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A promising new approach to cadmium induced hepatoxicity: Cytoprotective effect of midkine
January 17, 2008Cadmium comes from a wide variety of sources in the environment and from industry and is extremely toxic to humans. Environmental exposure can occur via the diet and drinking water. In chronic exposure, it also accumulates in the body, particularly in the kidneys and the liver. The liver acts as a detoxification organ. It filters the blood coming from the gastrointestinal tract and liver cells can be exposed to almost whole ingested and absorbed molecules and toxins at their highest concentrations through the portal vein. At present, there is no effective treatment for cadmium intoxication other than symptomatic treatment. Some chelating compounds are used for this purpose.
A research article published on January 7, 2008 in the World Journal of Gastroenterology (volume 14, issue 1) addresses this problem. An understanding of the processes that ensure self-protection against toxic substances is essential for the development and application of new therapeutic regimens. In research conducted in hepatocyte cell culture, cadmium exposure causes dose and time dependent damage in liver cells. Dr. Yazihan et al found cadmium intoxication stimulates secretion of midkine in a dose and time dependent manner. Midkine is mitogenic to cells. Midkine expression is found in the liver from early gestation. It is a heparin binding growth factor that regulates cell growth, survival, and differentiation. In this study it was found that exogenous midkine application induces hepatocyte proliferation. Midkine treatment prevented apoptosis, lactate dehydrogenase leakage and cytotoxicity caused by cadmium exposure in Hep3B cells. Midkine secretion might be one of the self defense mechanisms of the hepatocytes. The results of this study suggest a promising future therapy with midkine in cadmium induced hepatotoxicity. Midkine may also be beneficial to other hepatotoxic conditions.
World Journal of Gastroenterology
Cadmium Current Events and Cadmium News RSSTransforming Nanowires Into Nano-Tools Using Cation Exchange Reactions
A team of engineers from the University of Pennsylvania has transformed simple nanowires into reconfigurable materials and circuits, demonstrating a novel, self-assembling method for chemically creating nanoscale structures that are not possible to grow or obtain otherwise.
Berkeley Researchers Find New Route to Nano Self-Assembly
If the promise of nanotechnology is to be fulfilled, nanoparticles will have to be able to make something of themselves. An important advance towards this goal has been achieved by researchers with the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) who have found a simple and yet powerfully robust way to induce nanoparticles to assemble themselves into complex arrays.
Harvard scientists bend nanowires into 2-D and 3-D structures
Taking nanomaterials to a new level of structural complexity, scientists have determined how to introduce kinks into arrow-straight nanowires, transforming them into zigzagging two- and three-dimensional structures with correspondingly advanced functions.
Water quality in orbit
Space is not a fun place to get a stomach bug. To ensure drinking water is adequately disinfected, University of Utah chemists developed a two-minute water quality monitoring method that just started six months of tests aboard the International Space Station.
Gold Solution for Enhancing Nanocrystal Electrical Conductance
In a development that holds much promise for the future of solar cells made from nanocrystals, and the use of solar energy to produce clean and renewable liquid transportation fuels, researchers with the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) have reported a technique by which the electrical conductivity of nanorod crystals of the semiconductor cadmium-selenide was increased 100,000 times.
Nanopillars Promise Cheap, Efficient, Flexible Solar Cells
Researchers at the U.S. Department of Energy's Lawrence Berkeley National Laboratory and the University of California at Berkeley have demonstrated a way to fabricate efficient solar cells from low-cost and flexible materials.
Making nanoparticles in artificial cells
Two new construction manuals are now available for the world's smallest lamps. Based on these protocols, scientists from the Max Planck Institute of Colloids and Interfaces have tailor-made nanoparticles that can be used as position lights on cell proteins and, possibly in the future as well, as light sources for display screens or for optical information technology.
Study shows transfer of heavy metals from water to fish in Huelva estuary
A team of researchers from the University of Cadiz has confirmed that zinc, copper and lead are present at high levels in the water and sediments of the Huelva estuary, and have studied how some of these heavy metals are transferred to fish.
