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Study: Fountain of youth for your heart?
November 05, 2007An age-related decline in heart function is a risk factor for heart disease in the elderly. While many factors contribute to a progressive age-related decline in heart function, alterations in the types of fuels the heart uses to produce energy also play important roles. Jason Dyck and his research team at the University of Alberta have been studying the types of fuels used by the heart in young and aged mice. The young healthy heart normally used a balance of fat and sugar to generate energy to allow the heart to beat and pump blood efficiently. However, as the heart ages the ability to use fat as an energy source deteriorates. This compromises heart function in the elderly. Interestingly, at a time when the heart is using less fat for energy, Dyck has shown that a protein that is responsible for transporting fat into the contractile cells of the heart actually increases. Based on this finding, Dyck proposed that the mismatch between fat uptake and fat use in the heart could lead to an accumulation of fat in the heart resulting in an age-related decrease in heart function.
Using a genetically engineered mouse that is deficient in a protein that is responsible for transporting fat into the cells of the heart, Dyck studied these mice as they aged. These genetically altered mice have no choice but to mainly use sugar as a fuel source because they lack the protein that allows them to use fat as a primary fuel source. In an exciting new finding, Dyck showed that old genetically modified mice did not accumulate fat in their hearts, as did ordinary mice. In addition, Dyck and his team showed that these old genetically altered mice out-performed ordinary old mice on a treadmill test, were completely protected from age-related decline in heart function, and in many ways their hearts looked and performed like hearts from a young mouse. His findings suggest that the protein responsible for transporting fat into the contractile cells of the heart may be a candidate for drug inhibition and that this drug could protect the heart from aging.
This research holds great promise for human beings. Dyck hopes it will lead to the development of medications that inhibit the uptake of fatty acids into the heart and prevent and/or reverse the effects of aging on the heart muscle.
University of Alberta
University of Alberta
Heart Function Current Events and Heart Function News RSSDrug for erectile dysfunction improves heart function in young heart-disease patients
Heart function significantly improved in children and young adults with single-ventricle congenital heart disease who have had the Fontan operation following treatment with sildenafil, a drug used to treat erectile dysfunction and pulmonary hypertension, say researchers from The Children's Hospital of Philadelphia.
Protein changes in heart strengthen link between Alzheimer's disease and chronic heart failure
A team of U.S., Canadian and Italian scientists led by researchers at Johns Hopkins report evidence from studies in animals and humans supporting a link between Alzheimer's disease and chronic heart failure, two of the 10 leading causes of death in the United States.
Tiny particles can deliver antioxidant enzyme to injured heart cells
Researchers at Emory University and the Georgia Institute of Technology have developed microscopic polymer beads that can deliver an antioxidant enzyme made naturally by the body into the heart.
Texas Children's discharges first pediatric patient with implanted mechanical heart device
Texas Children's Hospital is the nation's first pediatric hospital to discharge a child while on an intracorporeal ventricular assist device (VAD), a feat previously accomplished only at adult institutions.
UT Southwestern patient first in North Texas to receive newest-generation heart failure device
UT Southwestern Medical Center patient Michael LeBlanc, 40, is the first in North Texas to receive the newest generation of a mechanical device designed to improve heart function. It will be his lifeline while he awaits a heart transplant.
Canadian cardiology team clears the way for lifesaving breast cancer treatment
A team of Canadian cardiologists, in collaboration with oncologists, are playing an important role in the war against breast cancer Dr. Michael McDonald told the Canadian Cardiovascular Congress 2009, co-hosted by the Heart and Stroke Foundation and the Canadian Cardiovascular Society.
Suppressing a gene in mice prevents heart from aging, preserves its function
Scientists prevented age-related changes in the hearts of mice and preserved heart function by suppressing a form of the PI3K gene, in a study reported in Circulation: Journal of the American Heart Association.
Two treatment innovations improve heart function after heart attack
Supersaturated oxygen (SSO2) administered during catheter-based treatments for heart attack can significantly reduce heart muscle damage, according to a new study reported in Circulation: Cardiovascular Interventions, a journal of the American Heart Association.
New Insights Into Cardiac Aging
Investigators at Burnham Institute for Medical Research (Burnham) have found that the conserved protein d4eBP modulates cardiac aging in Drosophila (fruit flies).
Regular Electrocardiograms May Help Physicians Identify Patients at Risk of Sudden Cardiac Death
QRS duration (QRSd) is one of several measures of heart function recorded during a routine electrocardiogram (ECG).
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The Art and Science of Cardiac Physical Examination: With Heart Sounds and Pulse Wave Forms on CD (Contemporary Cardiology) by Narasimhan Ranganathan (Author), Vahe Sivaciyan (Author), Franklin B. Saksena (Author) A panel of academic clinicians brings the art and science of the clinical cardiac examination to the bedside with a tour de force tutorial on the techniques needed to elicit various physical signs and to interpret them in relation to the patient's symptoms and underlying cardiac condition. Drawing on twenty-five years of teaching and training physicians and physicians-to-be, the authors integrate the physiology, pathophysiology, and mechanisms behind the various physical signs with a thorough and easy-to-use practical approach that makes physician feel more comfortable and competent performing the cardiac physical examination. The authors pay particular attention to the interpretation of the jugular venous pulsations and contour and make the physiology and pathophysiology of the normal... |
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DMC-03 Multi-Function Pedometer (color: ORANGE) by Heart Rate Monitors USA The accuracy is about 96%, we would recommend it for any walking programs looking to obtain important feedback. It features steps, distance in miles, calories. |
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Adee Kaye #AK4094-MG Men's Multi-Function Open Heart Tourbillon Self Winding Automatic Watch (Gold Tone) by Adee Kaye A skeleton watch is a mechanical watch (although occasionally Quartz), in which all of the moving parts are visible through either the cut out dial or and exhibition back. Featuring the brand new watch with open tourbillon window by Adee Kaye. |
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NaturalCare CardiAll, Supports Healthy Heart Function, 60 Capsules by NaturalCare CardiAll is designed to optimize healthy heart and blood vessel function, support normal homocysteine and cholesterol levels already in normal rnage, promote cardiac muscle energy and arterial circulation and enhance oxygen utilization. |
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The Abstraction Of Form And Function The Abandoned Hearts Club (Primary Contributor) |
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Dog Healthy Heart Supplement - Healthy Heart Supplement Help Support Normal Cardiovascular Function in Dogs- 60 Count - Made in USA by NutriVet NutriVet Healthy Heart Supplement liver flavor chewables help support normal cardiovascular function in dogs. Formulated with powerful heart-friendly antioxidants, essential minerals, amino acids and omega-3 essential fatty acids, this exceptional formula helps fight free radicals and reduce normal oxidative stress. Ideal for older dogs. |
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Centrios 18-Function Pulse Heart Rate Monitor (631-8143) (631-8143) by Centrios | |
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Selectmusic Amazing Human Body Vol 2 - Dvd Movie [dvd Movie by Selectmusic Award-winning videos for your home library. Since 1768, the Encyclopedia Britannica has been the world's most respected source of knowledge. Some of the finest educational films and videos ever made are now available through the Encyclopedia Britannica DVD Classics collection. Hundreds of award-winning films and videos cover topics in science, physics, animals, social studies, language arts, health, and more. Includes Muscles: Their Structure and Function The Respiratory System Work of the Heart Genetic Fingerprinting The Ears of King Midas Specifications: Language: English Encoding: All regions Format: Color, full-frame, stereo sound, NTSC Rating: Unrated Subtitles: None Approx Runtime: 110 minutes Other Features: Interactive menus Note: This DVD is Compatible with all... |
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