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Rare Lung Disease Cells Indicate Higher Death Risk
January 17, 2008CINCINNATI-Large numbers of certain cells in the lungs of patients diagnosed with idiopathic pulmonary fibrosis may increase their chance of death, UC researchers have discovered.
According to a new study, increased numbers of neutrophil (pronounced new-tro-fil) cells-a type of white blood cell-in patients' lungs were associated with a 30 percent increased risk of mortality in the first year following diagnosis with idiopathic pulmonary fibrosis (IPF).
"A measure of cell types in the lungs of IPF patients at the time of diagnosis may allow us to determine their risk of death in the following year," says Brent Kinder, MD, assistant professor of medicine at the UC College of Medicine and pulmonologist with UC Physicians.
"This even takes into account other well-known measures of disease severity like age, whether or not the patient smokes and how well his or her lung functions during breathing tests," he adds.
Kinder co-authored the study, which is featured in the January issue of the journal Chest, with colleagues from the University of California, San Francisco (UCSF), and National Jewish Medical Center in Denver, Colo.
IPF is scarring of the lung. As the disease progresses, air sacs in the lungs become replaced by fibrotic scar tissue. Lung tissue becomes thicker where the scarring forms, causing an irreversible loss of the tissue's ability to carry oxygen into the bloodstream.
IPF is one of about 200 disorders called interstitial lung diseases (ILDs), which affect the thick tissue of the lung as opposed to more common lung ailments-such as asthma or emphysema-that affect the airways.
It is the most common form of ILD and affects about 128,000 people in the United States, with an estimated 48,000 new cases diagnosed each year. There currently are no proven therapies or cures for IPF.
Researchers discovered the link between neutrophils and IPF outcome using bronchoalveolar lavage. The technique involves passing a bronchoscope through the mouth of the patient and into the lungs. Saline is squirted into a small part of the affected lung and then recollected for examination.
The team evaluated the cell count of 156 people with IPF at the time the disease began to make its appearance.
"With this information, we can now work to identify neutrophil cells in patients' lungs and provide detailed information for more accurate diagnosis," says Kinder, who is also director of the newly established Interstitial Lung Disease Center at UC.
"It is our hope that this accurate prognostic information will become even more useful as effective treatments become available."
Kinder's research team included Talmadge King, Jr., MD, chair of internal medicine at UCSF and senior author of the study; Kevin Brown, MD, Marvin Schwarz, MD, and Alma Kervitsky from National Jewish Medical Center; and Joachim Ix, MD, from the University of California, San Diego.
The study was funded by grants from the National Heart, Lung and Blood Institute.
University of Cincinnati
"This even takes into account other well-known measures of disease severity like age, whether or not the patient smokes and how well his or her lung functions during breathing tests," he adds.
Kinder co-authored the study, which is featured in the January issue of the journal Chest, with colleagues from the University of California, San Francisco (UCSF), and National Jewish Medical Center in Denver, Colo.
IPF is scarring of the lung. As the disease progresses, air sacs in the lungs become replaced by fibrotic scar tissue. Lung tissue becomes thicker where the scarring forms, causing an irreversible loss of the tissue's ability to carry oxygen into the bloodstream.
IPF is one of about 200 disorders called interstitial lung diseases (ILDs), which affect the thick tissue of the lung as opposed to more common lung ailments-such as asthma or emphysema-that affect the airways.
It is the most common form of ILD and affects about 128,000 people in the United States, with an estimated 48,000 new cases diagnosed each year. There currently are no proven therapies or cures for IPF.
Researchers discovered the link between neutrophils and IPF outcome using bronchoalveolar lavage. The technique involves passing a bronchoscope through the mouth of the patient and into the lungs. Saline is squirted into a small part of the affected lung and then recollected for examination.
The team evaluated the cell count of 156 people with IPF at the time the disease began to make its appearance.
"With this information, we can now work to identify neutrophil cells in patients' lungs and provide detailed information for more accurate diagnosis," says Kinder, who is also director of the newly established Interstitial Lung Disease Center at UC.
"It is our hope that this accurate prognostic information will become even more useful as effective treatments become available."
Kinder's research team included Talmadge King, Jr., MD, chair of internal medicine at UCSF and senior author of the study; Kevin Brown, MD, Marvin Schwarz, MD, and Alma Kervitsky from National Jewish Medical Center; and Joachim Ix, MD, from the University of California, San Diego.
The study was funded by grants from the National Heart, Lung and Blood Institute.
University of Cincinnati
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New data: Hospital imaging centers poised to pull back, hitting patients hardest in rural areas
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Pitt team first to profile genes in acutely ill idiopathic pulmonary fibrosis patients
The first findings from a one-of-a-kind, patient-driven effort to provide lung tissue for research might help doctors predict when patients with idiopathic pulmonary fibrosis (IPF) are becoming dangerously ill and also could point the way to interventions that could sustain them until life-saving transplants can be performed.
Protein may be strongest indicator of rare lung disease, study shows
Researchers at the University of Cincinnati (UC) have discovered a protein in the lungs that can help in determining progression of the rare lung disease Idiopathic Pulmonary Fibrosis (IPF).
Large clinical trial finds pirfenidone may help lung function in IPF patients
A large, well-controlled, multi-national clinical trial program has demonstrated the effectiveness and safety of what may become the first FDA-approved medicine for idiopathic pulmonary fibrosis, or IPF.
UT Southwestern researchers identify gene linked to inherited form of fatal lung disease
Researchers at UT Southwestern Medical Center have determined that a mutation in a gene known for its role in defending the lungs against invading pathogens is responsible for some inherited cases of a lethal lung disease affecting older adults. The same mutation may also be associated with lung cancer, the researchers said.
Double threat: Deadly lung disease also linked to heart attacks
Patients with idiopathic pulmonary fibrosis (IPF) are three times as likely to experience severe coronary events-including heart attacks-than people without the disease.
Note to people with scarred and stiffened lungs: Monitor your sleep before severe fatigue sets in
Family, friends and neighbors remember Lisa Sandler Spaeth as an active mother of two in Potomac, Md., with a lot on the go, juggling her son's baseball games and her daughter's horseback-riding lessons with numerous committee obligations, organizing women's activities at her local synagogue.
Biomarkers identified for idiopathic pulmonary fibrosis
The first evidence of a distinctive protein signature that could help to transform the diagnosis and improve the monitoring of the devastating lung disease idiopathic pulmonary fibrosis (IPF) is being reported by University of Pittsburgh School of Medicine researchers in this month's edition of PLoS Medicine, an open-access journal of the Public Library of Science.
UCSF marks a milestone with 500th transplant in heart and lung program
UCSF marked a milestone this week with the 500th procedure in its Thoracic Transplant Program, which specializes in transplantation of the heart and lung.
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