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Il-22 gene delivers the goods and decreases intestinal inflammation
January 03, 2008There are two major types of inflammatory bowel disease (IBD), Crohn disease (CD) and ulcerative colitis (UC). Conflicting reports have indicated that the soluble factor IL-22 can have both IBD promoting and IBD controlling effects. But now, Atsushi Mizoguchi and colleagues at Massachusetts General Hospital, Boston, have established that IL-22 ameliorates disease in a mouse model of UC.
Expression of IL-22 is much higher in the intestines of individuals with CD than UC. To investigate the role of IL-22 in IBD, the authors used a new microinjection-based strategy to deliver the gene that makes IL-22 to the walls of the intestine of mice who suffer from an intestinal disease that models UC. Delivery of the Il-22 gene ameliorated local intestinal inflammation through enhanced mucus production. Consistent with this, when the same strategy was used to deliver a gene that makes a protein that neutralizes IL-22, IL-22-binding protein, to the walls of the intestines of normal mice it enhanced chemical-induced intestinal inflammation. The authors therefore suggest that individuals with UC might benefit from local delivery of the IL-22 gene to their intestines.
Journal of Clinical Investigation
Intestinal Inflammation Current Events and Intestinal Inflammation News RSSLargest gene study of childhood IBD identifies 5 new genes
In the largest, most comprehensive genetic analysis of childhood-onset inflammatory bowel disease (IBD), an international research team has identified five new gene regions, including one involved in a biological pathway that helps drive the painful inflammation of the digestive tract that characterizes the disease.
The bowels of infection
Current research suggests that latent cytomegalovirus (CMV) infection may exacerbate inflammatory bowel disease (IBD). The related report by Onyeagocha et al, "Latent cytomegalovirus infection exacerbates experimental colitis," appears in the November 2009 issue of The American Journal of Pathology.
UCLA cancer researchers first to link intestinal inflammation with systemic chromosome damage
UCLA scientists have linked for the first time intestinal inflammation with systemic chromosome damage in mice, a finding that may lead to the early identification and treatment of human inflammatory disorders.
Packard/Stanford study suggests two causes for bowel disease in infants
New research from Lucile Packard Children's Hospital and the Stanford University School of Medicine is helping physicians unravel the cause of a deadly and mysterious bowel disease that strikes medically fragile newborn babies.
Cholesterol modulates sorting of CEA -- implications for inflammatory bowel disease
In polarized Caco-2 cells, cholesterol was depleted by a combination of synthesis inhibition and plasma membrane extraction with complexing agents.
Scientists find how bacteria in cows milk may cause Crohn's disease
Scientists at the University of Liverpool have found how a bacterium, known to cause illness in cattle, may cause Crohn's disease in humans.
Cornell scientists link E. coli bacteria to Crohn's disease
A team of Cornell University scientists from the College of Veterinary Medicine, Weill Cornell Medical College and the College of Agriculture and Life Sciences have discovered that a novel group of E. coli bacteria - containing genes similar to those described in uropathogenic and avian pathogenic E. coli and enteropathogenic bacteria such as salmonella, cholera, bubonic plague - is associated with intestinal inflammation in patients with Crohn's disease.
Identification of genetic risk factor for coeliac disease promises improved treatment
An international research consortium investigating the genetic causes of intestinal inflammatory conditions has identified a new genetic risk factor for coeliac disease.
Researchers identify molecular basis of inflammatory bowel disease
Inflammatory bowel diseases, such as Crohn's disease and Ulcerative Colitis, severely impair the lives of more than four million people worldwide. The development of effective therapies against these diseases requires an understanding of their underlying molecular mechanisms. Researchers from the Universities of Cologne and Mainz in Germany, the Mouse Biology Unit of the European Molecular Biology Laboratory (EMBL) in Italy and their collaborators, have now deciphered a molecular signal that triggers chronic intestinal inflammation.
Scientists find major susceptibility gene for Crohn's disease
A consortium of American and Canadian researchers report in Science Express, a rapid online publication by the journal Science, the discovery of a new genetic link to Crohn's disease.
