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Jefferson scientists studying the effects of high-dose vitamin C on non-Hodgkin lymphoma patients
January 03, 2008Scientists at Thomas Jefferson University Hospital and Jefferson's Kimmel Cancer Center have received approval for a first-of-its kind study on the effect high dose vitamin C has on non-Hodgkin lymphoma patients. Researchers from the Jefferson-Myrna Brind Center of Integrative Medicine and Kimmel Cancer Center in conjunction with the National Institutes of Health will study whether high doses of vitamin C can slow the progression of the deadly disease.
"This is a very unique study for a set of patients who have really run out of options," said Daniel Monti, M.D., director of the Myrna Brind Center of Integrative Medicine, and primary investigator of the study. "Vitamin C administered intravenously has shown great promise in the laboratory and there has been some anecdotal data in cancer patients, but no one has really ever run a detailed study on humans. Vitamin C doesn't cost much and is very low in toxicity, making it a particularly desirable agent for further study."
Recent research conducted by the NIH collaborators of this study has shown that when given in sufficient amounts intravenously, vitamin C converts to hydrogen peroxide. When applied to certain non-Hodgkin lymphoma cells in the laboratory, the converted hydrogen peroxide kills them while leaving the surrounding healthy cells intact.
"Previous human studies have been flawed because the vitamin C was given orally versus intravenously," said Monti. "The problem with that is the oral route tightly limits the amount of vitamin C that can get into the bloodstream. When vitamin C is given intravenously you can get up to 70 times more of the vitamin into the blood versus the same dose given orally. It is these high blood levels that are required to get the mechanism of action, vitamin C converting to hydrogen peroxide around the cancer cells, to occur. Although other cancers could be a contender for this intervention, the preliminary data on non-Hodgkin lymphoma cells is why we decided to start with this disease."
The study will begin with 20 non-Hodgkin lymphoma patients who have failed standard therapy. Each study participant will be given varied intravenous doses of vitamin C three times a week. The patients will be evaluated and monitored for progression of their disease. The study's goals are to show diminished progression of the disease in participating patients.
"As leaders in the field of integrative medicine, Jefferson is always seeking new and innovative therapies for our patients," concluded Monti. "We want to look in every corner for solutions. This study is a unique collaboration of several clinical and research specialists. If this study yields positive data we will do further studies to expand the availability of this intriguing therapy."
Thomas Jefferson University
"Previous human studies have been flawed because the vitamin C was given orally versus intravenously," said Monti. "The problem with that is the oral route tightly limits the amount of vitamin C that can get into the bloodstream. When vitamin C is given intravenously you can get up to 70 times more of the vitamin into the blood versus the same dose given orally. It is these high blood levels that are required to get the mechanism of action, vitamin C converting to hydrogen peroxide around the cancer cells, to occur. Although other cancers could be a contender for this intervention, the preliminary data on non-Hodgkin lymphoma cells is why we decided to start with this disease."
The study will begin with 20 non-Hodgkin lymphoma patients who have failed standard therapy. Each study participant will be given varied intravenous doses of vitamin C three times a week. The patients will be evaluated and monitored for progression of their disease. The study's goals are to show diminished progression of the disease in participating patients.
"As leaders in the field of integrative medicine, Jefferson is always seeking new and innovative therapies for our patients," concluded Monti. "We want to look in every corner for solutions. This study is a unique collaboration of several clinical and research specialists. If this study yields positive data we will do further studies to expand the availability of this intriguing therapy."
Thomas Jefferson University
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Nature Made Vitamin C, 1000 mg, Premium Tablets, Value Size, 300 premium tablets by Nature Made USP-Verified Dietary Supplement. Recommended by pharmacists. Antioxidant - Helps boost the immune system. Vitamin C helps neutralize free radicals and helps iron get absorbed in the body. UPS has tested and verified ingredients, potency and manufacturing process. USP sets official standards for dietary supplements. No artificial colors. No artificial flavors. No preservatives. No chemical solvents, yeast or gluten. (These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease). |
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Now Foods Vitamin C-1000 W/ Rose Hips- Sustained Release, 250 Tablets by NOW In today's hectic lifestyle, our bodies are constantly depleting the nutrients we rely on to help us perform at our pinnacle. Perfect for the active professional, athlete or individual with sensitive systems, NOW Vitamin C 1000 mg Sustained Release delivers gradual amounts of this powerful antioxidant rendering consistent cell protection and free radical fighting throughout our busy days. * Picture may be of different size or flavor |
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Vitamin C W/Rose Hips 1,000 mg 250 Tabs by Swanson Premium Brand A high-potency source of vitamin C, fortified with rose hips! One of nature's richest sources of vitamin C, rose hips contain bioflavonoids that promote the vitamin's absorption and enhance its antioxidant potency. Each tablet supplies 1000 mg of vitamin C with 100 mg of rose hips. |
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Now Foods C-1000 Capsules, 250 Capsules by NOW Vitamin C is perhaps the most popular vitamin known to man. It is consumed in a supplemental form by millions of people across the world for its antioxidant properties, which are well-documented in medical research. C-1000 provides a potent dosage of this key vitamin and is blended with Bioflavonoids, which help promote the function of Vitamin C,. * Picture may be of different size or flavor |
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Nature Made Vitamin C Supplement Caplets, 500 mg, 100-Count Tablets (Pack of 3) by Nature Made Nature Made Vitamin C 500mg 3-pack/100-count |
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Nature Made Vitamin C Supplement Tablets, 1000 mg, 100-Count Bottles (Pack of 3) by Nature Made Supplement. USP verified. Recommended by pharmacists. Antioxidant helps boost the immune system. Vitamin C helps neutralize free radicals and helps iron get absorbed in the body. No artificial colors. No artificial flavors. No preservatives. No chemical s |
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Nature Made Time-Release Vitamin C Supplement Tablets with Rose Hips, 1000 mg, 60-Count Bottles (Pack of 3) by Nature Made Nature Made Vitamin C 1000mg w/ Rose Hips TR. 3-pack/60-count |
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Emergen-C Vitamin C Fizzy Drink Mix, 1000 mg, Lemon-Lime, 0.3 Ounce Packets (Pack of 36) by Emer'gen-C A dietary supplement. Super energy booster! 100 mg Vitamin C as seven mineral ascorbates. 32 Active mineral complexes and B Vitamins. A powerful antioxidant. Electrolyte balanced. (These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.) Just add water. Fits in a shirt pocket or purse. Made in the USA. |
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Kirkland Signature Chewable Vitamin C 500 mg Tangy Orange Taste - 500 Tablets by Kirkland Signature Chewable Vitamin C enhances the Immune system and protects the body's cells from potential oxidative damage. Chewable tablets are ideal for individuals who may have difficulty swallowing solid tablets. |
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TwinLab C-1000 Caps, 1000 mg, 250 Capsules (Pack of 2) by Twinlab Dietary Supplement. Crystalline Vitamin C. TwinLab C-1000 Caps are easier to swallow and assimilate. Well tolerated by most highly allergic individuals. No tablet binders, coatings or colorings. Free of the most common allergens such as yeast, barley, whe |
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