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How can we know early who will benefit from tumor target therapy?
November 26, 2007The precise tailoring of tumor target treatment for patients with cancer is an unmet challenge. The goal is to only administer treatments that have a high probability of being effective. Modern cancer care is critically dependent on imaging technologies, which are used to detect tumors early, when they are easier to treat, and to guide therapy or surgery.
Vascular endothelial growth factor (VEGF) and EGFR inhibitors have become key components of therapies for several tumor types. Close relationships between these two factors exist: VEGF signaling is up-regulated by EGFR expression and, conversely, VEGF up-regulation independent of EGFR signaling seems to contribute to resistance to EGFR inhibition. Therefore, inhibition of both pathways could improve anti-tumor efficacy and overcome resistance to EGFR inhibition.
A research article to be published in the December 7 issue of the World Journal of Gastroenterology addresses this question. The research team, led by Dr. Sun from Minnan PET Center, used FDG PET/CT to monitor early responses, followed by EGF-receptor antibody (Cetuximab) plus recombinant human endostatin (Endostar) treatment.
One conclusion reported by the investigators is that molecular imaging could monitor molecular treatment, and that the combination of EGFR-specific antibodies with VEGF-specific antibodies may be a promising combination for palliative treatment.
Another interesting conclusion is the potential of this novel approach to anticancer therapy. Monitoring responses algorithm by PET/CT will be elucidated by large, ongoing clinical trials. Molecular imaging continues to tell us the exciting results of molecular therapy for cancer.
World Journal of Gastroenterology
One conclusion reported by the investigators is that molecular imaging could monitor molecular treatment, and that the combination of EGFR-specific antibodies with VEGF-specific antibodies may be a promising combination for palliative treatment.
Another interesting conclusion is the potential of this novel approach to anticancer therapy. Monitoring responses algorithm by PET/CT will be elucidated by large, ongoing clinical trials. Molecular imaging continues to tell us the exciting results of molecular therapy for cancer.
World Journal of Gastroenterology
Tumor Current Events and Tumor News RSSRare pancreatic cancer patients may live longer when treated with radiation therapy
Radiation therapy is effective in achieving local control and palliation in patients with pancreatic neuroendocrine tumors (PNTs), despite such tumors being commonly considered resistant to radiation therapy.
Researchers Identify Role of Gene in Tumor Development, Growth and Progression
Virginia Commonwealth University Massey Cancer Center and VCU Institute of Molecular Medicine researchers have identified a gene that may play a pivotal role in two processes that are essential for tumor development, growth and progression to metastasis.
Cancer metabolism discovery uncovers new role of IDH1 gene mutation in brain cancer
Agios Pharmaceuticals today announced that its scientists have established, for the first time, that the mutated IDH1 gene has a novel enzyme activity consistent with a cancer-causing gene, or oncogene.
New cancer target for non-Hodgkin's lymphoma
Physician-scientists from Weill Cornell Medical College have discovered a molecular mechanism that may prove to be a powerful target for the treatment of non-Hodgkin's lymphoma, a type of cancer that affects lymphocytes, or white blood cells.
Laser therapy can aggravate skin cancer
High irradiances of low-level laser therapy (LLLT) should not be used over melanomas.
Common pain relief medication may encourage cancer growth
Although morphine has been the gold-standard treatment for postoperative and chronic cancer pain for two centuries, a growing body of evidence is showing that opiate-based painkillers can stimulate the growth and spread of cancer cells.
Cancers' Sweet Tooth May Be Weakness
The pedal-to-the-metal signals driving the growth of several types of cancer cells lead to a common switch governing the use of glucose, researchers at Winship Cancer Institute of Emory University have discovered.
UCLA researchers create 'fly paper' to capture circulating cancer cells
Just as fly paper captures insects, an innovative new device with nano-sized features developed by researchers at UCLA is able to grab cancer cells in the blood that have broken off from a tumor.
'Cross-talk' mechanism contributes to colorectal cancer
Researchers at the University of Wisconsin-Madison School of Medicine and Public Health have identified a molecular mechanism that allows two powerful signaling pathways to interact and begin a process leading to colorectal tumors.
Thoughtful words help couples stay fighting fit
Couples who bring thoughtful words to a fight release lower amounts of stress-related proteins, suggesting that rational communication between partners can ease the impact of marital conflict on the immune system.
