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UCLA researchers outline the structure of the largest non-virus particle ever crystallized
November 27, 2007Researchers at UCLA, the California NanoSystems Institute, the David Geffen School of Medicine, and the Howard Hughes Medical Institute have modeled the structure of the largest cellular structure ever crystallized, suggesting ways to engineer the particles for drug delivery. The study, which focuses on newly engineered nanomaterial vaults for use as a drug therapy vehicle, will be published online this week in the open-access journal PLoS Biology.
Vaults are large barrel-shaped particles that are found in the cytoplasm of all mammalian cells, which may function in innate immunity. As naturally-occurring nano-scale capsules, vaults may be useful objects to engineer as therapeutic delivery vehicles. For the study, the team of researchers proposed an atomic structure for the thin outer shell of the vault.
"Our draft model is essentially an atomic-level vault with a completely unique structure-like a barrel with staves-it is unlike any other large structure found in nature," said Leonard H. Rome. "The outside of the vault structure is like an eggshell; a continuous protective barrier with no gaps."
The shell is made up of 96 identical protein chains, each of 873 amino acid residues, folded into 14 domains. Each chain forms an elongated stave of half the vault, as well as the cap of the barrel-like shell.
"These nano-structured vaults offer a human-friendly nano-container, like a molecular level C5A transport jet, with a cargo hold large enough to encompass a whole ribosome with their hundreds of proteins and nucleic acids, or enough drugs to control a cell," said David Eisenberg.
The construction of the draft atomic model lays the foundation for further studies of vaults and will guide projects of vault engineering with the intention towards targeted release of vault contents for drug delivery.
Public Library of Science
The shell is made up of 96 identical protein chains, each of 873 amino acid residues, folded into 14 domains. Each chain forms an elongated stave of half the vault, as well as the cap of the barrel-like shell.
"These nano-structured vaults offer a human-friendly nano-container, like a molecular level C5A transport jet, with a cargo hold large enough to encompass a whole ribosome with their hundreds of proteins and nucleic acids, or enough drugs to control a cell," said David Eisenberg.
The construction of the draft atomic model lays the foundation for further studies of vaults and will guide projects of vault engineering with the intention towards targeted release of vault contents for drug delivery.
Public Library of Science
Drug Delivery Current Events and Drug Delivery News RSSAn exquisite container
In campy old movies, Lucretia Borgia swans around emptying powder from her ring into wine glasses carelessly left unattended. The poison ring is usually a confection of gold filigree holding a cabochon or faceted gemstone that can be broken to empty the ring's contents. It is invariably enormous - so large it is rather odd nobody seems to notice it.
URI research couple's method targets cancerous tumors
Two University of Rhode Island associate professors, biophysicists Yana Reshetnyak and Oleg Andreev, have discovered a technology that can detect cancerous tumors and deliver treatment to them without the harming the healthy cells surrounding them, thereby significantly reducing side effects.
Stanford study recommends change in treating pulmonary embolisms
William Kuo, MD, was the on-call interventional radiologist one Friday night three years ago when he received a call from the intensive care unit at Stanford Hospital & Clinics.
Optimized inhaler mouthpiece design allows for more effective drug delivery
Researchers have developed an optimized mouthpiece design to aid efficient drug delivery to the lungs by reducing the amount of medication wasted as it passes through the mouthpiece of an aerosol inhaler.
Clemson bioengineer uses nanoparticles to target drugs
Clemson bioengineer Frank Alexis is designing new ways to target drugs and reduce the chances for side effects.
A step toward better brain implants using conducting polymer nanotubes
Brain implants that can more clearly record signals from surrounding neurons in rats have been created at the University of Michigan. The findings could eventually lead to more effective treatment of neurological disorders such as Parkinson's disease and paralysis.
Is inhaled insulin delivery still a possibility? Why has it been a commercial failure?
The commercial failure of Exubera® (Pfizer, New York, NY), the first inhaled insulin product to come to market, led other companies such as Eli Lilly-Alkermes to halt studies of similar drug delivery in development intended to compete for a share of the lucrative diabetes market.
New device could more effectively alleviate menstrual cramp pain
While most women experience minor pain during menstruation, for others, the pain can be severe enough to interfere with everyday activities and require medication.
Using magnetism to turn drugs on and off
Many medical conditions, such as chronic pain, cancer and diabetes, require medications that cannot be taken orally, but must be dosed intermittently, on an as-needed basis, over a long period of time.
