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Natural compound in broccoli could treat devastating genetic skin disorder
December 03, 2007Presented at American Society for Cell Biology annual meeting
Washington, D.C. -- The compound sulforaphane whose natural precursors are found at high levels in broccoli and other cruciferous vegetables has been hailed for its chemopreventive powers against cancer. Now sulforaphane has demonstrated new skills in treating a genetic skin blistering disorder called epidermolysis bullosa simplex (EBS), Pierre Coulombe and colleagues at the Johns Hopkins University School of Medicine in Baltimore report at the American Society for Cell Biology 47th Annual Meeting.
EBS is a rare but devastating inherited condition in which fluid-filled lesions called bullae appear at sites of frictional trauma to the skin. Unfortunately, treatment options for EBS are limited and palliative in nature. Much work remains to be done before sulforaphane can be tested clinically with EBS patients, but Coulombe notes that extracts from broccoli sprouts rich in sulforaphane have already been shown to be safe for use in human skin.
In EBS patients, the bottom layer of the epidermis, which is made of cells called keratinocytes, is unusually fragile and ruptures readily. Molecularly, most cases of EBS result from mutations in genes that produce the proteins keratin 5 (K5) and keratin 14 (K14). These proteins co-polymerize to form the intermediate filament cytoskeleton in basal keratinocytes. Since the discovery in 1991 that EBS is a keratin-based disease, more than 40 additional disorders affecting a broad range of tissues have been traced to defects in genes that encode intermediate filament proteins.
Coulombe and colleagues turned to sulforaphane in their search for a chemical activator that would induce the production of missing keratins in basal epidermis. There are 54 "conserved" keratin proteins in mammals -- meaning that evolution favored their survival. Many of these keratins are closely related in their genetic sequences and their properties and by their distribution within epithelial tissues. Coulombe reasoned that such a situation breeds "functional redundancy," meaning that the genetic loss of one keratin could be partially rescued by the overlapping functions of a keratin cousin.
Could this partial redundancy serve as the basis for therapy in EBS and related conditions? Coulombe was guided by prior evidence that partial redundancy was at work. In EBS patients, skin blisters heal without scarring, correlating with an induction in the expression of the protein K6, to which K5 is related, and of K17 and K16, to which K14 is related. In transgenic mouse models, these keratins are indeed partially redundant in their ability to provide structural support in skin keratinocytes.
Sulforaphane was originally identified by Johns Hopkins colleague, Paul Talalay, as the chemical entity in cruciferous vegetables responsible for its anti-cancer properties. As originally reported in the August 2007 issue of PNAS, the researchers found that exposing keratinocytes to sulforaphane caused the selective induction of keratins 16 and 17. Moving to an EBS mouse model with a K14 deficiency, they found that treatment with sulforaphane significantly reduced epidermal blistering while it was ineffective for a K5 deficient mouse.
American Society for Cell Biology
In EBS patients, the bottom layer of the epidermis, which is made of cells called keratinocytes, is unusually fragile and ruptures readily. Molecularly, most cases of EBS result from mutations in genes that produce the proteins keratin 5 (K5) and keratin 14 (K14). These proteins co-polymerize to form the intermediate filament cytoskeleton in basal keratinocytes. Since the discovery in 1991 that EBS is a keratin-based disease, more than 40 additional disorders affecting a broad range of tissues have been traced to defects in genes that encode intermediate filament proteins.
Coulombe and colleagues turned to sulforaphane in their search for a chemical activator that would induce the production of missing keratins in basal epidermis. There are 54 "conserved" keratin proteins in mammals -- meaning that evolution favored their survival. Many of these keratins are closely related in their genetic sequences and their properties and by their distribution within epithelial tissues. Coulombe reasoned that such a situation breeds "functional redundancy," meaning that the genetic loss of one keratin could be partially rescued by the overlapping functions of a keratin cousin.
