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Beating hospital yeast infection
December 06, 2007Increasing numbers of critically ill patients develop fungal or yeast infections, which are associated with high mortality. Now a review published in the online open access journal, Critical Care, compares treatments involving single-drug antifungal prophylaxis (SAP) or a multi-drug regimen of selective digestive tract decontamination (SDD) and suggests that both methods reduce yeast-related morbidity and mortality, but to different extents.
A team from Academic Medical Center Amsterdam, the Netherlands set out to compare the effectiveness of preventative antifungal therapies by trawling the medical databases. This yielded data from more than 5,500 patients enrolled in over thirty studies. The team compared data on SAP and SDD treatments in critically ill patients, detailing the incidence of yeast colonisation, infection, candidemia, and hospital mortality.
Both SDD and SAP reduced yeast-associated disease among the critically ill. The author's findings suggest that SDD is more effective than SAP for reducing yeast colonisation and infection, with the exception of candidemia. The latter responded best to SAP. Although both strategies decreased mortality attributable to yeast, SDD led to a significant reduction in all-cause in-hospital mortality.
"Systemic drugs may be advised as prophylaxis in patients with a high risk of developing Candida bloodstream infections, whereas SDD may be given to critically ill patients to prevent Candida colonisation and infection," the authors suggest.
Effective management of yeast infections is tricky, because diagnostic blood tests are only around 70 percent accurate, and it is hard to differentiate between normal yeast colonies and infection. Previous studies have investigated both SAP and SDD, but to date there has been no direct comparison between the two treatments. In 1995, yeast was reported to be the fourth most common intensive care unit-acquired infection in Europe. It could now be even more common, in lack of more recent data. Candida is also the fourth leading cause of all nosocomial blood stream infections in the USA, accounting for up to 11% of all infections.
BioMed Central
"Systemic drugs may be advised as prophylaxis in patients with a high risk of developing Candida bloodstream infections, whereas SDD may be given to critically ill patients to prevent Candida colonisation and infection," the authors suggest.
Effective management of yeast infections is tricky, because diagnostic blood tests are only around 70 percent accurate, and it is hard to differentiate between normal yeast colonies and infection. Previous studies have investigated both SAP and SDD, but to date there has been no direct comparison between the two treatments. In 1995, yeast was reported to be the fourth most common intensive care unit-acquired infection in Europe. It could now be even more common, in lack of more recent data. Candida is also the fourth leading cause of all nosocomial blood stream infections in the USA, accounting for up to 11% of all infections.
BioMed Central
Researchers at Case Western Reserve discover a new way the body fights fungal infection
A team of researchers led by Amy G. Hise, M.D., M.P.H., assistant professor at the Center for Global Health and Diseases, Case Western Reserve University School of Medicine, is the first to discover how the body fights off oral yeast infections caused by the most common human fungal pathogen, Candida.
Yeast missing sex genes undergo unexpected sexual reproduction
An emerging form of the pathogenic yeast Candida is able to complete a full sexual cycle in a test tube, even though it's missing the genes for reproduction.
Common misdiagnosis: most women believe they have a yeast infection when they don't
Most women who think they have a vaginal yeast infection are wrong and may be doing more harm than good in treating their problem, says a Saint Louis University researcher who presented her findings recently.
Pediatric HIV: Oral lesions are commonly associated with the disease
Across the globe, the presence of HIV is wide-spread. At the end of 2004, the United Nations HIV/AIDS program estimated that 2.5 million children under the age of 15 were affected worldwide.
New pathways for autoimmune treatment identified
A rare genetic defect that can trigger a host of diseases from type 1 diabetes to alopecia has helped explain the imbalance of immune regulator and killer cells in autoimmune disease.
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