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Insulin signaling and amphetamines
October 16, 2007Abuse of psychostimulants such as amphetamine remains a serious public health concern. Amphetamines mediate their behavioral effects by stimulating dopaminergic signaling throughout reward circuits of the brain. This property of amphetamine relies on its actions at the dopamine transporter (DAT), a presynaptic plasma membrane protein responsible for the reuptake of extracellular dopamine. Recently, researchers have revealed the novel ability of insulin signaling pathways in the brain to regulate DAT function as well as the cellular and behavioral actions of amphetamine. In a new study published in the open-access journal PLoS Biology, Aurelio Galli, Jason Williams and colleagues used a model of Type I diabetes in rats to uncover how insulin signaling regulates DAT-mediated amphetamine effects. They show that by depleting insulin, or through selective inhibition of insulin signaling, they can severely attenuate amphetamine-induced dopamine release and impair DAT function. This study verifies in vivo that insulin signaling can dynamically influence the neuronal effects of amphetamine-like psychostimulants. Therefore, the insulin signaling pathway, through its unique regulation of brain dopamine, may be targeted for the treatment of amphetamine abuse.
Public Library of Science
Amphetamine Current Events and Amphetamine News RSSLocal health investigation sheds light on gastroschisis birth defect
Results of an investigation conducted by University of Nevada, Reno researchers, public health officials and area physicians published this week in the Archives of Pediatrics & Adolescent Medicine, indicate that Washoe County experienced a cluster of a particular birth defect, gastroschisis, during the period April 2007 - April 2008.
Vyvanse CII significantly improved ADHD symptoms for children 13 hours after administration
Shire plc (LSE: SHP, NASDAQ: SHPGY), the global specialty biopharmaceutical company, today announced that a study published online in the peer-reviewed journal Child and Adolescent Psychiatry and Mental Health found once-daily Vyvanse® (lisdexamfetamine dimesylate) CII significantly reduced the symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD) in children aged 6 to 12 from the first time point measured (1.5 hours) up to the last time point assessed (13 hours) after administration.
Chinese slimming capsules
Taking herbal food supplements is certainly not free of risk.
Phasic firing of dopamine neurons is key to brain's prediction of rewards
Researchers are one step closer to understanding the neurobiology that allows people to successfully learn motivated behaviors by associating environmental cues with rewarding outcomes, according to a study published yesterday in the Proceedings of the National Academy of Sciences' online Early Edition.
Risk takers, drug abusers driven by decreased ability to process dopamine
For risk-takers and impulsive people, New Year's resolutions often include being more careful, spending more frugally and cutting back on dangerous behavior, such as drug use. But new research from Vanderbilt finds that these individuals--labeled as novelty seekers by psychologists--face an uphill battle in keeping their New Year's resolutions due to the way their brains process dopamine.
Sugar can be addictive, Princeton scientist says
A Princeton University scientist will present new evidence today demonstrating that sugar can be an addictive substance, wielding its power over the brains of lab animals in a manner similar to many drugs of abuse.
ADHD medications do not cause genetic damage in children
In contrast to recent findings, two of the most common medications used to treat attention deficit hyperactivity disorder (ADHD) do not appear to cause genetic damage in children who take them as prescribed, according to a new study by researchers at the National Institutes of Health (NIH) and Duke University Medical Center.
Pitt research identifies new target in brain for treating schizophrenia
Research from the University of Pittsburgh could expand the options for controlling schizophrenia by identifying a brain region that responds to more than one type of antipsychotic drug.
VYVANSE provided behavior, inattention and math test score improvements in children with ADHD
Shire plc (LSE: SHP, NASDAQ: SHPGY), the global specialty biopharmaceutical company, today announced results from a 13-hour analog classroom study in school-aged children aged 6 to 12 years with Attention Deficit Hyperactivity Disorder (ADHD).
Singing to females makes male birds' brains happy
The melodious singing of birds has been long appreciated by humans, and has often been thought to reflect a particularly positive emotional state of the singer.
