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The latest about male infertility and testosterone from NewYork-Presbyterian/Weill Cornell
October 18, 2007Two reports from physician-scientists at NewYork-Presbyterian Hospital/Weill Cornell Medical Center shed new light on male infertility. A first report shows that a common cause of male infertility -- varicoceles, or varicose veins in the scrotum -- also results in a depletion of testosterone. In a second related finding, researchers demonstrate that once a common, simple surgery is used to treat varicoceles and thereby restore fertility, testosterone levels are also improved.
Dr. Marc Goldstein, Professor of Urology and Reproductive Medicine at Weill Cornell Medical College and attending urologist at NewYork-Presbyterian/Weill Cornell, has presented his novel research at the 2007 annual meeting of the American Society for Reproductive Medicine (ASRM) in Washington, D.C.
"People often forget or often don't realize that the testes have two purposes," says Dr. Goldstein, who was also awarded the prestigious Howard and Georgeanna Jones Life Time Achievement Award by the American Fertility Association. "One is the production of the sex cells (sperm), and the other is to produce testosterone."
In his research, Dr. Goldstein hypothesized, and later found that, the presence of varicoceles causes significantly lower testosterone levels. He also observed that following varicocele removal, testosterone levels are greatly improved -- up to 100 percent -- in more than two-thirds of the men studied.
With impaired testosterone production, males may experience andropause, analogous to menopause (lowered estrogen levels) in women. A man may have a lowered sex drive, the inability to have erections, lowered muscle strength and energy level, and even depression. Also, affected men are more prone to osteopenia and osteoporosis, causing weakened bones.
Testosterone production is lowered when varicoceles become enlarged and twist around the testis of men. The condition can be hereditary and is found in 15 percent of all males; it also leads to a lowered sperm count and quality.
Thirty-five percent of all cases of primary infertility (first pregnancy attempt) and 80-percent of secondary infertility (attempts at pregnancy following a successful impregnation) are due to varicoceles.
Dr. Goldstein, a pioneer in urology surgery, helped to invent the microsurgery procedure now considered the standard in the treatment and removal of varicoceles.
Varicoceles begin forming at puberty and most doctors do not screen patients during routine check-ups.
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
In his research, Dr. Goldstein hypothesized, and later found that, the presence of varicoceles causes significantly lower testosterone levels. He also observed that following varicocele removal, testosterone levels are greatly improved -- up to 100 percent -- in more than two-thirds of the men studied.
With impaired testosterone production, males may experience andropause, analogous to menopause (lowered estrogen levels) in women. A man may have a lowered sex drive, the inability to have erections, lowered muscle strength and energy level, and even depression. Also, affected men are more prone to osteopenia and osteoporosis, causing weakened bones.
Testosterone production is lowered when varicoceles become enlarged and twist around the testis of men. The condition can be hereditary and is found in 15 percent of all males; it also leads to a lowered sperm count and quality.
Thirty-five percent of all cases of primary infertility (first pregnancy attempt) and 80-percent of secondary infertility (attempts at pregnancy following a successful impregnation) are due to varicoceles.
Dr. Goldstein, a pioneer in urology surgery, helped to invent the microsurgery procedure now considered the standard in the treatment and removal of varicoceles.
Varicoceles begin forming at puberty and most doctors do not screen patients during routine check-ups.
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Testosterone Current Events and Testosterone News RSSHeart and bone damage from low vitamin D tied to declines in sex hormones
Researchers at Johns Hopkins are reporting what is believed to be the first conclusive evidence in men that the long-term ill effects of vitamin D deficiency are amplified by lower levels of the key sex hormone estrogen, but not testosterone.
Pilot study relates phthalate exposure to less-masculine play by boys
A study of 145 preschool children reports, for the first time, that when the concentrations of two common phthalates in mothers' prenatal urine are elevated their sons are less likely to play with male-typical toys and games, such as trucks and play fighting.
Hormone that affects finger length key to social behavior
The hormones, called androgens, are important in the development of masculine characteristics such as aggression and strength.
Postmenopausal women with higher testosterone levels
Postmenopausal women who have higher testosterone levels may be at greater risk of heart disease, insulin resistance and the metabolic syndrome compared to women with lower testosterone levels.
Fetal study highlights impact of stress on male fertility
Exposure to a combination of excess stress hormones and chemicals while in the womb could affect a man's fertility in later life, a study suggests.
Studies examine how living conditions impact reproductive health
When costs outweigh benefits, successful pregnancies are less likely to occur. Life is all about tradeoffs and recently published research by Virginia J. Vitzthum, a senior scientist at Indiana University's Kinsey Institute for Research in Sex, Gender, and Reproduction, and professor in the IU College of Arts and Sciences' Department of Anthropology, has shown that during periods of intense labor and low food intake, rates of early pregnancy loss can more than double.
BUSM researchers propose a relationship between androgen deficiency and cardiovascular disease
Researchers from Boston University School of Medicine (BUSM) in collaboration with researchers from Lahey Clinic Northshore, Peabody, Mass., believe that androgen deficiency might be the underlying cause for a variety of common clinical conditions, including diabetes, erectile dysfunction, metabolic syndrome and cardiovascular disease (CVD).
Prostate cancer patients on hormone therapy at increased risk for various heart diseases
New research has found that hormone therapy used to treat men with advanced prostate cancer is associated with an increased chance of developing various heart problems. Some choices of therapy appear, however, to be less risky than others.
Obesity increases risk of prostate cancer recurrence for both blacks and whites
A new look at a large database of prostate cancer patients shows that obesity plays no favorites when it comes to increasing the risk of recurrence after surgery: Being way overweight is equally bad for blacks and whites, say researchers at Duke University Medical Center.
Life and death in the living brain
Like clockwork, brain regions in many songbird species expand and shrink seasonally in response to hormones. Now, for the first time, University of Washington neurobiologists have interrupted this natural "annual remodeling" of the brain and have shown that there is a direct link between the death of old neurons and their replacement by newly born ones in a living vertebrate.
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