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UCLA researchers outline the structure of the largest non-virus particle ever crystallized
November 27, 2007Researchers at UCLA, the California NanoSystems Institute, the David Geffen School of Medicine, and the Howard Hughes Medical Institute have modeled the structure of the largest cellular structure ever crystallized, suggesting ways to engineer the particles for drug delivery. The study, which focuses on newly engineered nanomaterial vaults for use as a drug therapy vehicle, will be published online this week in the open-access journal PLoS Biology.
Vaults are large barrel-shaped particles that are found in the cytoplasm of all mammalian cells, which may function in innate immunity. As naturally-occurring nano-scale capsules, vaults may be useful objects to engineer as therapeutic delivery vehicles. For the study, the team of researchers proposed an atomic structure for the thin outer shell of the vault.
"Our draft model is essentially an atomic-level vault with a completely unique structure-like a barrel with staves-it is unlike any other large structure found in nature," said Leonard H. Rome. "The outside of the vault structure is like an eggshell; a continuous protective barrier with no gaps."
The shell is made up of 96 identical protein chains, each of 873 amino acid residues, folded into 14 domains. Each chain forms an elongated stave of half the vault, as well as the cap of the barrel-like shell.
"These nano-structured vaults offer a human-friendly nano-container, like a molecular level C5A transport jet, with a cargo hold large enough to encompass a whole ribosome with their hundreds of proteins and nucleic acids, or enough drugs to control a cell," said David Eisenberg.
The construction of the draft atomic model lays the foundation for further studies of vaults and will guide projects of vault engineering with the intention towards targeted release of vault contents for drug delivery.
Public Library of Science
The shell is made up of 96 identical protein chains, each of 873 amino acid residues, folded into 14 domains. Each chain forms an elongated stave of half the vault, as well as the cap of the barrel-like shell.
"These nano-structured vaults offer a human-friendly nano-container, like a molecular level C5A transport jet, with a cargo hold large enough to encompass a whole ribosome with their hundreds of proteins and nucleic acids, or enough drugs to control a cell," said David Eisenberg.
The construction of the draft atomic model lays the foundation for further studies of vaults and will guide projects of vault engineering with the intention towards targeted release of vault contents for drug delivery.
Public Library of Science
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Drug Delivery: Engineering Principles for Drug Therapy (Topics in Chemical Engineering) by W. Mark Saltzman (Author) Cornell Univ., New York. A reference providing researchers and professionals in advanced drug delivery systems or biomaterials, offering a working foundation in the principles governing the rate of drug transport, reaction and disappearance in physiological and pathological situations. DNLM: Drug delivery systems. |
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Nanoparticulate Drug Delivery Systems (Drugs and the Pharmaceutical Sciences) by Deepak Thassu (Editor), Michel Deleers (Editor), Yashwant Pathak (Editor) Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. This expertly written guide addresses the scientific methodologies, formulation, processing, applications, recent trends, and emerging technologies in the research of nanoparticulate drug delivery systems (NPDDS). It extensively covers applications of NPDDS, including lipid nanoparticles for dermal applications, nanocarriers for the treatment of restenosis, ocular, central nervous system, and gastrointestinal applications, and use as an adjuvant for vaccine development. |
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Nanoparticulate Drug Delivery Systems by Informa HealthCare Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. This expertly written guide addresses the scientific methodologies, formulation, processing, applications, recent trends, and emerging technologies in the research of nanoparticulate drug delivery systems (NPDDS). It extensively covers applications of NPDDS, including lipid nanoparticles for dermal applications, nanocarriers for the treatment of restenosis, ocular, central nervous system, and gastrointestinal applications, and use as an adjuvant for vaccine development. |