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On Speed: The Many Lives of Amphetamine by Nicholas Rasmussen (Author) Life in the Fast Lane: The author on the CHE Uppers. Crank. Bennies. Dexies. Greenies. Black Beauties. Purple Hearts. Crystal. Ice. And, of course, Speed. Whatever their street names at the moment, amphetamines have been an insistent force in American life since they were marketed as the original antidepressants in the 1930s. On Speed tells the remarkable story of their rise, their fall, and their surprising resurgence. Along the way, it discusses the influence of pharmaceutical marketing on medicine, the evolving scientific understanding of how the human brain works, the role of drugs in maintaining the social order, and the centrality of pills in American life. Above all, however, this is a highly readable biography of a very popular drug. And it is a riveting story. ... | |
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Speed, Ecstasy, Ritalin: The Science of Amphetamines by Leslie Iversen (Author) Amphetamines have had a relatively short, though chequered history. From their use in wartime, their abuse by the beat generation, up to the popularity of Ecstasy in the late 20th century, many have found amphetamines an enjoyable, though unpredictable, stimulant. More than that though, amphetamine-based treatments have been found to have beneficial effects for those suffering from attention deficit disorders, and are now widely prescribed in the US and elsewhere as a treatment for children and adults. What is the truth behind these medical claims? What are the real effects of stimulants like Ecstasy? Just how harmful are amphetamines? In this book, a leading authority on psychoactive drugs explores the uses and abuses of amphetamines. Starting with a look at the origins of... |
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5-Panel Drug Test Cup for Marijuana, Cocaine, Opiates, Amphetamine and Methamphetamine w Adulterant Detection by Instant Technologies This five-Drug Test Cup tests for Marijuana, Opiates (such as heroin), Cocaine. Amphetamine, and Methamphetamine. This FDA cleared cup is the most popular current drug test with clinics, governmental agencies and corporations. It uses immunoassay technology, which is the same as a regular lab test. The cup has built in adulterate detection, to discourage attempts to fool the test by adding foreign compounds, such as bleach or soap, or diluting it. The cup results are easy to photocopy, as the test result area is flat, as shown in the illustration. |
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Amphetamine Syntheses: Industrial by Otto Snow (Author) Amphetamine Syntheses (1998) was a global blockbuster. The new and improved Industrial edition is now available, jam packed with state of the art drug chemistry, hot new formulas written by some of the greatest minds of the 20th century. Small town mom and pop labs across America to the multi-ton labs of global organized crime, how they make drugs and what they use to make them. Otto has put together the most explicit syntheses on the bulk production of psychedelic amphetamines, precursors and reductions. MDA, MDMA (XTC), DOB, TMA, PMA, MDEA (Eve), DOM (STP) & other popular stimulants, eg. methylcathinone, phenetermine, aminorex, ephedrine. It is easy reading yet, explicit, hardcore, psychedelic amphetamine chemistry. eg. Methylcathinone and other psycho-stimulants from non-list... |
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Aural Amphetamine: Metallica and the Dawn Of Thrash Starring: Malcolm Dome, Joel McIver, Jeff Duran, Lonn Friend While Heavy Metal is often accused of being static and conservative, in truth it is a radical form that regularly re-invents itself, and one which attracts generation after generation of musicians willing to learn from the past, but hungry to evolve the f |
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Ten 6-Drug Urine Test Kits for Amphetamine, Cocaine, Marijuana, Methamphetamine, Opiates and Benzodiazepines by USHealthTests.com |
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Skateboard AMPHETAMINE ABEC 5 BEARINGS Skateboards by Amphetamine Like the name states, these are stimulants for your wheels! Light synthetic oil, Delrin Crowns, Rubber Serviceable Shields are a few of the things that makes these bearings awesome. These are rated ABEC 5. |
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Amphetamine Steve Wynn (Primary Contributor) |
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Advanced Techniques of Clandestine Psychedelic and Amphetamine Manufacture Second Edition by Uncle Fester (Author) I begin this new second edition with updated scams and schemes for obtaining chemicals, and move onto the latest techniques for extracting ephedrine or pseudoephedrine from pills or herbal ephedra. Then the book really shifts into high gear as I detail a series of new and high yielding meth recipes which don't require obtaining difficult materials such as iodine, red P, or anhydrous ammonia. These new methods are all easily supplied off the hardware store shelves. I follow this with an examination of the use of the amino acid phenylalanine, found off the shelf at health food stores, as an alternative starting material rather than using ephedrine or pseudoephedrine. Finally, Mr. X writes from the federal pen detailing the mistakes his fellow inmates made which landed them in their... |
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Hairconfirm- Business Hairconfirm Business- Detecting For Marijuana, Amphetamines, Cocaine, Methamphetamine, Opiates, Phencyclidine, (1 package) by Hairconfirm- Business |
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