New Nanocrystals Show Potential for Cheap Lasers, New Lighting
For more than a decade, scientists have been frustrated in their attempts to create continuously emitting light sources from individual molecules because of an optical quirk called "blinking," but now scientists at the University of Rochester have uncovered the basic physics behind the phenomenon, and along with researchers at the Eastman Kodak Company, created a nanocrystal that constantly emits light.
Singapore scientists synthesize gold to shed light on cells' inner workings
Highly fluorescent gold nanoclusters for sub-cellular imaging have been synthesized by researchers at the Institute of Bioengineering and Nanotechnology (IBN).
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I Send You this Cadmium Red by John Berger (Author), John Christie (Author) A book of correspondence between two highly talented friends-writer/critic/artist John Berger and filmmaker/artist John Christie-I Send You This Cadmium Red began in concept in February 1997, when Christie mused to Berger: "What could our next project be?" Berger replied: "Just send a color..." Soon after, a painted square of cadmium red crossed the English Channel, from Christie in London to Berger in France, and an amazing conversation began. The accompanying book reveals, in the form of letters, notes, small books, and drawings, their subsequent exchange of ideas on color-an visual odyssey that ranges from Matisse's blue to the blue of Yves Klein; from industrial brown anti-rust paint to Joseph Beuys' Braunkreuz, from mysterious cave paintings to Byzantine gold leaf. Unprecedented and... |
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Lenmar CBD366 3.6V 600mAh Nickel Cadmium Battery for Cordless Phones by LENMAR Lenmar's phone batteries keep you talking. Lenmar's batteries meet or exceed the original manufacturer's specifications and are fully compatible with your cordless phone. The wide range of phone batteries produced by Lenmar fit most of today's popular models.This is the 3AA battery with JST connector. |
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Gamblin Oil Color Cadmium Red Medium 150 ml tube by Gamblin Oil Color Gamblin Artist''s Oil Colors Gamblin Artist Colors are artists'' grade oil colors made from pure pigments and the finest refined linseed oil. The Gamblin factory is operated by a small company of oil painters led by Robert Gamblin. Considered America''s premiere colorman Robert Gamblin has made oil colors for the Smithsonian Institute. He formulates each color to preserve the unique textural and tinctorial differences among families of pigments. The Gamblin palette is composed of mineral colors including cobalt chemically pure cadmium and earth colors plus a full range of modern more transparent colors that retain their intensity when used in mixtures. When he teaches the history of artists'' colors in art schools throughout the English speaking world Robert Gamblin''s message is simple:... |
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6 AA 1.2V NiCd Rechargeable Batteries 1000mAh by Powerizer Six (6) rechargeable AA batteries. * Quantity: 6 * Capacity: 1000 mAh * Type: NiCd / Nickel Cadmium * Size: AA Voltage: 1.2V |
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Intergalactic Paradise Cadmium (Primary Contributor) |
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Nickel Cadmium Power Tools Battery For RYOBI 14.4 Volt by Batteries Nickel Cadmium Power Tools Battery For RYOBI 14.4 Volt |
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Xcelite XP1B 3.6v Nickel-Cadmium Battery for XP1 Cordless Driver by Cooper Tool Cooper Hand Tools, a division of Cooper Industries, Inc., manufactures and markets many well-known brands of hand tools, chain, and electronic soldering products, including Campbell chain, Crescent brand wrenches and pliers, Lufkin measuring tools, Nicholson files and saws, Plumb hammers, H.K. Porter bolt cutters, Weller soldering products, and Wiss snips. Headquartered in Apex, North Carolina, Cooper Hand Tools has manufacturing facilities in six domestic and seven international locations, and has approximately 4,000 employees worldwide. |
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Nickel Cadmium Power Tools Battery For DeWalt DW995K-2 by Batteries |
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Edelbrock 8036 Cadmium Throttle Cable Bracket by Edelbrock The Edelbrock Throttle Cable Brackets are designed with a specially extruded liner for extended life of the cable. This bracket is made of steel and is cadmium plated. This bracket comes with an Edelbrock carburetor with an added twist and a quick tune secondary air valve. It offers smooth transition from part to full throttle with leak free operation. The installation accessories include many of the small items you need for a smooth and trouble free installation. From throttle cable extensions and adapters to kick-down mounting brackets, all of it is perfectly matched and designed for easy use. |
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