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New therapeutic targets in the treatment of ulcerative colitis
November 14, 2007Social, environmental and dietary changes are associated with the changes of disease spectrum in a country. Ulcerative colitis has become a commonly seen disease in China, probably due to extensive consumption of Western foods in recent years. Unfortunately, the etiology and pathogenesis of ulcerative colitis have not been clarified yet. Therefore, no effective etiological treatment is available at present. But a recent study published in issue 44 of the World Journal of Gastroenterology may offer new insight into this difficult-to-treat disease.
A research team from the First Affiliated Hospital of Dalian Medical University's Department of Gastroenterology, China, led by Professor Ying-De Wang, investigated the expression of matrix metalloproteinase-1 (MMP-1) and tumor necrosis factor- ¦Á (TNF-alpha). MMP-1 is a peptidase that degrades the extracellular matrix in the colonic mucosa, while TNF-alpha is an important and harmful inflammatory cytokine produced in macrophages in colon. The research team found that both MMP-1 and TNF-alpha were over expressed in the colonic mucosa of patients with ulcerative colitis. The over expressed MMP-1 excessively degrades the extracellular matrix, and subsequently damages the colonic mucosa and causes ulceration and inflammatory changes in ulcerative colitis, and the over expressed TNF-alpha directly damages the colon mucosa. MP-1 and TNF-alpha proteins have the so-called ˇ°synergistic actionˇ±. The study revealed that the excessively expressed TNF-alpha stimulated MMPs secreting cells to produce more MMP-1, aggravating the mucosa damage. Meanwhile, MMP-1 promoted secretion of TNF-alpha in a positive feedback manner to cause further injury in the mucosa of colon. So it is very likely both MMP-1 and TNF-alpha play a central role in the development of ulcerative colitis.
The results of this study will undoubtedly bring about a new round of research on the pathogenesis and new methods of treating ulcerative colitis. This will be a step toward a promising future in the battle against ulcerative colitis.
World Journal of Gastroenterology
Ulcerative Colitis Current Events and Ulcerative Colitis News RSSM. D. Anderson redefines screening guidelines for breast, cervical and colorectal cancers
Drawing on years of experience in cancer research and patient care, The University of Texas M. D. Anderson Cancer Center released today the most comprehensive, risk-based screening guidelines publicly available to date for breast, cervical and colorectal cancers.
Probiotic Found to Be Effective Treatment for Colitis In Mice
The probiotic, Bacillus polyfermenticus, can help mice recover from colitis, a new study has found.
Discovery of genetic defect may lead to better treatments for common gut diseases
New findings related to an uncommon genetic disorder may impact the diagnosis and treatment of inflammatory bowel disease (IBD), the most common chronic gastrointestinal illness in children and teens. Two million Americans have IBD which involves inflammation of the gastrointestinal tract.
Oxidized form of a common vitamin may bring relief for ulcerative colitis
New research published in the Journal of Leukocyte Biology finds retinoic acid may alleviate ulcerative colitis and similar irritable bowel diseases.
Promising new target emerges for autoimmune diseases
University of Michigan scientists say they have uncovered a fundamentally new mechanism that holds in check aggressive immune cells that can attack the body's own cells.
Subclinical markers predict relapse in juvenile idiopathic arthritis post methotrexate withdrawal
Elevated levels of the inflammatory biomarkers Myeloid Related Protein (MRP) 8/14 predict an increased risk of relapse following withdrawal of methotrexate (MTX) therapy in children with juvenile idiopathic arthritis (JIA) who have achieved inactive disease status.
Electronic Pill Shows Its Smarts by Measuring pH Levels in Digestive Tract
An electronic diagnostic tool called the SmartPill is swallowed by patients in order to take measurements as it travels through the gastrointestinal tract.
