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In the laboratory, green tea proves a powerful medicine against severe sepsis
November 09, 2007A major component of green tea could prove the perfect elixir for severe sepsis, an abnormal immune system response to a bacterial infection. In a new laboratory study, Haichao Wang, PhD, of The Feinstein Institute for Medical Research, and his colleagues have been studying the therapeutic powers of dozens of Chinese herbal compounds in reversing a fatal immune response that kills 225,000 Americans every year. They found that an ingredient in green tea rescued mice from lethal sepsis - and the findings could pave the way to clinical trials in patients.
The study was published this week in the Public Library of Science, or PLoS-ONE. Dr. Wang had previously discovered a late mediator of sepsis called HMGB1, a substance expressed in the late stages of lethal sepsis. They wanted to figure out a way to block this substance, which they felt would prevent the lethal sepsis process from moving forward. And it worked.
Scientists worldwide have been stumped by sepsis. Even with the most advanced medical techniques available, half of those who develop sepsis die of the massive assault on the body. Several laboratories at the Feinstein Institute are working on sepsis - both on the basic biological level and in patients.
In the latest study, Dr. Wang's group gave a substance in green tea called EGCG to mice in the throes of severe sepsis. The dose was equivalent to 10 cups in a human. Survival jumped from 53 percent in those who didn't receive the green tea substance to 82 percent in those who did. "Clinically, even if we could save five percent of patients, that would be huge," said Dr. Wang. "In this study, we saved 25 percent more animals with the green tea." He said that the green tea component, EGCG, is readily available.
There have been more than 100 papers focusing on this natural substance and its anti-cancer benefits. "This compound prevents HMGB1 from being released by immune cells and it also prevents it from activating immune cells to produce more cytokines," he said. Cytokines are produced by immune cells and act as weapons to defend the body against invaders. "We are hoping to stimulate future interest in clinical studies," said Dr. Wang, who worked on the study in collaboration with Wei Li, PhD, Andrew Sama, MD, chairman of emergency medicine at North Shore University Hospital, and other Feinstein investigators.
North Shore-Long Island Jewish (LIJ) Health System
In the latest study, Dr. Wang's group gave a substance in green tea called EGCG to mice in the throes of severe sepsis. The dose was equivalent to 10 cups in a human. Survival jumped from 53 percent in those who didn't receive the green tea substance to 82 percent in those who did. "Clinically, even if we could save five percent of patients, that would be huge," said Dr. Wang. "In this study, we saved 25 percent more animals with the green tea." He said that the green tea component, EGCG, is readily available.
There have been more than 100 papers focusing on this natural substance and its anti-cancer benefits. "This compound prevents HMGB1 from being released by immune cells and it also prevents it from activating immune cells to produce more cytokines," he said. Cytokines are produced by immune cells and act as weapons to defend the body against invaders. "We are hoping to stimulate future interest in clinical studies," said Dr. Wang, who worked on the study in collaboration with Wei Li, PhD, Andrew Sama, MD, chairman of emergency medicine at North Shore University Hospital, and other Feinstein investigators.
North Shore-Long Island Jewish (LIJ) Health System
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Green Tea Current Events and Green Tea News RSSGreen tea may affect prostate cancer progression
According to results of a study published in Cancer Prevention Research, a journal of the American Association for Cancer Research, men with prostate cancer who consumed the active compounds in green tea demonstrated a significant reduction in serum markers predictive of prostate cancer progression.
Green tea extract shows promise in leukemia trials
Mayo Clinic researchers are reporting positive results in early leukemia clinical trials using the chemical epigallocatechin gallate (EGCG), an active ingredient in green tea.
Go green for healthy teeth and gums
With origins dating back over 4,000 years, green tea has long been a popular beverage in Asian culture, and is increasingly gaining popularity in the United States.
USC study finds that green tea blocks benefits of cancer drug
Contrary to popular assumptions about the health benefits of green tea, researchers at the University of Southern California (USC) have found that the widely used supplement renders a cancer drug used to treat multiple myeloma and mantle cell lymphoma completely ineffective in treating cancer.
Queen's chemist sheds light on health benefits of garlic
Researchers have widely believed that the organic compound, allicin - which gives garlic its aroma and flavour - acts as the world's most powerful antioxidant. But until now it hasn't been clear how allicin works, or how it stacks up compared to more common antioxidants such as Vitamin E and coenzyme Q10, which stop the damaging effects of radicals.
Moderate drinking can reduce risks of Alzheimer's dementia and cognitive decline
Moderate drinkers often have lower risks of Alzheimer's disease and other cognitive loss, according to researchers who reviewed 44 studies. In more than half of the studies, published since the 1990s, moderate drinkers of wine, beer and liquor had lower dementia risks than nondrinkers.
Drink brewed tea to avoid tooth erosion
Today, the average size soft drink is 20 ounces and contains 17 teaspoons of sugar. More startling is that some citric acids found in fruit drinks are more erosive than hydrochloric or sulfuric acid-which is also known as battery acid.
Green tea may delay onset of type 1 diabetes
A powerful antioxidant in green tea may prevent or delay the onset of type 1 diabetes, Medical College of Georgia researchers say.
Brainy genes, not brawn, key to success on mussel beach
It's hard being a mussel: you have to worry about hungry starfish and even hungrier humans, not to mention an environment that can change your body temperature 50 degrees Fahrenheit in just a few hours.
