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Ashkenazi ovarian cancer patients with BRCA mutations live longer than those with normal gene
January 02, 2008Alexandria, VA-Israeli investigators have found that Ashkenazi Jewish women with ovarian cancer who have mutations in the BRCA1 or BRCA2 genes lived significantly longer than Ashkenazi Jewish ovarian cancer patients without these mutations. After up to nine years of follow-up, BRCA1/2 mutation carriers were 28 percent less likely to die from the disease, even though women with the BRCA mutations are significantly more likely to develop ovarian and breast cancers. The study is being published January 1 in the Journal of Clinical Oncology (JCO).
"These findings are encouraging news for BRCA mutation carriers," said Siegal Sadetzki, MD, MPH, head of the Cancer & Radiation Epidemiology Unit at the Gertner Institute, Chaim Sheba Medical Center in Tel Hashomer, Israel and the study's senior author. "It's possible that patients with these mutations respond better to chemotherapy - hopefully, once we learn more about the mechanisms of this response, tailoring individual treatment will further improve survival."
In one of the largest studies of this topic to date, the researchers from the National Israeli Study of Ovarian Cancer compared five-year survival between 213 Ashkenazi ovarian cancer patients with BRCA1/2 mutations ("carriers") and 392 Ashkenazi ovarian cancer patients without the mutations ("non-carriers").
After five years, 46 percent of the carriers were still alive, compared with 34.4 percent of the non-carriers. Median survival was 53.7 months for carriers and 37.9 months for non-carriers. The differences in survival were most pronounced for women diagnosed with more advanced disease (stage III or IV), with five-year survival rates of 38.1 percent for carriers and 24.5 percent for non-carriers. These findings persisted after controlling for other factors that influence ovarian cancer survival, such as patient age and some biological features of the tumor.
The researchers also analyzed ovarian cancer survival according to whether women had a BRCA1 or a BRCA2 mutation. Women with BRCA1 mutations lived a median of 45.1 months, and women with BRCA2 mutations lived a median of 52.5 months.
American Society of Clinical Oncology
Ovarian Cancer Current Events and Ovarian Cancer News RSSFDA approved leukemia drugs shows promise in ovarian cancer cells
The drug Sprycel, approved for use by the U.S. Food and Drug Administration in patients with chronic myeloid leukemia, significantly inhibited the growth and invasiveness of ovarian cancer cells and also promoted their death, a study by researchers with UCLA's Jonsson Comprehensive Cancer Center found.
American Dietetic Association Releases Updated Position Paper Promoting and Supporting Breastfeeding
The American Dietetic Association has released an updated position paper on breastfeeding that details health benefits for both infants and mothers and encourages promotion of breastfeeding whenever possible.
Metals could forge new cancer drug
Drugs made using unusual metals could form an effective treatment against colon and ovarian cancer, including cancerous cells that have developed immunity to other drugs, according to research at the University of Warwick and the University of Leeds.
Breast cancer patients with high risk gene diagnosed 6 years earlier than generation before
Women with a deleterious gene mutation are diagnosed with breast cancer six years earlier than relatives of the previous generation who also had the disease and/or ovarian cancer, according to new research from The University of Texas M. D. Anderson Cancer Center.
Cancer Predisposition From Gene Variant Shows Strong Gender Bias
Cancer predisposition resulting from the presence of a specific gene variant shows a strong gender bias, researchers at the University of Cincinnati (UC) have demonstrated.
Medications Effective in Reducing Risks for Breast Cancer Can Also Cause Serious Side Effects
Three drugs that reduce a woman's chance of getting breast cancer also have been shown to cause adverse effects, according to a new report from the Agency for Healthcare Research and Quality (AHRQ), U.S. Department of Health & Human Services.
Scientists from University of Hawaii at Manoa find genetic marker
A new genetic marker associated with ovarian cancer risk was recently discovered by an international research group, led by scientists from the Cancer Research Genetic Epidemiology Unit in the United Kingdom.
New treatment in sight for ovarian cancer
In the future, women with metastatic ovarian cancer could be treated with a radioactive substance that can seek and destroy tumour cells.
Young early stage ovarian cancer patients can preserve fertility
A new study finds that young women with early-stage ovarian cancer can preserve future fertility by keeping at least one ovary or the uterus without increasing the risk of dying from the disease.
Estrogen-Dependent Switch Tempers Killing Activity of Immune Cells
The sex hormone estrogen tempers the killing activity of a specific group of immune cells, the cytotoxic T cells (CTLs), which are known to attack tumor cells and cells infected by viruses.
