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Researchers underscore limitations of genetic ancestry tests
October 19, 2007Urge caution when interpreting results
AUSTIN, Texas-Although many people rely on commercially available genetic tests for insights into their ancestry, the tests have significant limitations according to Deborah Bolnick, assistant professor of anthropology at The University of Texas at Austin.
In "The Science and Business of Genetic Ancestry Testing," which appears in the Oct. 19 issue of Science, Bolnick and 13 researchers from universities across the nation call upon the scientific community to better educate the public about the limitations of the tests, and urge consumers to approach the tests with caution.
At least two dozen companies market genetic ancestry tests, which typically cost between $100 and $900, to help consumers determine the origins of their ancestors. More than 460,000 people have purchased the tests during the past six years and public interest is growing.
The researchers argue that the assumptions and limitations of the tests make them less informative than many realize, and commercialization has led to misleading practices that reinforce misconceptions.
Some of the tests' limitations identified by Bolnick and her co-authors include:
* Most tests trace only a few of your ancestors and a small portion of your DNA,
* Tests are unlikely to identify all of the groups or locations around the world where a test-taker's relatives are found,
* Tests may report false negatives or false positives,
* Limited sample databases mean test results are subject to misinterpretation,
* There is no clear connection between DNA and racial/ethnic identity,
* Tests cannot determine exactly where ancestors lived or what ethnic identity they held.
Consumers often have deeply personal reasons for taking the tests. Some hope to validate genealogical records or fill in gaps in family histories. Others are searching for a connection to specific groups or places in Eurasia or Africa. Many African Americans hope the tests will help them trace ancestral links lost during the transatlantic slave trade. Other Americans have taken the tests in hope of obtaining Native American tribal affiliation or to challenge tribal membership decisions. However, an individual's social or ethnic identity does not always match his or her genetic ancestry.
"Not all companies make clear the limitations and assumptions underlying these tests," Bolnick said. "Because it is important for consumers to understand what the tests can and cannot tell them, we are encouraging professional genetic and anthropological associations to develop policy guidelines regarding genetic ancestry testing."
University of Texas at Austin
At least two dozen companies market genetic ancestry tests, which typically cost between $100 and $900, to help consumers determine the origins of their ancestors. More than 460,000 people have purchased the tests during the past six years and public interest is growing.
The researchers argue that the assumptions and limitations of the tests make them less informative than many realize, and commercialization has led to misleading practices that reinforce misconceptions.
Some of the tests' limitations identified by Bolnick and her co-authors include:
* Most tests trace only a few of your ancestors and a small portion of your DNA,
* Tests are unlikely to identify all of the groups or locations around the world where a test-taker's relatives are found,
* Tests may report false negatives or false positives,
* Limited sample databases mean test results are subject to misinterpretation,
* There is no clear connection between DNA and racial/ethnic identity,
* Tests cannot determine exactly where ancestors lived or what ethnic identity they held.
Consumers often have deeply personal reasons for taking the tests. Some hope to validate genealogical records or fill in gaps in family histories. Others are searching for a connection to specific groups or places in Eurasia or Africa. Many African Americans hope the tests will help them trace ancestral links lost during the transatlantic slave trade. Other Americans have taken the tests in hope of obtaining Native American tribal affiliation or to challenge tribal membership decisions. However, an individual's social or ethnic identity does not always match his or her genetic ancestry.
"Not all companies make clear the limitations and assumptions underlying these tests," Bolnick said. "Because it is important for consumers to understand what the tests can and cannot tell them, we are encouraging professional genetic and anthropological associations to develop policy guidelines regarding genetic ancestry testing."
University of Texas at Austin
Genetic ancestral testing cannot deliver on its promise, study warns
For many Americans, the potential to track one's DNA to a specific country, region or tribe with a take-home kit is highly alluring. But while the popularity of genetic ancestry testing is rising - particularly among African Americans - the technology is flawed and could spawn unwelcome societal consequences, according to researchers from several institutions nationwide, including the University of California, Berkeley.
Computer program traces ancestry using anonymous DNA samples
A group of computer scientists, mathematicians, and biologists from around the world have developed a computer algorithm that can help trace the genetic ancestry of thousands of individuals in minutes, without any prior knowledge of their background.
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