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UCLA researchers outline the structure of the largest non-virus particle ever crystallized
November 27, 2007Researchers at UCLA, the California NanoSystems Institute, the David Geffen School of Medicine, and the Howard Hughes Medical Institute have modeled the structure of the largest cellular structure ever crystallized, suggesting ways to engineer the particles for drug delivery. The study, which focuses on newly engineered nanomaterial vaults for use as a drug therapy vehicle, will be published online this week in the open-access journal PLoS Biology.
Vaults are large barrel-shaped particles that are found in the cytoplasm of all mammalian cells, which may function in innate immunity. As naturally-occurring nano-scale capsules, vaults may be useful objects to engineer as therapeutic delivery vehicles. For the study, the team of researchers proposed an atomic structure for the thin outer shell of the vault.
"Our draft model is essentially an atomic-level vault with a completely unique structure-like a barrel with staves-it is unlike any other large structure found in nature," said Leonard H. Rome. "The outside of the vault structure is like an eggshell; a continuous protective barrier with no gaps."
The shell is made up of 96 identical protein chains, each of 873 amino acid residues, folded into 14 domains. Each chain forms an elongated stave of half the vault, as well as the cap of the barrel-like shell.
"These nano-structured vaults offer a human-friendly nano-container, like a molecular level C5A transport jet, with a cargo hold large enough to encompass a whole ribosome with their hundreds of proteins and nucleic acids, or enough drugs to control a cell," said David Eisenberg.
The construction of the draft atomic model lays the foundation for further studies of vaults and will guide projects of vault engineering with the intention towards targeted release of vault contents for drug delivery.
Public Library of Science
The shell is made up of 96 identical protein chains, each of 873 amino acid residues, folded into 14 domains. Each chain forms an elongated stave of half the vault, as well as the cap of the barrel-like shell.
"These nano-structured vaults offer a human-friendly nano-container, like a molecular level C5A transport jet, with a cargo hold large enough to encompass a whole ribosome with their hundreds of proteins and nucleic acids, or enough drugs to control a cell," said David Eisenberg.
The construction of the draft atomic model lays the foundation for further studies of vaults and will guide projects of vault engineering with the intention towards targeted release of vault contents for drug delivery.
Public Library of Science
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Researchers at Emory University and the Georgia Institute of Technology have developed microscopic polymer beads that can deliver an antioxidant enzyme made naturally by the body into the heart.
When seconds count: Interventional radiology treatment for pulmonary embolism saves lives
Catheter-directed therapy or catheter-directed thrombolysis-an interventional radiology treatment that uses targeted image-guided drug delivery with specially designed catheters to dissolve dangerous blood clots in the lungs-saves lives and should be considered a first-line treatment option for massive pulmonary embolism, note researchers in the November Journal of Vascular and Interventional Radiology.
An exquisite container
In campy old movies, Lucretia Borgia swans around emptying powder from her ring into wine glasses carelessly left unattended. The poison ring is usually a confection of gold filigree holding a cabochon or faceted gemstone that can be broken to empty the ring's contents. It is invariably enormous - so large it is rather odd nobody seems to notice it.
URI research couple's method targets cancerous tumors
Two University of Rhode Island associate professors, biophysicists Yana Reshetnyak and Oleg Andreev, have discovered a technology that can detect cancerous tumors and deliver treatment to them without the harming the healthy cells surrounding them, thereby significantly reducing side effects.
Stanford study recommends change in treating pulmonary embolisms
William Kuo, MD, was the on-call interventional radiologist one Friday night three years ago when he received a call from the intensive care unit at Stanford Hospital & Clinics.
Optimized inhaler mouthpiece design allows for more effective drug delivery
Researchers have developed an optimized mouthpiece design to aid efficient drug delivery to the lungs by reducing the amount of medication wasted as it passes through the mouthpiece of an aerosol inhaler.
Clemson bioengineer uses nanoparticles to target drugs
Clemson bioengineer Frank Alexis is designing new ways to target drugs and reduce the chances for side effects.
A step toward better brain implants using conducting polymer nanotubes
Brain implants that can more clearly record signals from surrounding neurons in rats have been created at the University of Michigan. The findings could eventually lead to more effective treatment of neurological disorders such as Parkinson's disease and paralysis.
Is inhaled insulin delivery still a possibility? Why has it been a commercial failure?
The commercial failure of Exubera® (Pfizer, New York, NY), the first inhaled insulin product to come to market, led other companies such as Eli Lilly-Alkermes to halt studies of similar drug delivery in development intended to compete for a share of the lucrative diabetes market.
New device could more effectively alleviate menstrual cramp pain
While most women experience minor pain during menstruation, for others, the pain can be severe enough to interfere with everyday activities and require medication.
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Wolfe Tory Medical Mad Nasal Drug Delivery Device W/ 3ml Syringe by Wolfe Tory Medical Wolfe Tory Medical MAD Nasal Drug Delivery Device w/ 3mL Syringe : Reliable atomization of topical solution across the nasal and oropharyngeal mucous membranes, no needlestick risk and disposable. You choose medication, exact dosage/ volume and delivery target. Fine mist-like spray. Targets desired mucosal region. Semipermeable soft plug absorbs runoff. Contoured tip designed for adult and childs nose. All MAD products are with luer lock connection, individually packaged clean and latex-free.Read the review |
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Historic Print (S): Howard Williams, thirteen year old delivery boy for Shreveport, La. Drug Company. He wor by Olde Yankee Map and Photo Shoppe This is a museum quality, reproduction print on premium paper with archival/UV resistant inks. The framed work is single matted (ivory), under acrylic glass, with a hanging wire. Date: 1913 November. Subject: Notes: Title from NCLC caption card. Attribution to Hine based on provenance. In album: Street trades. Hine no. 3700. Format: Photographic prints. SOURCE: Library of Congress |
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Digital, Single Channel ID3 Iontophoresis Delivery System by Naimco Medical ontophoresis is the process by which drugs, usually dexamethasone and lidocaine, are introduced into a joint or small body part via electrical current. It is non-invasive, painless and it eliminates potential side effects and adverse reactions which can occur with medications delivered orally or by injection. |
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