MRI spots DCIS in mice
A new magnetic resonance imaging procedure can detect very early breast cancer in mice, including ductal carcinoma in situ (DCIS), a precursor to invasive cancer. Some of the tumors detected were less than 300 microns in diameter, the smallest cancers ever detected by MRI.
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Bigelow Organic Green Tea, 40-Count Boxes (Pack of 6) by Bigelow Our tea bags are sealed for freshness in airtight, flavor protecting fresh packs to ensure your full enjoyment. USDA organic. Certified 100% Organic. Bigelow Certified 100% Organic Green Tea - tea with a healthy attitude! Mother Nature gave us a wonderful gift when she packed beneficial antioxidants into Green Tea - powerful combatants that protect the body's healthy cells from billions of naturally occurring free radicals, unstable molecules that when left unchecked, may lead to a host of degenerative diseases. Studies show that drinking 2-3 cups of tea may improve your chances of fending off these invaders. But that's only half the story. The Certified 100% Organic tea contained in this package has the added benefits from having been grown by socially-responsible farmers who are... |
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Kirkland Signature Green Tea Matcha Blend, 100% Japanese Tea Leaves, 100 Tea Bags by Kirkland Signature Kirkland Signature Green Tea Matcha Blend, 100% Japanese Tea Leaves, 100 Tea Bags Kirkland Signature Green Tea Matcha Blend Ryokucha. 100% Japanese Tea Leaves. | |
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Yogi Tea, Green Tea Super Anti-Oxidant, Tea Bags, 16-Count Boxes (Pack of 6) by Yogi |
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Green Teas Sampler, 6 tins by Adagio Teas Similar to wine, tea is affected greatly by the climate in which it grows. Differences in soil and weather conditions produce a rich mosaic of tea's many natural flavors. If you have yet to discover the superior flavor of gourmet tea, this is a wonderful introduction to its many green varieties. |
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Bigelow Decaffeinated Organic Green Tea, 40-Count Boxes (Pack of 6) by Bigelow Our tea bags are sealed for freshness in airtight, flavor protecting fresh packs to ensure your full enjoyment. USDA organic. Certified 100% Organic. Bigelow Certified 100% Organic Decaffeinated Green Tea - tea with a healthy attitude! Mother Nature gave us a wonderful gift when she packed beneficial antioxidants into Green Tea - powerful combatants that protect the body's healthy cells from billions of naturally occurring free radicals, unstable molecules that when left unchecked, may lead to a host of degenerative diseases. Studies show that drinking 2-3 cups of tea may improve your chances of fending off these invaders. But that's only half the story. The Certified 100% Organic tea contained in this package has the added benefits from having been grown by socially-responsible farmers... |
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Stash Premium Green Tea, Tea Bags, 20-Count Boxes (Pack of 6) by Stash Green tea is steamed fresh from the garden, preserving its color and natural flavor, leaving it rich in antioxidants. Stash Premium Green is a gentle, contemplative drink blended from top-quality green tea leaves. It brews up golden in the cup, with a slightly sweet flavor. Our Premium Green Tea should be sipped plain. 100% natural ingredients. True teas are made from the dried leaves of the Camellia Sinensis, the tea plant, which was first cultivated in China and found growing wild in India. Chinese monks and European traders introduced it to Japan, Sri Lanka and other countries. Since 1972, Stash has been committed to providing premium quality teas and an unsurpassed tea drinking experience. Stash begins with simply excellent tea leaves from the world's premier tea gardens and all... |
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Applied Nutrition Green Tea Fat Burner with EGCG -200 Softgels by Applied Nutrition Combining Green, White and Orange (black) tea provides a blend of key nutritional compounds (polyphenols, catechins, theaflavins) that support your weight loss efforts. The EGCG content of each tea along with the natural caffeine is scientifically shown to promote fat oxidation (fat burning +++Each of the teas is processed differently resulting in a variety of antioxidants. The EGCG levels in each of the three tea extracts are standardized at 50% to insure that maximum fat burning power is achieved.+++White, Green & Orange Tea Antioxidant Power Antioxidants create a barrier of protection between the cells of our body and the negative impact of everything from environmental pollution to aging. Specifically, antioxidants protect from free radical damage. What are free radicals?+++Free... |
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Matcha Green Tea Powder (1/2 lb.) by Malden Tea Information: Matcha is perhaps the most popular green tea on the market today. The first thing you will notice upon opening the packet is that Matcha is a finely powdered green tea and looks like an emerald colored flour. This characteristic truly sets it apart from other teas. When brewed, the powdered leaf is not strained or left in the pot, but is whisked into a frothy concoction and consumed. Because the leaves themselves are imbibed, brewed Matcha contains higher concentrations of vitamins and antioxidants than most other teas, green, herbal, or otherwise. According to researches done in Japan, brewed Matcha contains nearly 10 times the polyphenols and antioxidants of regular teas, 2 times the antioxidants of a glass of red wine, approximately 9 times the beta-carotene of spinach,... | |
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Yogi Tea, Green Tea Kombucha, Tea Bags, 16-Count Boxes (Pack of 6) by Yogi |
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Green Tea 500 mg 100 Caps by Swanson Premium Brand Green tea has been brewed for centuries throughout Asia where it's revered as a health-promoting tonic. Modern science has discovered the amazing antioxidant power in green tea leaves. A terrific free-radical fighter for whole body protection, each convenient capsule of Swanson Premium Brand Green Tea delivers 500 mg of green tea leaf powder. |
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