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Percutaneous valve therapy: is it safe and effective?
October 24, 2007Researchers at TCT 2007, the annual scientific symposium of the Cardiovascular Research Foundation (CRF), will present new studies evaluating a rapidly advancing field within interventional cardiology: percutaneous procedures to repair and replace defective heart valves.
Percutaneous valve procedures, which are currently approved only in Europe, are under study in the U.S. In particular, researchers are studying the safety and effectiveness of the devices being used and the techniques used to implant them, as well as the profile of patients who should receive them.
Several studies analyzing the safety and efficacy of percutaneous valve therapies will be presented at TCT 2007:
* High-risk patients receive life-saving valve replacement
In a study of 85 patients at high-risk for surgery with stenotic aortic valves, scientists led by John Webb, MD, FACP(C) and Sanjeevan Pasupati, MBChB, FRACP of St. Paul's Hospital, Vancouver, BC, Canada, describe the first-in-man implantations of the transarterial Percutaneous Aortic Valve (PAV). In these patients, transarterial PAV implantation produced clinical improvements that were sustained at 1 year.
* Aortic valve replacement
A team led by Susheel Kodali, MD, of Columbia University, New York, NY, reported mid-term results from the U.S. transcather aortic valve replacement experience. Between December 2005 and November 2006, 55 patients were enrolled. The team concluded that in high-surgical-risk patients, percutaneous aortic valve replacement provides sustained symptom improvement for at least 6-12 months. One-year survival (72.8%) was limited primarily by pre-existing conditions unrelated to the valve implant in this high-risk population.
* Successful left ventricle remodeling with new percutaneous valve device
Mitral insufficiency (abnormal blood leakage from the left ventricle through the mitral valve into the left atrium), when severe, may lead to progressive left ventricular enlargement and heart failure. Repair of the leaking mitral valve may improve the function of the failing heart (reverse LV remodeling). A device known as the Mitra Clip was found to be effective, demonstrating significant clinical improvements in patients with mitral regurgitation who had Charlotte, NC.
In addition to these presentations, panel discussions were held on Sunday October 21, "Percutaneous Mitral Valve Repair and Replacement," led by Ted Feldman, MD, Northwestern University, Feinberg School of Medicine. These panels discussed the various types of and approaches.
Cardiovascular Research Foundation
* High-risk patients receive life-saving valve replacement
In a study of 85 patients at high-risk for surgery with stenotic aortic valves, scientists led by John Webb, MD, FACP(C) and Sanjeevan Pasupati, MBChB, FRACP of St. Paul's Hospital, Vancouver, BC, Canada, describe the first-in-man implantations of the transarterial Percutaneous Aortic Valve (PAV). In these patients, transarterial PAV implantation produced clinical improvements that were sustained at 1 year.
* Aortic valve replacement
A team led by Susheel Kodali, MD, of Columbia University, New York, NY, reported mid-term results from the U.S. transcather aortic valve replacement experience. Between December 2005 and November 2006, 55 patients were enrolled. The team concluded that in high-surgical-risk patients, percutaneous aortic valve replacement provides sustained symptom improvement for at least 6-12 months. One-year survival (72.8%) was limited primarily by pre-existing conditions unrelated to the valve implant in this high-risk population.
* Successful left ventricle remodeling with new percutaneous valve device
Mitral insufficiency (abnormal blood leakage from the left ventricle through the mitral valve into the left atrium), when severe, may lead to progressive left ventricular enlargement and heart failure. Repair of the leaking mitral valve may improve the function of the failing heart (reverse LV remodeling). A device known as the Mitra Clip was found to be effective, demonstrating significant clinical improvements in patients with mitral regurgitation who had Charlotte, NC.
In addition to these presentations, panel discussions were held on Sunday October 21, "Percutaneous Mitral Valve Repair and Replacement," led by Ted Feldman, MD, Northwestern University, Feinberg School of Medicine. These panels discussed the various types of and approaches.
Cardiovascular Research Foundation
Aortic Valve Replacement Current Events and Aortic Valve Replacement News RSSFew complications 1 year after aortic valve implantation
Research presented at the 21st annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium, sponsored by the Cardiovascular Research Foundation (CRF), demonstrated an "exceptionally low" rate of complications one year after implantation of transcatheter aortic valve prostheses.
Valve implantation on the beating heart
Transcatheter valve implantation is a newly developed technique for the curative treatment of high-grade aortic stenosis. It is likely to be of benefit especially to elderly, multimorbid patients for whom the risk of open heart surgery would be too great.
Diseased Heart Valve Replaced Through Small Chest Incision
When 91-year-old Irvin Lafferty was diagnosed with severe blockage of his heart valve-hardening that is formally known as aortic valve stenosis-open-heart surgery was out of the question.
Minimally invasive aortic valve bypass benefits high-risk elderly patients
An uncommonly used surgical procedure that bypasses a narrowed aortic valve, rather than replacing it, effectively restores blood flow from the heart to the rest of the body and gives high-risk patients a safe alternative to conventional valve surgery.
Use of hydrocortisone reduces incidence of atrial fibrillation after cardiac surgery
Patients who receive corticosteroids after cardiac surgery have a significantly lower risk of atrial fibrillation in the days following the surgery.
Experience backs early heart valve replacement
Patients with leaky aortic heart valves appear to do better when the valves are replaced before significant symptoms develop.
Percutaneous aortic valve replacement
Percutaneous aortic valve replacement is becoming a reality and brings new hope for a number of patients who cannot currently be treated with traditional surgical techniques.
ESC Congress 2003: Lipid-lowering therapy for valve prostheses
IMPORTANT: This press release accompanies a poster or oral session given at the ESC Congress 2003. Written by the investigator himself/herself, this press release does not necessarily reflect the opinion of the European Society of Cardiology ESC Congress 2003: In our study we have demonstrated that lipid-lowering drugs (statins) can reduce the process of degeneration of the bioprosthetic aortic valves. Aortic valve replacement is one of the most often performed cardiac surgery procedures nowadays: 70 people per million of the general population undergo aortic valve replacement in the UK each year, a rate that is fairly common in the developed world. Two main types of valve prosthesis are a
ESC Congress 2003: C-reactive protein, an inflammatory biomarker, predicts progression of aortic valve stenosis
IMPORTANT: This press release accompanies a poster or oral session given at the ESC Congress 2003. Written by the investigator himself/herself, this press release does not necessarily reflect the opinion of the European Society of Cardiology Aortic stenosis (AS) is the narrowing or obstruction of the heart's aortic valve, which prevents it from opening properly and blocks the flow of blood from the left ventricle to the aorta. AS is common in the ageing population and has become the most frequent native valve disease in Europe. AS when severe, may cause left heart failure, fainting or angina, but the natural progression of less severe degrees is highly variable. The risk factors for the d
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