Enzyme involved in inflammatory bowel disease discovered at Penn State College of Medicine
Researchers at Penn State College of Medicine, working with biochemists, geneticists and clinicians at the University of Bern, Switzerland and in the United Kingdom, have discovered an enzyme that has a key role in inflammatory bowel disease (IBD).
UCLA cancer researchers first to link intestinal inflammation with systemic chromosome damage
UCLA scientists have linked for the first time intestinal inflammation with systemic chromosome damage in mice, a finding that may lead to the early identification and treatment of human inflammatory disorders.
Chronic diarrhea unresponsive to conventional medication: Are you taking lansoprazole?
Lansoprazole is a proton pump inhibitor which powerfully suppresses gastric acid production and is widely prescribed for chronic use in gastroesophageal reflux disease.
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What to Eat with IBD: A Comprehensive Nutrition and Recipe Guide for Crohn's Disease and Ulcerative Colitis by Tracie M Dalessandro MS RD CDN (Author) From a patient who is also a dietitian... Everything you need to know about nutrition and inflammatory bowel disease including healing foods, recipes, supplements and more. At the age of nineteen, author Tracie Dalessandro was diagnosed with ulcerative colitis and eventually Crohn's disease. After years of trying to heal, Dalessandro realized the power of using diet in conjunction with traditional medicine to control her inflammatory bowel disease (IBD), rather than allowing it to control her. Nutrition became the link between feeling sick and feeling well. What to Eat with IBD: A Comprehensive Nutrition and Recipe Guide for Crohn's Disease and Ulcerative Colitis is an invaluable resource containing the latest nutrition and diet information for those suffering from IBD.... |
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100 Questions & Answers About Crohn's Disease and Ulcerative Colitis: A Lahey Clinic Guide by Andrew S., M.D. Warner (Author), Amy E., M.D. Barto (Author) Whether you’re a newly diagnosed patient, or a friend or relative of someone suffering with Crohns Disease or Ulcerative Colitis, this book offers help. Completely revised and updated,100 Questions & Answers About Crohns Disease and Ulcerative Colitis: A Lahey Clinic Guide, Second Editionprovides authoritative, practical answers to common questions about this condition to help patients and families achieve a greater understanding of all aspects of dealing with Crohns Disease including treatment options, sources of support, and much more. This book is an invaluable resource for anyone coping with the physical and emotional turmoil of this disease. |
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VSL #3 Capsules (60 caps) by Sigma Tau VSL#3 Capsules for Ulcerative Colitis - 60 ea (Refrigerated Item= MUST be Shipped NEXT DAY AIR) |
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Breaking the Vicious Cycle: Intestinal Health Through Diet by Elaine Gloria Gottschall (Author) |
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Crohn's Disease and Ulcerative Colitis: Everything You Need to Know (Your Personal Health) by Fred Saibil (Author) Includes the most recent medical research. Inflammatory Bowel Disease (IBD) includes two chronic conditions known as Crohn's disease and ulcerative colitis. This has remained for too long the secret illness that no one wants to discuss. Although up to 1,000 per 100,000 North Americans have IBD, no one is completely sure what causes it, and there is no known cure. Dr. Fred Saibil, a renowned expert on IBD, provides concise, up-to-date information on common conditions. He describes the normal gastrointestinal system, and then explains what goes wrong when someone has IBD. Crohn's Disease and Ulcerative Colitis also covers: - Signs and symptoms - How the gastrointestinal system works normally and how IBD affects it - Procedures and instruments used to diagnose IBD -... |
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Colitiscope: Living With Crohn's Disease and Ulcerative Colitis by Andrew Tubesing (Author) More of an adventure story than an encyclopedia, this resource for Crohn’s and colitis patients weaves humor with introspection and information with observation. Written by a sufferer of inflammatory bowel disease (IBD), the guide shares common tales and insights while also covering symptoms, medications, and procedures, from a uniquely entertaining viewpoint. Humor and frankness are used as a coping method, helping to illustrate and conquer common difficulties brought on by the chronic illness. |
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