New Jefferson Trial to Test Radiation-Emitting Beads Against Advanced Liver CancerFebruary 13, 2008Liver cancer specialists at Jefferson's Kimmel Cancer Center in Philadelphia are beginning an 18-month study of a new treatment for liver cancer. The therapy entails injecting tiny beads that emit small amounts of radiation into the liver's main artery while also blocking the blood supply feeding the cancer's growth. The technique, called radioembolization, has been approved by the federal Food and Drug Administration for use in inoperable liver cancer. This is the first time that the particular technology, called SIR-Spheres microspheres, which is FDA-approved for treating colon cancer that has spread to the liver, is being studied in patients with hepatocellular carcinoma, or primary liver cancer (cancer that originates in the liver). The trial, which is led by Brian Carr, M.D., FRCP, Ph.D., professor of Medical Oncology at Jefferson Medical College of Thomas Jefferson University, includes patients from the University of Texas' M.D. Anderson Cancer Center in Houston and the University of Pittsburgh. According to Dr. Carr, who is chief of the liver tumor program at the Kimmel Cancer Center and Thomas Jefferson University Hospital, the technique uses approximately 30-times more beads than other types or radioembolization. The teams plan to enroll 10 patients initially, and perhaps as many as 40 altogether. "No one knows if radioembolization will be better than just radiation, even though there are theoretical grounds for it," he notes. In the form of radioembolization being tested, millions of tiny beads or "microspheres" containing the radioactive isotope Yttrium-90 are injected through a catheter directly into the liver's hepatic artery, which also supplies blood to tumors. The microspheres, in addition to blocking blood flow to the tumor, emit targeted radiation directly to the cancer, sparing healthy tissue. Dr. Carr and his colleagues are encouraged by results from a recent clinical trial showing the effectiveness of a similar technique against advanced liver cancer. Reporting recently in the journal Hepatology, Dr. Carr and physicians at Northwestern University in Chicago found that injecting another type of Yttrium-90-containing beads (TheraSphere®) was effective in treating inoperable liver cancer even in patients whose portal vein was blocked by tumor. The treatment, he says, was as good as or better than using the current standard called chemoembolization, which involves directly injecting chemotherapy drugs into the liver through the hepatic artery. Because it involves dangerous, cell-killing drugs, he notes, doctors have sought liver cancer treatments that have fewer toxic effects. The treatment doesn't cure the cancer, but has been shown to often shrink tumors and help patients live longer. It can also be used for patients who have previously failed chemotherapy. "This extends the numbers of patients who can be treated with this much safer treatment," he says. "Using TheraSphere is just as safe with or without portal vein thrombosis, so it looks like it's a wonderful new treatment. It's much safer because these patients don't get chemotherapy side effects, such as nausea, hair loss and they generally don't need to be in the hospital except for the day of treatment, which is usually every three months. "The immediate objective is to get patients to live longer and ultimately, a cure," Dr. Carr says. "Right now the choices are surgery and or transplant. Ideally, if the radioembolization trial is successful, many of these patients would have their liver tumors shrunken to the point where surgery is possible. Some may be able to have a transplant. It would be a significant contribution to the field if we could downstage the tumors so we could do more transplants, which is the only cure." Thomas Jefferson University Hospital |
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| Related Liver Cancer Current Events and Liver Cancer News Articles Researchers Identify Role of Gene in Tumor Development, Growth and Progression Virginia Commonwealth University Massey Cancer Center and VCU Institute of Molecular Medicine researchers have identified a gene that may play a pivotal role in two processes that are essential for tumor development, growth and progression to metastasis. Toward explaining why hepatitis B hits men harder than women Scientists in China are reporting discovery of unusual liver proteins, found only in males, that may help explain the long-standing mystery of why the hepatitis B virus (HBV) sexually discriminates -- hitting men harder than women. Largest-ever database for liver proteins may lead to treatments for hepatitis Scientists at a group of 11 research centers in China are reporting for the first time assembly of the largest-ever collection of data about the proteins produced by genes in a single human organ. 1 disease, not 1 demographic The Asian continent has nearly four billion people living in 47 different countries, and each of these groups has their own unique set of health issues. But when they come to the United States, they're often lumped into one large demographic: "Asian/Pacific Islander." Parasite growth hormone pushes human cells to liver cancer Scientists have found that the human liver fluke (Opisthorchis viverrini) contributes to the development of bile duct (liver) cancer by secreting granulin, a growth hormone that is known to cause uncontrolled growth of cells. Certain cancers more common among HIV patients than non-HIV patients Researchers at UT Southwestern Medical Center have found that non-AIDS-defining malignancies such as anal and lung cancer have become more prevalent among HIV-infected patients than non-HIV patients since the introduction of anti-retroviral therapies in the mid-1990s. Discovery could improve hepatitis C treatment Walter and Eliza Hall Institute researchers are part of an international team that has discovered a genetic variation that could identify those people infected with hepatitis C who are most likely to benefit from current treatments. Sorafenib significantly improves the length of time before breast cancer worsens ne of the first of a series of trials to investigate the use of sorafenib - a targeted anti-cancer drug - for the treatment of advanced breast cancer has found that if it is combined with the chemotherapy drug, capecitabine, it makes a significant difference to the time women live without their disease worsening. Penn State College of Medicine research isolates liver cancer stem cells prior to tumor formation Penn State College of Medicine researchers, in collaboration with colleagues at the University of Southern California, have taken an important step in understanding the role of stem cells in development of liver cancer. New biomarker predicts response to hepatitis C treatment Researchers have identified the first genetic marker that predicts response to hepatitis C treatments, and a single letter of DNA code appears to make a huge difference. More Liver Cancer Current Events and Liver Cancer News Articles |
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