tests enhances the accuracy of predicting whether older adults will develop dementia.
PET scans may help assess presence of brain plaques related to Alzheimer's disease
A type of positron emission tomography (PET) scanning may be useful in a non-invasive assessment of the formation of Alzheimer's disease-related plaques in the brain, according to small study posted online today that will appear in the October 2008 print issue of Archives of Neurology, one of the JAMA/Archives journals.
Cognitive problems associated with diabetes duration and severity
Individuals with mild cognitive impairment appear more likely to have earlier onset, longer duration and greater severity of diabetes, according to a report in the August issue of Archives of Neurology, one of the JAMA/Archives journals.
U of M researchers find cerebral malaria may be a major cause of brain injury in African children
Researchers at the University of Minnesota have found that cerebral malaria is related to long-term cognitive impairment in one of four child survivors. The research is published in the current issue of the journal Pediatrics.
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