 |
|
How actin networks are actin'
January 03, 2008Dynamic networks of growing actin filaments are critical for many cellular processes, including cell migration, intracellular transport, and the recovery of proteins from the cell surface. In this week's issue of the open-access journal PLoS Biology, researchers at Washington University in St. Louis shed light on how multiple proteins cooperate to regulate the assembly of such actin networks.
A central player in generating actin networks is the Arp2/3 complex. In most cells, there are multiple proteins that can regulate the function of the Arp2/3 complex, although how the activities of these proteins are coordinated in the cell to generate the appropriate network of actin filaments in a complex, multi-step process remains unclear. To better understand how multiple Arp2/3 regulatory proteins are coordinated in the cell, Brian Galletta, Dennis Chuang, and John Cooper used a combination of live-cell imaging, computer-aided particle tracking, and quantitative motion analysis to determine how disruption of the function of each of these regulatory proteins, individually and its combination, altered the movement of actin patches in bakers yeast.
These studies have revealed that while Arp2/3 regulatory proteins sometimes play overlapping roles in this process, they often play unique roles. The molecular machinery contained in actin patches can be found throughout nature. Therefore, Brian Galleta says that, "these studies should shed light on how actin networks are regulated in human cells during normal cell function and allow for a better understanding of how actin misregulation might contribute to the progression of disease processes including cancer, inflammation, and infection."
Public Library of Science
Public Library of Science
Actin Current Events and Actin News RSSHow HIV cripples immune cells
In order to be able to ward off disease pathogens, immune cells must be mobile and be able to establish contact with each other. The working group around Professor Dr. Oliver Fackler in the Virology Department of the Hygiene Institute of the Heidelberg University Hospital has discovered a mechanism in an animal model revealing how HIV, the AIDS pathogen, cripples immune cells: Cell mobility is inhibited by the HIV Nef protein.
Study shows how disruption of spectrin-actin network causes lens cells in the eye to lose shape
A network of proteins underlying the plasma membrane keeps epithelial cells in shape and maintains their orderly hexagonal packing in the mouse lens, say Nowak et al.
Dividing cells 'feel' their way out of warp
Every moment, millions of a body's cells flawlessly divvy up their genes and pinch perfectly in half to form two identical progeny for the replenishment of tissues and organs - even as they collide, get stuck, and squeeze through infinitesimally small spaces that distort their shapes.
UCF scientists control living cells with light; advances could enhance stem cells' power
University of Central Florida researchers have shown for the first time that light energy can gently guide and change the orientation of living cells within lab cultures.
St. Jude scientists discover a new mechanism controlling neuronal migration
The molecular machinery that helps brain cells migrate to their correct place in the developing brain has been identified by scientists at St. Jude Children's Research Hospital.
Building memories with actin
Memories aren't made of actin filaments. But their assembly is crucial for long-term potentiation (LTP), an increase in synapse sensitivity that researchers think helps to lay down memories.
Intestinal cells surprisingly active in pursuit of nutrition and defense
Every cell lining the small intestine bristles with thousands of tightly packed microvilli that project into the gut lumen, forming a brush border that absorbs nutrients and protects the body from intestinal bacteria.
Fate in fly sensory organ precursor cells could explain human immune disorder
Notch signaling helps determine the fate of a number of different cell types in a variety of organisms, including humans. In an article that appears in the current issue of Nature Cell Biology, researchers at Baylor College of Medicine report that a new finding about the Notch signaling pathway in sensory organ precursor cells in the fruit fly could explain the mystery behind an immunological disorder called Wiskott-Aldrich syndrome.
Advance in understanding cellulose synthesis
Cellulose is a fibrous molecule that makes up plant cell walls, gives plants shape and form and is a target of renewable, plant-based biofuels research.
Muscle atrophy through thick but not thin
During desperate times, such as fasting, or muscle wasting that afflicts cancer or AIDS patients, the body cannibalizes itself, atrophying and breaking down skeletal muscle proteins to liberate amino acids.
