Science Current Events | Science News | Brightsurf.com
 

Scientists find how bacteria in cows milk may cause Crohn's disease

December 11, 2007

Scientists at the University of Liverpool have found how a bacterium, known to cause illness in cattle, may cause Crohn's disease in humans.

Crohn's is a condition that affects one in 800 people in the UK and causes chronic intestinal inflammation, leading to pain, bleeding and diarrhoea.

The team found that a bacterium called Mycobacterium paratuberculosis releases a molecule that prevents a type of white blood cell from killing E.coli bacteria found in the body. E.coli is known to be present within Crohn's disease tissue in increased numbers.

It is thought that the Mycobacteria make their way into the body's system via cows' milk and other dairy products. In cattle it can cause an illness called Johne's disease - a wasting, diarrhoeal condition. Until now, however, it has been unclear how this bacterium could trigger intestinal inflammation in humans.

Professor Jon Rhodes, from the University's School of Clinical Sciences, explains: "Mycobacterium paratuberculosis has been found within Crohn's disease tissue but there has been much controversy concerning its role in the disease. We have now shown that these Mycobacteria release a complex molecule containing a sugar, called mannose. This molecule prevents a type of white blood cells, called macrophages, from killing internalised E.Coli."

Scientists have previously shown that people with Crohn's disease have increased numbers of a 'sticky' type of E.coli and weakened ability to fight off intestinal bacteria. The suppressive effect of the Mycobacterial molecule on this type of white blood cell suggests it is a likely mechanism for weakening the body's defence against the bacteria.

Professor Rhodes added: "We also found that this bacterium is a likely trigger for a circulating antibody protein (ASCA) that is found in about two thirds of patients with Crohn's disease, suggesting that these people may have been infected by the Mycobacterium."

The team is beginning clinical trials to assess whether an antibiotic combination can be used to target the bacteria contained in white blood cells as a possible treatment for Crohn's disease.

The research was funded by Core and the Medical Research Council and is published in Gastroenterology.

The University of Liverpool


Related Crohn’s Disease Current Events and Crohn’s Disease News Articles


Clinical studies show REMICADE reduces incidence of bowel surgeries in ulcerative colitis patients
Clinical data presented today at the annual meeting of the American College of Gastroenterology (ACG) show that REMICADE significantly reduces the incidence of colectomy surgeries for patients with moderately to severely active ulcerative colitis (UC).
More Crohn’s Disease Current Events and Crohn’s Disease News Articles

Controlling Crohn's Disease: The Natural Way

Controlling Crohn's Disease: The Natural Way
by Virginia Harper (Author), Tom Monte (Author)


Take Control Of Your Symptoms--Naturally!More than a million Americans suffer the pain, fevers, and bleeding of Crohn's disease, colitis, and other incurable inflammatory bowel disorders (IBDs), whose numbers are rising every year. While most patients are treated with harsh prescription drugs or invasive surgery, these merely mask or postpone the symptoms.All her life, author Virginia Harper had suffered from the debilitating effects of Crohn's disease. Even with heavy medication her symptoms persisted, and so she turned to a natural treatment regimen consisting of simple changes in diet and lifestyle. The results were truly remarkable. Within a year, she was not only pain-free, but symptom-free. Some twenty years later, Virginia's diarrhea, painful indigestion, cramps...

Crohn's and Colitis Diet Guide: Includes 175 Recipes

Crohn's and Colitis Diet Guide: Includes 175 Recipes
by Dr. Hillary Steinhart MD MSc FRCP(C) (Author), Julie Cepo BSc BASc RD (Author)


Diet is a huge priority for anyone living with Crohn's disease or ulcerative colitis. The authors provide crucial guidance for families, friends and caregivers too in helping to manage IBD (Inflammatory Bowel Disease) symptoms. This updated second edition, in a very informative and easy-to-understand manner, provides all the necessary guidelines regarding the specific foods that might cause problems, as well as delicious and nutritious recipes that can be enjoyed without compromising this difficult condition. The reliable answers from one of North America's top gastroenterology teams cover everything from the facts, causes and symptoms of IBD to the latest and most relevant information on drug therapies and surgical therapies -- in an easy-to-understand format. With its...

Go Your Crohn Way: A Gutsy Guide to Living with Crohn’s Disease

Go Your Crohn Way: A Gutsy Guide to Living with Crohn’s Disease
by Kathleen Nicholls (Author)


For Kathleen Nicholls, life with Crohn's disease has been a constant battle against her bowels. But life has also been about David Bowie, dancing, and laughter. Go Your Crohn Way follows the highs and lows of Kathleen's experiences, and is full of useful advice for maintaining self-confidence and positivity while navigating the world of work, relationships, and those conversations.Warm and inspiring, this book demonstrates how Crohn's can be life-changing, but not just for the worse. Kathleen gives advice and tips on adapting and thriving through Crohn's, including a specially created phrasebook, which proves that so long as you know how to ask for the nearest bathroom, globe-trotting is still firmly on the agenda.Full of fun and humour, Kathleen's journey through life with Crohn's...