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Drug Delivery Systems (Methods in Molecular Biology) by Kewal K. Jain (Editor) The field of drug development and therapeutics can be overwhelmingly encyclopedic and vast. In "Drug Delivery Systems", Dr. Kewal Jain and a team of experts select the most important, cutting-edge technologies used in drug delivery systems taking into account significant drugs, new technologies such as nanoparticles, and therapeutic applications. The chapters present step-by-step laboratory protocols following the highly successful "Methods in Molecular Biology" series format, offering readily reproducible results vital for pharmaceutical physicians and scientists. Concise and systematic, "Drug Delivery Systems" is a powerful reference tool for the hundreds of companies developing drug delivery technologies all around the world. |
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Drug Delivery Technology by Drug Delivery Tech Media Inc | |
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New Product & Process Innovation (NPPI): Massively Parallel Microfabrication of Nanostructural Materials, and Nanotechnology Devices with Several Hi-tech ... Parallel Gene and Drug Delivery, and Others Starring: Professor Paul G. Ranky; PhD; NJIT; USA; with an in-depth technical discussion with Tim McKnight; PhD; Engineering Science and Technology Division; Oak Ridge National Laboratory; U.S. Department of Energy; Oak Ridge; TN; USA. Interviews and Edited by Professor Paul G. Ranky; PhD; NJIT; USA Directed By: PhD, NJIT, USA Professor Paul G. Ranky |
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Drug Delivery: Principles and Applications (Wiley Series in Drug Discovery and Development) by Binghe Wang (Author), Teruna J. Siahaan (Author), Richard A. Soltero (Author) An indispensable tool for those working at the front lines of new drug development Written for busy professionals at the forefront of new drug development, Drug Delivery gets readers quickly up to speed on both the principles and latest applications in the increasingly important field of drug delivery. Recent developments in such areas as combinatorial chemistry, proteomics, and genomics have revolutionized researchers' ability to rapidly identify and synthesize new pharmacological compounds. However, delivery-related properties remain a significant reason for clinical trial failures. Bringing together contributions by leading international experts, Drug Delivery covers the entire field in a systematic but concise way. It begins with an in-depth review of key... |
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Isoflavone Crème 4 oz. Jar - A natural solution for menopause and peri-menopause symptoms. Isoflavone Crème : provides an easy source of safe plant derived isoflavones: Genistein, Daidzein, Glycitein, Biochanin and Formononetin. (Soy only has two isoflavones: Genistein & Daidzein) Our Isoflavone crème is a bio-available herbal complex in a proprietary dermal delivery system. A Safe and Natural Alternative to Prescription Drugs! by Radiant Laboratories - Made in USA Isoflavone Crème : provides an easy source of safe plant derived isoflavones: Genistein, Daidzein, Glycitein, Biochanin and Formononetin. (Soy only has two isoflavones: Genistein & Daidzein) Our Isoflavone crème is a bio-available herbal complex in a proprietary dermal delivery system providing your body with natural phytoestrogens and phytoprogesterones. Most herbs taken orally are destroyed or rendered inactive by the digestion process. Topical application brings the desired ingredients directly to your body, bypassing the digestive track for faster, direct absorption. Isoflavone Crème : is a non-comedogenic cold processed moisturizing crème free of harmful chemicals like: DEA, TEA (triethanolamine), octyl palmitate, isopropyl palmitate, stearic acid, dimethicone, cyclomethicone,... |
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Historic Print (M): Howard Williams, thirteen year old delivery boy for Shreveport, La. Drug Company. He wor by Olde Yankee Map and Photo Shoppe This is a museum quality, reproduction print on premium paper with archival/UV resistant inks. The framed work is single matted (ivory), under acrylic glass, with a hanging wire. Date: 1913 November. Subject: Notes: Title from NCLC caption card. Attribution to Hine based on provenance. In album: Street trades. Hine no. 3700. Format: Photographic prints. SOURCE: Library of Congress |
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Intraocular Drug Delivery by Informa HealthCare This reference studies the most recent advances in the development of ocular drug delivery systems. Covering methods to treat or prevent ocular inflammation, retinal vascular disease, retinal degeneration, and proliferative eye disease, this source covers breakthroughs in the management of endophthalmitis, uveitis, diabetic macular edema, and age-related macular degeneration. |
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