More Actin Current Events and Actin News Articles
 |
Actin a Ass (Feat. Da Heathin) Skip Dog (Primary Contributor) |
 |
Actin (Protein Profile (Unnumbered).) by Peter Sheterline (Author), Jon Clayton (Author), John Sparrow (Author) Actins are highly conserved proteins found in virtually all eukaryotic cells. They have prolific roles in cell motility, from the contraction of striated muscle to the movement of organelles within cells, and are known to interact with a diverse number of proteins. This up-to-date edition gives a comprehensive account of actin sequence, mutation, and structure as well as providing insight into ligand-binding sites and drug and toxin binding. |
 |
Actin' Naturally by Johnny Russell Grand Ole Opry star Johnny Russell first gained notice as a songwriter in 1960 after Jim Reeves recorded his "In a Mansion Stands My Love" (flip side to "He'll Have to Go") and came into his own after Buck Owens's 1963 hit with his "Act Naturally" (later recorded by the Beatles). Russell's own hit singles (most notably 1973's "Rednecks, White Socks and Blue Ribbon Beer") earned him Opry membership and later, regular TNN appearances. While he avoids remaking his own hits on this CD, the songs here are all his, with cameos by Dolly Parton, Buck Owens, Marty Stuart, Bobby Bare, Crystal Gayle, Earl Scruggs, Sonny Osborne, and sidemen who provide strong bluegrass accompaniment throughout. Russell revisits "Act Naturally" with Owens, Scruggs, and Stuart. Parton joins him to reprise "Making... |
 |
Rsab8: Ridin' Slab and Actin Bad Starring: Various Artists Included are the Sea Awards with live performances by Lil Flip, Trae & ABN, and Tum-Tum. Featured artists include Trae, Billy Cook, Lil Flip, Tum Tum, Jody Breeze, Magno, Kottonmouth, DJ Bull & Da Ryno, Gangsta Boo, Z-Ro, Chalie Boy, Wine-O, Fat Pat, Jib |
 |
Ultra Inflam Actin - 60 - Veg Caps by Nature's Plus Description: Nature's Plus Ultra INFLAM-Actin is a technologically advanced combination of anti-inflammatory herbs and nutrients, to include a patented, standardized Boswellia extract, 5-Loxin, and the proprietary blend, AlleviZyme. Ultra INFLAM-Actin -SUPPLEMENT FACTS Serving Size 2 Capsules Amount % DV Calcium (as sulfate from SierrasilTM) ........................................................................................10 mg 1 Iron (as potassium-iron sulfate from SierrasilTM) ** ... |
|
De-Sta-Co 6004 450lb Cap Ergo Handle Straight-line Actin Clamp by De-Sta-Co Straight-Line Action Clamps Clamp Type: Straight Line Manufacturer's Part Number: 6004 Holding Capacity: 450 Plunger Travel: 1.50 In. Handle Type: Ergonomic Material: Carbon Steel | |
 |
Nehemiah's Actin' Up Also With: Mary-Ellis Bunim (Producer), Jonathan Murray (Producer) |
 |
Acting Out Musical Gold Yellow Chicken Dance Skirt by Acting Out Musical Chicken Dance Skirt by Acting Out Tail feathers will be shaking with this Musical Chicken Dance Skirt by Acting Out. The infamous "party" favorite polka song is sure to have all your little chicks dancing and smiling. This Musical Chicken Dance Skirt by Acting Out is three layers and lined with itch free satin. Yellow and hot pink marabou trim the bottom skirt edge. Fits ages three to six. Includes new adjustable waistband. Three AAA batteries included. Ages 3 and Up By Acting Out |
 |
30054 5-ton Single Actin (277-RC-50) Category: Hydraulic Cylinders by Enerpac Item #: 277-RC-50. Baked enamel finish for increased corrosion resistance Collar threads, plunger threads and base mounting holes enable easy fixturing (on most models) CR400 Coupler and Dust Cap Included on All Models High strength alloy steel for durability Capacity Wt. = 5 tons [Max]Stroke Length = 0.630 inOperating Pressure = 10000.0 psi [Max]Cylinder Effective Area = 0.99 sq. in.Oil Cap. = 0.62 cu inCollapsed Height = 1.63 inExtended Height = 2 1/4 inBore Diameter = 1.130 inPlunger Diameter = 1 inActivating Fluid = OilIncludes = CR-400 Coupler, Dust CapType = Spring ReturnWt. = 2.20 lb |
 |
Guess IM Actin Like A Child Bobby Smith (Primary Contributor) |
| © 2009 BrightSurf.com |