Could this partial redundancy serve as the basis for therapy in EBS and related conditions? Coulombe was guided by prior evidence that partial redundancy was at work. In EBS patients, skin blisters heal without scarring, correlating with an induction in the expression of the protein K6, to which K5 is related, and of K17 and K16, to which K14 is related. In transgenic mouse models, these keratins are indeed partially redundant in their ability to provide structural support in skin keratinocytes.
Sulforaphane was originally identified by Johns Hopkins colleague, Paul Talalay, as the chemical entity in cruciferous vegetables responsible for its anti-cancer properties. As originally reported in the August 2007 issue of PNAS, the researchers found that exposing keratinocytes to sulforaphane caused the selective induction of keratins 16 and 17. Moving to an EBS mouse model with a K14 deficiency, they found that treatment with sulforaphane significantly reduced epidermal blistering while it was ineffective for a K5 deficient mouse.
American Society for Cell Biology
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Natural chemical found in broccoli helps combat skin blistering disease
Johns Hopkins scientists have found yet another reason why you should listen to your mother when she tells you to eat your vegetables. Sulforaphane, a chemical present at high levels in a precursor form in broccoli and related veggies (cauliflower, Brussels sprouts, etc.), helps prevent the severe blistering and skin breakage brought on by the rare and potentially fatal genetic disease epidermolysis bullosa simplex (EBS).
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Jarrow Formulations Jarrow Broccomax 250mg, 60 Capsules by Jarrow Formulations Cruciferous vegetables such as broccoli have been associated with antioxidant and cellular protection. BroccoMax® contains a standardized concentration of SGS (Sulforaphane Glucosinolate) extracted (without solvents)from broccoli seeds. SGS is metabolized to sulforaphane (isothiocyanate), which is a highly reactive antioxidant. In extensive studies, sulforaphane has been demonstrated to be a potent inducer of phase 2 detoxifying enzymes and protector of DNA. Each capsule of BroccoMax® contains 30 mg of sulforaphane glucosinolate, a concentration at least 20 times greater than that found in the full-grown broccoli plant.* |
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Broccoli Sprouts w/Sulphoraphane, 60 tabs - Available by PhysicianFormulas.com by Source Naturals A number of studies have shown that a diet rich in cruciferous vegetable such as broccoli, Brussels Sprouts, cabbage and cauliflower can be beneficial to your health. Researchers have isolated a key component of broccoli called sulforaphane, which may have many protective properties. Sulforaphane, an isothiocyanate is believed to stimulate enzymes in the body. Freshly germinated Broccoli sprouts contain 30 to 50 times the concentration of isothiocyanate as nature broccoli. Source Naturals Broccoli Sprouts Extract provides 2,000 mcg sulforphane daily equivalent to eating more than a pound of fresh broccoli. |
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The amazing power of broccoli.(sulforaphane glucosinolate)(Interview): An article from: Medical Update by Benjamin Franklin Literary & Medical Society, Inc. (Publisher) This digital document is an article from Medical Update, published by Benjamin Franklin Literary & Medical Society, Inc. on October 1, 2003. The length of the article is 1045 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: The amazing power of broccoli.(sulforaphane glucosinolate)(Interview) Publication: Medical Update (Newsletter) Date: October 1, 2003 Publisher: Benjamin Franklin Literary & Medical Society, Inc. Volume: 29 Issue: 4 Page: 1(2) Article Type: Interview Distributed by Thomson... | |
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Organic Broccoli Sprouting Seeds -5 Lbs- Organic- Edible Seed, Gardening, Hydroponics, Growing Salad Sprout & Food Storage- Brocolli Sprouts Contain Sulforaphane by Living Whole Foods 5 Lb. Nitro-Packed Can of Certified Organic Brocolli sprouting seed. Broccoli sprouts have just recently become popular after it was discovered that they abound with the amazing cancer-fighting phytochemical, sulforaphane. Research studies have shown that they contain 50 times more sulforpohane than fresh broccoli. What's more, they contain glucosinolates and isothiocyanates, substances that protect cells from becoming malignant, at 10-100 times greater levels than in fresh broccoli. In additon, they are sources of plant estrogens, similar to human estrogen, and so are helpful in cases of PMS, menopause, hot flashes and fibrocystic disease. Nutrient dense, they are rich sources of vitamins A, B, C, E and K, anti-oxidants, the minerals calcium, iron, magnesium, phosphorus, potassium and... |