Killing Cancer Like a Vampire Slayer
Like vampires, cancer tumors require an ample supply of blood to stay alive. Without fresh blood for sustenance, cancer cells shrivel up like raisins and die.
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Drug Delivery: Engineering Principles for Drug Therapy (Topics in Chemical Engineering) by W. Mark Saltzman (Author) Cornell Univ., New York. A reference providing researchers and professionals in advanced drug delivery systems or biomaterials, offering a working foundation in the principles governing the rate of drug transport, reaction and disappearance in physiological and pathological situations. DNLM: Drug delivery systems. |
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Drug Delivery Technology by Drug Delivery Tech Media Inc | |
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December Ends Starring: Josh Janowicz, Alex Thayer, Justin Matthews, Bill Buell, Jacob Reynolds Directed By: Lee Toland Krieger At just eighteen, Chris Conley's (Josh Janowicz, The Chumscrubber) life was shattered with the sudden death of his mom. His grieving, alcoholic dad unable to work, Chris turns to a last resort: running drugs for dealer Hayden. But Chris is unaware of the danger high-stakes drug dealing brings, or, as Hayden's habit consumes him, that he'll stop at nothing to keep his customers--and girlfriend Audrey--close. Audrey, desperate to escape the destructive existence she knows, turns to Chris for support. Their lives perilously intertwine...and fatefully collide in a time-stopping, explosive climax that leaves futures hanging delicately in the balance. DVD Features include: Director's Commentary; Deleted Scenes; Actor Rehearsal Footage. |
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Drug Delivery: Principles and Applications (Wiley Series in Drug Discovery and Development) by Binghe Wang (Author), Teruna J. Siahaan (Author), Richard A. Soltero (Author) An indispensable tool for those working at the front lines of new drug development Written for busy professionals at the forefront of new drug development, Drug Delivery gets readers quickly up to speed on both the principles and latest applications in the increasingly important field of drug delivery. Recent developments in such areas as combinatorial chemistry, proteomics, and genomics have revolutionized researchers' ability to rapidly identify and synthesize new pharmacological compounds. However, delivery-related properties remain a significant reason for clinical trial failures. Bringing together contributions by leading international experts, Drug Delivery covers the entire field in a systematic but concise way. It begins with an in-depth review of key... |
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Ansel's Pharmaceutical Dosage Forms And Drug Delivery Systems -9780781779340 by Lippincott Williams & Wilkins Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems -9780781779340 : Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems Pub Date: January 2010 Product Type: Print Author/s: Loyd V Allen Jr., PhD; Nicholas G Popovich PhD; Howard C Ansel PhD Long established as a core text for pharmaceutics courses, this book is the most comprehensive source on pharmaceutical dosage forms and drug delivery systems. Content coincides with the CAPE, APhA, and NAPLEX competencies.This edition includes updated drug information and has an increased focus on physical pharmacy. Coverage incorporates all new dosage forms on the market as well as those in the current US Pharmacopoeia-National Formulary. Includes updated photos. |
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Drug Delivery Douglas Edward (Primary Contributor) |
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Historic Print (M): Howard Williams, thirteen year old delivery boy for Shreveport, La. Drug Company. He wor by Olde Yankee Map and Photo Shoppe This is a museum quality, reproduction print on premium paper with archival/UV resistant inks. The framed work is single matted (ivory), under acrylic glass, with a hanging wire. Date: 1913 November. Subject: Notes: Title from NCLC caption card. Attribution to Hine based on provenance. In album: Street trades. Hine no. 3700. Format: Photographic prints. SOURCE: Library of Congress |
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Digital, Single Channel ID3 Iontophoresis Delivery System by Naimco Medical ontophoresis is the process by which drugs, usually dexamethasone and lidocaine, are introduced into a joint or small body part via electrical current. It is non-invasive, painless and it eliminates potential side effects and adverse reactions which can occur with medications delivered orally or by injection. |
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Administering Central I.V. Therapy (Video, Individual Version) [VHS] by Springhouse (Editor) |
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Drug Delivery and Targeting: For Pharmacists and Pharmaceutical Scientists by Anya M. Hillery (Editor), Andrew W. Lloyd (Editor), James Swarbrick (Editor) Saint Louis Univ., Madrid Campus, Spain. Provides a comprehensive introduction to the principles of advanced drug delivery and targeting, their current applications and potential future developments. Includes learning objectives, color illustrations and tables, chapter-end questions, and suggested reading. Softcover, hardcover not available. |
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