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Intestinal Inflammation and Colorectal Cancer (Falk Symposium) by C. Gasche (Editor), M. Gassull (Editor), J.M. Herrerías Gutiérrez (Editor), E. Monteiro (Editor) This book is the proceedings of the Falk Symposium 158, on âIntestinal Inflammation and Colorectal Cancerâ, held in Seville, Spain, on 23--24 March 2007. The past 15 years have brought significant progress in the molecular understanding of colon carcinogenesis and tumour progression. This knowledge originated primarily from familial cancer syndromes, extended to sporadic tumours and fuelled the development of target-specific drugs. In contrast, the functional relationship between inflammation and the origin of cancer is not new. The German pathologist Rudolf L.K. Virchow had hypothesized this some time ago (âDie krankhaften Geschwuelsteâ,1863--7). Highlighted by over 400 scientific reports, the role model of inflammation-driven carcinogenesis is colorectal cancer in... |
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Balanceuticals HernEase, 500 mg Dietary Supplement Capsules, 60-Count Bottle by Balanceuticals Dietary supplement. 100% Natural. Made under Supervision by China Academy of Traditional Chinese Medicine. Made of extracts from lindera, costus root, fennel seed, blue citrus peel, areca nut, chinaberry, evodia, and citrus seed, this time-honored formula is used in Chinese medicine for its Qi (vitalenergy) building, stomach and intestine nurturing, distention relieving, abdominal discomfort soothing, diaphragm strengthening, internal organ dislocation correcting, and blood circulation promoting properties to maintain healthy relationship among body organs and their proper functions. (This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.) |
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Intestinal Inflammation (Colitis, Enteritis, Crohn's Disease): Treatment & Therapy Index of New Information by American Health Research Institute (Author) | |
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Mechanisms of Intestinal Inflammation: Implications for Therapeutic Intervention in IBD (Falk Symposium) by R. Duchmann (Editor), R.S. Blumberg (Editor), M.F. Neurath (Editor), J. Schölmerich (Editor), W. Strober (Editor), M. Zeitz (Editor) In recent years considerable progress has been achieved in regard to our understanding of the induction and modulation of the immune response in the intestinal mucosa. It is clear that this mucosal immune reaction is predominantly steered by certain T-cell populations, which are characterized by their cytokine secretion profile. Less well known are the conditions under which the uptake and processing of a specific antigen leads to a certain immune response, whether it be protective, tolerant or inflammatory. However, here again distinct progress has been made in our understanding. Equally significant for immune regulation in the gut appears to be so-called innate immunity. Every shift of equilibrium in the highly regulated mucosal immune reaction is accompanied by an... |
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Glial cells in the enteric nervous system: Plasticity of glial cells in the enteric nervous system during intestinal inflammation by Sebastian Hoff (Author) Enteric glial cell (EGC) markers were thoroughly characterized in the human enteric nervous system (ENS) and EGC numbers were compared in man and guinea pig. As a result, the Sox8/9/10 antibody was shown to be an excellent investigative tool to assess EGC in the ENS and the glia index was identified as the most robust quantitative descriptor within a species. Subsequently, this Sox8/9/10 was used in Crohn´s disease specimens to quantify enteric glia. In a parallel approach, interactions of EGC and the intestinal epithelial barrier were analyzed. Results from these experiments indicate a protective effect of EGCs on the intestinal epithelial barrier in intestinal inflammation. The observed expression of GDNF, NGF, NT-3 and their receptors by EGC points to promising targets... |
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Effects of Cytokines & Intestinal Inflammation on Enteric Neuronal Behavior & Neurotransmitter Release (Acta Biomedica Lovaniensia, 268) by Annemarie Kelles (Author) |
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Myrrh - Helps with sore throats and infected gums, soothes stomach and intestinal inflammation, 2 oz., (Health Herb) by HerbalLoveShop Myrrh is an antiseptic, antibiotic, antimicrobial, expectorant, and astringent. MYRRH (Commiphora molmol) A cleansing agent which counters toxins in the body. It is often used as a main ingredient in mouthwashes and gargles to help with sore throats, infected gums, pyorrhea, and halitosis. It is beneficial for Candida albicans (thrush) and for athlete's foot. Other uses: for leg ulcers and other sores; as a tonic and stimulant for bronchial and lung diseases; as a natural anesthetic; to cleanse the stomach and colon; as an antiseptic poultice on boils, sores and other wounds. Myrrh is a cleansing and healing herb similar to echinacea. Helps with sore throats and infected gums, soothes stomach and intestinal inflammation, stimulates circulation, can be used externally for skin problems. |
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Intestinal Inflammation (Colitis, Enteritis, Crohn's Disease): Treatment & Therapy : Index of New Information by American Health Research Institute (Author) | |
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An inquiry into the anatomical characters of infantile follicular inflammation of the gastro-intestinal mucous membrane; and into its probable identity with cholera infantum. by William Edmonds (1793-1853). HORNER (Author) | |
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Alfa Vitamins Acidophilus Probiotics 300 mg 60 caps Fortify Intestinal Flora by Alfa Vitamins There are over 400 species of microorganisms in the human digestive tract. The body depends on beneficial bacteria to manufacture B vitamins as well as to produce lactase and other antibacterial substances. Probiotics are live microbial organisms that are naturally present in the digestive tract and vagina. Probiotics are considered beneficial and are sometimes referred to as friendly bacteria. Some of the ways they are thought to promote health include suppressing the growth of potentially harmful bacteria, improving immune function, enhancing the protective barrier of the digestive tract, and helping to produce vitamin K. Acidophilus Probiotics is a supplement of microbial origin that favors the balance of the intestinal flora and can reintroduce beneficial bacteria into the system. It... |
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