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Protein protects brain against compound in lead poisoning, liver disease
December 07, 2007ANN ARBOR, Mich.---Scientists have discovered that a protein known as PEPT2 protects the brains of mice from a naturally occurring but potentially toxic compound present in lead poisoning and in a class of liver diseases that can cause serious neurological complications.
Scientists at the University of Michigan found that when dosed with the compound called 5-aminolevulinic acid (5-ALA), mice without the PEPT2 protein died sooner, had neuromuscular dysfunction, and had up to 30 times higher concentrations of the toxic compound in their cerebrospinal fluid than did mice with the PEPT2.
"The findings suggest that the PEPT2 protein could work the same way in humans," said David Smith, U-M professor and chair of pharmaceutical sciences. "If that is the case, then PEPT2 may have relevance as a secondary genetic modifier of conditions such as acute hepatic porphyrias and lead poisoning, and in drug transport at the blood-brain barrier.
"We are looking at how to use the body's own machinery to get the compounds to where we want them to go," Smith said.
Naturally occurring in the body, the acid is involved in forming a substance called heme, which is a component of hemoglobin as well as many important enzymes. If there is an accumulation or an overproduction of 5-ALA in the body, however, it can become toxic. High concentrations of 5-ALA are present in people who have lead poisoning or hepatic porphyrias.
University of Michigan
Lead Poisoning Current Events and Lead Poisoning News RSSChildren's blood lead levels linked to lower test scores
Exposure to lead in early childhood significantly contributes to lower performances on end-of-grade (EOG) reading tests among minority and low-income children, according to researchers at Duke University and North Carolina Central University.
Lead-Based Consumer Paint Remains a Global Public Health Threat
Although lead content in paint has been restricted in the United States since 1978, University of Cincinnati (UC) environmental health researchers say in major countries from three continents there is still widespread failure to acknowledge its danger and companies continue to sell consumer paints that contain dangerous levels of lead.
Ayurvedic medicines sold via Internet may contain lead, mercury or arsenic
An analysis of Ayurvedic medicines (based on a traditional medical system commonly used in India) purchased via the Internet found that one-fifth of these products contain levels of lead, mercury or arsenic that exceed acceptable standards, according to a study in the August 27 issue of JAMA.
Chronic lead poisoning from urban soils
Chronic lead poisoning, caused in part by the ingestion of contaminated dirt, affects hundreds of thousands more children in the United States than the acute lead poisoning associated with imported toys or jewelry. Could treating contaminated soil with water prevent this public health scourge?
In early childhood, continuous care by 1 doctor improves delivery of health screenings
Children examined by the same doctor during their first six months of life are more likely to receive appropriate preventive health screenings -- for lead poisoning, anemia and tuberculosis -- by age two.
Jefferson neuroscientists find early lead exposure impedes recovery from brain injury
Exposure to lead can hinder the brain's ability to recover from injury, a recent study in laboratory animals shows. The results have implications for the effects of environmental lead exposure on brain injuries such as stroke, say researchers at Jefferson Medical College, who led the work.
Improved NIST SRM aids lead poisoning detection
Lead in goat blood might not be on the top of your shopping list, but for U.S. medical personnel who each year perform more than 2 million human blood measurements, Standard Reference Material (SRM) 955c from the National Institute of Standards and Technology (NIST) can't be beat.
Research Explains How Lead Exposure Produces Learning Deficits
A study of young adult rats by researchers from the Johns Hopkins Bloomberg School of Public Health provides evidence that explains exactly how exposure to lead during brain development produces learning deficits.
Length of time to rid homes of lead hazards unacceptable, researchers say
The length of time it can take to rid homes of lead hazards is "unacceptable" according to researchers from Wake Forest University School of Medicine and colleagues in this month's American Journal of Public Health.
A silent pandemic: Industrial chemicals are impairing the brain development of children worldwide
Fetal and early childhood exposures to industrial chemicals in the environment can damage the developing brain and can lead to neurodevelopmental disorders (NDDs)-autism, attention deficit disorder (ADHD), and mental retardation.
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Toxic Truth: A Scientist, a Doctor, and the Battle over Lead by Lydia Denworth (Author) The first book to tell the incredible story of two men behind the bitter thirty-year fight to protect children from lead They didn't start out as environmental warriors. Clair Patterson was a geochemist focused on determining the age of the Earth. Herbert Needleman was a pediatrician treating inner-city children. But in the chemistry lab and the hospital ward, they met a common enemy: lead. It was literally everywhere-in gasoline and paint, of course, but also in water pipes and food cans, toothpaste tubes and toys, ceramics and cosmetics, jewelry and batteries. Though few people worried about it at the time, lead was also toxic. In Toxic Truth, journalist Lydia Denworth tells the little-known stories of these two men who were among the first to question the wisdom of filling the... |
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Getting the Lead Out: The Complete Resource for Preventing and Coping with Lead Poisoning by Irene Kessel (Author), John O'connor (Author), John T. O'Connor (Author) "Important. Urgent. Practical. Very, very useful."-Jonathan Kozol. Lead poisoning is one of the most common and preventable pediatric health problems in the United States. The prohibition of lead in paint in 1978, followed by the phasing out of lead in gasoline, have done a great deal to lower the average level of lead in children's blood in the last twenty-five years, but the threat to public health of this insidious poison is far from being eradicated. Every child is at risk. Getting the Lead Out explains the nature and sources of lead poisoning and discusses the basic measures for minimizing the associated risks and damage. It also explains the physical and emotional effects of lead poisoning, including problems with language-acquisition and other learning disabilities,... |
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Brush with Death: A Social History of Lead Poisoning by Christian Warren (Author) During the twentieth century, lead poisoning killed thousands of workers and children in the United States. Thousands who survived lead poisoning were left physically crippled or were robbed of mental faculties and years of life. In Brush with Death, social historian Christian Warren offers the first comprehensive history of lead poisoning in the United States. Focusing on lead paint and leaded gasoline, Warren distinguishes three primary modes of exposure -- occupational, pediatric, and environmental. This threefold perspective permits a nuanced exploration of the regulatory mechanisms, medical technologies, and epidemiological tools that arose in response to lead poisoning. Today, many children undergo aggressive "deleading" treatments when their blood-lead levels are well... |
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Lead Babies: Breaking the Cycle of Learning Disabilities, Declining IQ, ADHD, Behavior Problems, and Autism by Joanna Cerazy MEd (Author), Sandra Cottingham PhD (Author) This groundbreaking study reveals the continuing danger that lead contamination presents to health—particularly in the earliest stages of life. Disclosure about the lead content in house paint, gasoline, canned food, and tap water revolutionized the manufacturing of those products a generation ago, but lead-based products are still produced and pose a health hazard as lead remains in the environment years after its initial use. The deleterious effects of lead on early cognitive development are well documented, but the data in this reference regarding in utero lead transfer contains critical new information that shows the effects on infants and families. Week-by-week brain development in unborn and newborn children is demonstrated, explaining lead’s... |
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Lead Poisoning And Lead Absorption; The Symptoms, Pathology And Prevention by Thomas Morison Legge (Author) Many of the earliest books, particularly those dating back to the 1900s and before, are now extremely scarce and increasingly expensive. We are republishing these classic works in affordable, high quality, modern editions, using the original text and artwork. |
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The Doctor is In... Lead Poisoning: The Effects on Children's Health | |
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