Patient Heal Thyself

Patient Heal Thyself
by Jordan S. Rubin (Author)


Author Jordan Rubin, N.M.D., C.N.C., survived terminal Crohn’s disease. This story of his experience with alternative medicine and the cure that he eventually discovered in homeostatic soil organisms and the Maker’s Diet gives hope to everyone with an incurable disease. ‘No matter what health challenges plague you today, there is hope for an answer.’ So says Jordan Rubin in the introduction to this truly unique book. After all, he knows: Once at death’s door, he turned his life around. This book details how you too can make lasting changes in your life. In these pages, you will learn the health secrets that allowed our ancestors to live long, diseasefree lives. You will learn how to regain your health if you’ve lost it or how to maintain the excellent health that you currently...

Digestive Health with REAL Food: A Practical Guide to an Anti-Inflammatory, Nutrient Dense Diet for IBS & Other Digestive Issues

Digestive Health with REAL Food: A Practical Guide to an Anti-Inflammatory, Nutrient Dense Diet for IBS & Other Digestive Issues
by Aglaée Jacob M.S. R.D. (Author), Ray Sylvester (Editor)


Health begins in the gut. In addition to digestive disorders, many other health problems can stem from damage to your intestines, including migraines, skin problems, autoimmune conditions, and weight abnormalities, so tackling your digestion first is smart if you want to maximize your chances of obtaining optimal health. Beyond simply managing your symptoms, Digestive Health with REAL Food will teach you how to address the root causes of your digestive troubles to achieve optimal digestive and overall health. The information in Digestive Health with REAL Food will help you build your own optimal diet by identifying the best foods for your digestive system: ones that are easy to digest, anti-inflammatory, nutrient-dense, healing and low in irritants and allergens. The nutritional protocol...

Crohn's Disease and Ulcerative Colitis (Need to Know Library)

Crohn's Disease and Ulcerative Colitis (Need to Know Library)
by Sandra Giddens Dr (Author), Owen Giddens (Author), S Giddens (Author), O Giddens (Author)


Explains the causes and treatment of this medical condition

How to Cook for Crohn's and Colitis: More than 200 healthy, delicious recipes the whole family will love

How to Cook for Crohn's and Colitis: More than 200 healthy, delicious recipes the whole family will love
by Brenda Roscher (Author)


How to Cook for Crohn's and Colitis is a cookbook for anyone who suffers from inflammatory bowel disease (IBD, not to be confused with irritable bowel syndrome) or cooks for someone who has the disease. While there is no known cure for Crohn's disease or ulcerative colitis, their symptoms can be controlled in part by following the dietary guidelines of the American Dietetic Association.

Brenda Roscher provides sound nutritional advice and outlines the unique dietary needs of people with IBD, showing how to incorporate this information to make healthy choices about which foods to eat.

How to Cook for Crohn's and Colitis also contains informative sidebars on such topics as: Tips on Dining Out Organic vs. Non-Organic Foods How to...

Healing Foods: Cooking for Celiacs, Colitis, Crohn's and IBS

Healing Foods: Cooking for Celiacs, Colitis, Crohn's and IBS
by Elephant Publishing (Author)


This updated version of Healing Foods: Cooking for Celiacs, Colitis, Crohns and IBS, is a visually stunning and intelligently written cookbook. It is specifically designed to please and inspire all those who suffer from these debilitating intestinal diseases, as well as those who already live happier lives thanks to the Specific Carbohydrate Diet (TM). This book strictly adheres to the diet prescribed by Elaine Gottschall in her revolutionary book Breaking The Vicious Cycle. The Specific Carbohydrate Diet is a strict grain-free, lactose-free, and sucrose-free dietary regimen intended for those suffering from Crohn's disease, ulcerative colitis, celiac disease, diverticulitis, inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). The SCDiet has proven to be highly successful...

The Good Gut Guide

The Good Gut Guide
by Stephanie Zinser (Author), Prof. R. John Nicholls (Foreword)


The most comprehensive self-help book ever written for sufferers of poor intestinal health (10 million in the UK). Claire Rayner has praised it as 'a splendidly detailed book… it will be a life-saver for a great many people' and Prof. R. John Nicholls called it 'an invaluable book for anyone with a bowel or digestive problem.'One in five people in the UK suffer from lower gut disorders , which can be extremely painful and embarrassing. In The Good Gut Guide, Stephanie Zinser, a journalist and sufferer of ulcerative colitis herself, confronts these often ignored problems, with sections on: • Irritable Bowel Syndrome • Ulcerative Colitis • Crohn’s disease • Coeliac Disease • Diverticulosis • haemorrhoids • bowel cancer.This comprehensive book is not only an excellent...

Crohn's Disease Diet and Cookbook

Crohn's Disease Diet and Cookbook
by Sheen Publishing, U.S.A.


Wow! Crohn's Disease Diet and Cookbook is Free to borrow for all Amazon Prime Members AND absolutely Free to all KindleUnlimited subscribers! Also note that Crohn's Disease Diet and Cookbook is available on all Amazon Kindle devices, any Microsoft or Apple computers with the FREE Kindle applications and any Android devices, iPhones or iOS devices with the absolutely FREE Kindle app!

Crohn's Disease Diet and Cookbook (also known as Crohn’s Diet and Cookbook) is an educational and informational book on Crohn's disease with emphasis on diet and nutrition. Are you aware that just a few easy food allergy and Crohn's flare-up tests could help you with your digestive system problems and teach you what foods you can eat? And that you can discover if there are some foods you...

© 2017 BrightSurf.com