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Breastfeeding now safer for infants of HIV-infected mothers
February 05, 2008First solid evidence that viral transmission through breast milk can be prevented by a drug
An antiretroviral drug already in widespread use in the developing world to prevent the transmission of HIV from infected mothers to their newborns during childbirth has also been found to substantially cut the risk of subsequent HIV transmission during breast-feeding.
In a study presented Feb. 4 at the 2008 Conference on Retroviruses and Opportunistic Infections in Boston, an international team of AIDS experts reports that nevirapine given once daily to breast-feeding infants from 8 to 42 days old decreased by almost half the rate of HIV transmission via breast-feeding at 6 weeks of age. The decrease occurred in comparison to a single dose of nevirapine given to infants at birth, the current standard of care. At 6 months of age, the risk of postnatal HIV infection or death in infants who received the six-week regimen was almost one-third less than the risk for infants given only a single dose. The study was led by three teams of investigators at The Johns Hopkins University in collaboration with investigators in Ethiopia, India and Uganda.
Breast-feeding remains a leading route of HIV transmission in the developing world. The United Nations World Health Organization estimates that approximately 150,000 infants are infected through breast-feeding each year. In the United States each year, fewer than 150 newborns are infected with HIV at birth, mostly to mothers who did not know they were HIV positive.
The study, conducted from 2001 to 2007 and involving approximately 2,000 infants, is one of the first randomized controlled trials to show that a drug can prevent HIV transmission to uninfected babies exposed to their infected mothers' breast milk.
According to Johns Hopkins scientists, the results are highly significant because the low-dose regimen of nevirapine was able to reduce transmission or death in breast-feeding infants. They note that the extended-nevirapine regimen appears to be as safe as the single-dose regimen.
The study is also significant, the scientists say, because it is the first to show that an antiretroviral drug can prevent HIV transmission through mucosal tissue.
This finding has implications for the potential value of antiretroviral drugs for preventing sexual transmission of HIV.
Johns Hopkins Medical Institutions
Breast-feeding remains a leading route of HIV transmission in the developing world. The United Nations World Health Organization estimates that approximately 150,000 infants are infected through breast-feeding each year. In the United States each year, fewer than 150 newborns are infected with HIV at birth, mostly to mothers who did not know they were HIV positive.
The study, conducted from 2001 to 2007 and involving approximately 2,000 infants, is one of the first randomized controlled trials to show that a drug can prevent HIV transmission to uninfected babies exposed to their infected mothers' breast milk.
According to Johns Hopkins scientists, the results are highly significant because the low-dose regimen of nevirapine was able to reduce transmission or death in breast-feeding infants. They note that the extended-nevirapine regimen appears to be as safe as the single-dose regimen.
The study is also significant, the scientists say, because it is the first to show that an antiretroviral drug can prevent HIV transmission through mucosal tissue.
This finding has implications for the potential value of antiretroviral drugs for preventing sexual transmission of HIV.
Johns Hopkins Medical Institutions
Breastfeeding Current Events and Breastfeeding News RSSAir pollution increases infants' risk of bronchiolitis
Infants who are exposed to higher levels of air pollution are at increased risk for bronchiolitis, according to a new study.
American Dietetic Association Releases Updated Position Paper Promoting and Supporting Breastfeeding
The American Dietetic Association has released an updated position paper on breastfeeding that details health benefits for both infants and mothers and encourages promotion of breastfeeding whenever possible.
Changes in brain chemicals mark shifts in infant learning
When do you first leave the nest? Early in development infants of many species experience important transitions-such as learning when to leave the protective presence of their mother to start exploring the wider world.
Maternal HIV-1 treatment protects against transmission to newborns
Mothers receiving highly active antiretroviral therapy (HAART) to treat HIV-1 infection are less likely than untreated mothers to transmit the virus to their newborns through breastfeeding.
Breast milk should be drunk at the same time of day that it is expressed
The levels of the components in breast milk change every 24 hours in response to the needs of the baby. A new study published in the journal Nutritional Neuroscience shows, for example, how this milk could help newborn babies to sleep.
Supplementing babies' formula with DHA boosts cognitive development
Research has shown that children who were breast fed as infants have superior cognitive skills compared to those fed infant formula, and it's thought that this is due to an essential fatty acid in breast milk called docosahexaenoic acid (DHA).
Health experts offer action steps local governments can use to cut childhood obesity rates
Zoning restrictions on fast-food restaurants near schools and playgrounds, community policing to improve safety around public recreational sites, requirements that publicly run after-school programs limit video game and TV time, and taxes on high-calorie, low-nutrient foods and drinks are some of the strategies local government officials can use to tackle the childhood obesity epidemic in their communities.
Mother's immune system may block fetal treatments for blood diseases
Pediatric researchers have resolved an apparent contradiction in the field of prenatal cell transplantation- a medical approach that holds future promise in correcting sickle cell disease and other serious congenital blood disorders.
Essential nutrient found in eggs may help lower risk of neural tube defects
Research published online in the journal Epidemiology found that higher levels of total blood choline are associated with a 2.5-fold reduction in risk for neural tube birth defects (NTDs).
New research reveals mothers need infant feeding information
A systematic literature review of mothers' experiences with bottle-feeding found that while mothers recognize the benefits of breastfeeding, those who bottle-feed with infant formula do not receive adequate information and support from their healthcare providers and thus, ultimately put their baby's health at risk.
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