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3 Bottles of Broccoli Sprout Capsules w/ Sulforaphane - Premium Brocolli Sprouts Herbal Supplements - 250 Mg. 30 Count Per Bottle by Living Whole Foods Handy Pantry Broccoli Sprouting Seeds are untreated with pesticides, herbicides, fungicides, chemical fertilizers or mercury, making them among the safest and most nutritious in the industry. Handy Pantry Broccoli Capsules are made from organically grown broccoli sprouts, carefully vacuum dried to preserve their sulforaphane content. Handy Pantry Broccoli Capsules are lab essayed and quality guaranteed. Help your customers prevent cancer for pennies per day. Sulforaphane is a compound that prevents cancer by "assisting the body to create an enzyme that prevents tumors from forming. The test showed sulforaphane from broccoli sprouts reduced cancer by 60-80 percent (Life Extension Dec. 1997). Further studies showed that "sulforaphane aided in shrinking tumors already present" (Dr. David... |
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Immunomodulatory activity of Sulforaphane, a naturally occurring isothiocyanate from broccoli (Brassica oleracea).: An article from: Phytomedicine: International ... Journal of Phytotherapy & Phytopharmacology by P. Thejass (Author), G. Kuttan (Author) This digital document is an article from Phytomedicine: International Journal of Phytotherapy & Phytopharmacology, published by Thomson Gale on August 1, 2007. The length of the article is 4925 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Immunomodulatory activity of Sulforaphane, a naturally occurring isothiocyanate from broccoli (Brassica oleracea). Author: P. Thejass Publication: Phytomedicine: International Journal of Phytotherapy & Phytopharmacology (Magazine/Journal) Date: August 1, 2007 Publisher: Thomson Gale Volume: 14 Issue: 7-8 Page:... | |
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SOURCE NATURALS, Broccoli Sprouts - 60 tabs by Source Naturals Researchers have isolated a key component of broccoli called sulforaphane, which is believed to stimulate enzymes in the body that play a role in detoxification. Broccoli Sprouts contain high levels of sulforaphane. Broccoli sprouts have been found to contain 10-100 times higher levels of sulforaphane then mature broccoli. Source Naturals Broccoli Sprouts Extract provides the daily equivalent of 4.5 oz of fresh broccoli. Source Naturals Broccoli Sprouts is suitable for vegetarians. |
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Organic Broccoli Sprouting Seeds -2 Lbs- Organic- Edible Seed, Gardening, Hydroponics, Growing Salad Sprout & Food Storage- Brocolli Sprouts Contain Sulforaphane by Living Whole Foods 2 Lb. Bag of Certified Organic Brocolli sprouting seed. Broccoli sprouts have just recently become popular after it was discovered that they abound with the amazing cancer-fighting phytochemical, sulforaphane. Research studies have shown that they contain 50 times more sulforpohane than fresh broccoli. What's more, they contain glucosinolates and isothiocyanates, substances that protect cells from becoming malignant, at 10-100 times greater levels than in fresh broccoli. In additon, they are sources of plant estrogens, similar to human estrogen, and so are helpful in cases of PMS, menopause, hot flashes and fibrocystic disease. Nutrient dense, they are rich sources of vitamins A, B, C, E and K, anti-oxidants, the minerals calcium, iron, magnesium, phosphorus, potassium and zinc. Also... |
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Organic Broccoli Sprouting Seeds - 16 Oz (1 Lbs)- Organic- Edible Seed, Gardening, Hydroponics, Growing Salad Sprout & Food Storage- Brocolli Sprouts Contain Sulforaphane by Wheatgrasskits.com These special sprouts provide a fresh and natural way to supplement your diet with sulforaphane, a phytochemical found in broccoli and related to tumor reduction according to John's Hopkins research. |
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