More Tumor Current Events and Tumor News Articles
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Tumor by Joshua Hale Fialkov (Author), Noel Tuazon (Author) From the Harvey Award-nominated creative team of Elk's Run comes Tumor, the critically acclaimed sensation that was the first graphic novel to debut exclusively on the Kindle E-Book Reader! Tumor is the story of Frank Armstrong, a man at the boot heel of the world, barely scraping up a living as a private investigator in modern day Los Angeles. He finally lands a big case, finding the missing daughter of a drug kingpin, just as he's taken by the symptoms of a late-stage brain tumor. Memories blend with reality, as the missing girl case starts to seep into the memory of his own missing wife from 20 years prior. Now, with days, maybe even hours, left to live, he must save this girl, while the one thing he's relied on all of his life fails him - his mind! | |
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Seelenfresser by Tumor SPV. |
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Curveball: When Life Throws You a Brain Tumor by Liz Holzemer (Author) Life seemed idyllic for thirty-two-year-old Liz Holzemer. Wife of Major League Baseball pitcher Mark Holzemer, Liz was enjoying a successful career as a journalist when an MRI revealed a baseball-size brain tumor she soon found out was called meningioma. Told with clarity and unwavering humor, this book is an inspirational and informative account of one woman’s battle for her life. It shows how she emerged from this frightening diagnosis and two brain surgeries retaining her remarkable spirit of survival and renewed sense of purpose and hope. With practical information about meningioma and brain surgery, Curveball is a manual for people who face life-altering challenges and is also proof that one need not fight such battles alone. |
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Living with a Brain Tumor: Dr. Peter Black's Guide to Taking Control of Your Treatment by Peter Black (Author) Each year, 100,000 people in the United States are diagnosed with a brain tumor. With his new book, Dr. Peter Black fills a gap in the lay readership, providing an accessible medical resource for adult patients and their families. Dr. Black, who has operated on more than 3,000 patients with brain tumors, is uniquely qualified to discuss both clinical treatment of and research into brain tumors. This invaluable resource tells patients everything they need to know to understand and address their diagnosis, in a four-part structure: • “What is a Brain Tumor?" provides straightforward information about how brain tumors are diagnosed, the different types of tumors and how they develop, and where to go for treatment. • “Coping with Shock” addresses the emotional... |
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Neviens Tumors (Primary Contributor) |
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PIZZA TUMOR Funny Definition (Gotta See it to Believe it -TRUST ME, YOU'LL LAUGH) Ladies T-Shirt Pink Large by T-ShirtFrenzy The Design/Saying is printed on the front of this T-Shirt, we use the newest & best technology to print the design with great inks that are cured into the product. This new high tech way of producing garments is very fade resistant. WE DO NOT USE TRANSFERS. It is great, since you dont have that thick transfer feeling. The feel is very smooth and comfortable. T-ShirtFrenzy offers over 30,000 designs on tons of products to offer millions of variations. You can search our store for something for everyone on your gift list or shop for yourself (our personal favorite). Please contact us with questions. |
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Alternative Health & Herbs Remedies Skin Tumors (external), 1-Ounce Bottle (Pack of 2) by Alternative Health & Herbs Remedies Use externally for skin tumors, skin cancer, infection, and skin disorders. |
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Brain Tumors: Leaving the Garden of Eden--A Survival Guide to Diagnosis, Learning the Basics, Getting Organized, and Finding Your Medical Team by Paul M. Zeltzer (Author) A guidebook for the 150,000+ people/ year and families affected by brain tumors. This book will help you learn the basics about diagnosis, getting organized and finding your medical team. Included are chapters on all major types of brain tumors & metastases, glossary, medications, using the Internet to search for information, and getting a second opinion. "Brain Tumors:Leaving the Garden of Eden" is all about improving your odds by gathering information, & assessing your situation: What you need to do; what you need to know; what you can do now! |
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Mobile Starring: Keith Allen, Julie Graham, Michael Kitchen, Samantha Bond, Jamie Draven Directed By: Stuart Orme Conspiracy, betrayal, and revenge in the global telecom industry Someone is blowing up mobile-phone towers across England. Messages scrawled in blood-red paint at the scenes proclaim that mobile phones are the instruments of the devil. What’s more, a gunman -- or gunmen -- is shooting cell phone users in mid-conversation. Baffled police investigators scramble to avert public panic. In four interlocking parts, this tense drama peels back the layers of a terrorist conspiracy, gradually revealing the evil at its core. We follow three characters -- a disgraced telecom executive (Michael Kitchen, Foyle’s War), a bitter ex-soldier (Jamie Draven, Billy Elliot), and a disgruntled engineer (Neil Fitzmaurice, Going Off Big Time) -- all united by circumstance or collusion. In a style... |
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PetAlive C-Caps and DetoxPlus ComboPack by PetAlive The PetAlive ComboPack of C-Caps and DetoxPlus consists of multiple remedies that work well together to provide increased support for your pets condition. This ComboPack is effective for cancer support and systemic cleansing. The C-Caps strengthen immune system to prevent and treat cancer while the DetoxPlus cleanses the system and eliminates toxins from the body. |
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