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Beating Ovarian Cancer: How To Overcome The Odds And Reclaim Your Life by Chris Bledy (Author) A diagnosis of Ovarian Cancer does not have to be a death sentence. Recent advances in medicine have made this once incurable disease treatable and manageable. You can beat advanced and even recurring, ovarian cancer. Simple but significant lifestyle changes can produce big results when it comes to healing. |
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Ovarian Cancer Awareness "Unite to Fight" Wristband Adult Size by sci Ovarian Cancer Awareness "Unite To Fight" Wristband adult size |
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A Guide to Survivorship for Women with Ovarian Cancer (A Johns Hopkins Press Health Book) by F. J. Montz MD KM FACOG FACS (Author), Robert E. Bristow MD FACOG (Author), Paula J. Anastasia RN MN OCN (Assistant) This comprehensive guide to ovarian cancer offers a wealth of information to ease the physical, emotional, and psychic suffering of women with the disease. The authors -- two Johns Hopkins gynecologic oncologists and a gynecologic-oncology clinical nurse -- put particular emphasis on the concept of "survivorship," or living life well in the face of daunting uncertainties. They stress the importance of self-determination: the right of each patient to be informed, involved, and in control of her care. Up-to-date information on diagnosis and treatment, including surgery, chemotherapy, radiation, pain management, and alternative therapies, forms the core of the book. But the authors' immense clinical experience also means they understand what women worry about and care about, and... |
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Ovarian Cancer Awareness 8" Ribbon Car Magnet by sci Ovarian Cancer Awareness 8" Ribbon Car Magnet |
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L'Oréal Paris Color of Hope OCRF (Ovarian Cancer Research Fund) Fundraising Sterling Silver Pavé CZ Bracelet by Netaya Sterling beauty with an equally beautiful message. Its new, its exclusive and its absolutely beautiful. LOreal Paris is proud to present the Color of Hope Bracelet, a fundraising campaign, with 100% of all net profits ($5.00 per bracelet) benefiting The Ovarian Cancer Research Fund (OCRF). Whether viewed as a circle representing life, endurance, love or seen as an "O" for ovarian cancer, the bracelet is a simple way for women everywhere to visibly and tangibly help in the fight against one of the world's most deadly of women's cancers. The exclusive sterling silver Color of Hope bracelet features a rolo design chain with an "O" toggle clasp, adorned with pave cubic zirconias to give a beautiful brilliance. And to ensure that all women can adorn their wrists, the bracelet... |
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Ovarian Cancer Journeys: Survivors Share Their Stories To Help Others by Ayala Miron (Author) "All of the research has reinforced that ovarian cancer is not a silent disease as was once thought and as is shown quite eloquently in this collection of stories.... The value of this collection of stories is that it helps raise awareness about symptoms, need for patient persistence, and the importance of being treated by a gynecologic oncologist." Barbara A. Goff, MD Professor and Co-Director, Division of Gynecologic Oncology University of Washington School of Medicine Women of ages 17 to 78 join to tell their true stories. Find out about the lessons they have learned along their ovarian cancer journeys; from symptoms to diagnosis, trough treatments, and survival. Ovarian cancer facts: Occurs in 1 out of 57 women 89% have symptoms at the early stages... |
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100 Questions & Answers About Ovarian Cancer, Second Edition by Don S. Dizon (Author) Whether you're a newly diagnosed ovarian cancer patient, a survivor, or a friend or relative of either, this book offers help. Completely updated, the new second edition of 100 Questions & Answers About Ovarian Cancer gives you authoritative, practical answers to your questions about treatment options, post-treatment quality of life, sources of support, and much more. Written by a gynecologic oncologist and a gynecologic surgeon, with actual patient commentary, this book is an invaluable resource for anyone coping with the physical and emotional turmoil of this frightening disease. |
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Ovarian Cancer Awareness Teal Ribbon Crystal Heart Necklace by CharmingChick This is a beautiful new teal ribbon heart charm necklace that is the perfect way to show your support for Ovarian Cancer Awareness. The pendant measures about 5/8 of an inch tall and is made of genuine sterling silver. It has stunning teal Swarovski Crystal embedded in the front. Box chain measures about 16 inches long. This teal ribbon necklace would make a great gift or is a wonderful way to remember a loved one with Ovarian Cancer. |
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L'Oreal Paris Hope Necklace by Netaya The L'Oreal Paris Hope Necklace is a simple way for women everywhere to visibly and tangibly help in the fight against one of the most deadly women's cancers. The necklace was designed by 2008 Swarovski Award for Accessory Design recipient Philip Crangi and features a double eternity ring design of cubic zirconia set in sterling silver. One ring is worn for remembrance and one ring is worn as a symbol of hope for the future. The two eternity rings are free floating and suspended from an 18" rolo link chain. Each ring is comprised of 21 channel set, 2mm brilliant cubic zirconias. This necklace normally retails for $99 but is being offered for only $29.95 (plus $5.95 s&h) to support ongoing research to defeat this dreadful disease. Net profits (five dollars per sale) will benefit... |
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A Feather in My Wig: Ovarian Cancer Cured, Seventeen Years and Going Strong! by Barbara R. Van Billiard (Author), Theodore C. Barton (Contributor) The courageous story of one woman's successful battle against ovarian cancer. |
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