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Atherosclerosis solution is likely many years away
February 22, 2008It's the leading cause of heart disease and stroke: atherosclerosis--a disease characterized by the thickening of arterial walls, restricting blood flow like a narrow pipe. Preventing and reversing this disease is still largely a puzzle to scientists working to put all the right pieces into place and form a complete picture of health for millions of patients who suffer its devastating effects worldwide.
So notes a University of Kentucky researcher whose perspective is published in the current issue of Nature. Alan Daugherty, director of the University of Kentucky Cardiovascular Research Center, and Dr. Daniel Rader, an endocrinologist and researcher at the University of Pennsylvania, co-authored the article, which offers insight into the complex process of translating scientific discoveries in the laboratory into new therapies for atherosclerosis.
While advances have been made in understanding how genetics, metabolism of HDL and LDL cholesterol, the inflammatory process, blood clots, and blood pressure regulation all play a part in the atherosclerosis disease process, a solution is likely many years away and will require huge--but worthwhile--investments of time, money and collaboration across fields of study. Decisions remain about which drugs to advance to clinical trials and how to measure the success of those therapies, Daugherty and Rader note.
University of Kentucky
University of Kentucky
Atherosclerosis Current Events and Atherosclerosis News RSSMenopause-cardiology consensus statement on cardiovascular disease and on HRT
A menopause-cardiology consensus statement has called for direct action to prevent cardiovascular disease (CVD) in menopausal women. The statement also concludes that there is little evidence of increased CVD risk in taking HRT.
Vitamin B niacin offers no extra benefit to statin therapy in seniors already diagnosed with CAD
The routine prescription of extended-release niacin, a B vitamin (1,500 milligrams daily), in combination with traditional cholesterol-lowering therapy offers no extra benefit in correcting arterial narrowing and diminishing plaque buildup in seniors who already have coronary artery disease, a new vascular imaging study from Johns Hopkins experts shows.
Early end to key study on benefits of niacin, a B vitamin, in keeping arteries open was premature
Heart experts at Johns Hopkins are calling premature the early halt of a study by researchers at Walter Reed Army Medical Center and Washington Hospital Center on the benefits of combining extended-release niacin, a B vitamin, with cholesterol-lowering statin medications to prevent blood vessel narrowing.
Can charcoal fight heart disease in kidney patients?
Charcoal may provide a new approach to managing the high rate of heart disease in patients with advanced kidney disease, according to preliminary research being presented at the American Society of Nephrology's 42nd Annual Meeting and Scientific Exposition in San Diego, CA.
Experts unveil new CVD guidelines and position papers
Several new guidelines and position papers offering the most up to date information to ensure that clinicians practice evidence-based medicine were released at the Canadian Cardiovascular Congress 2009 this week.
Canadian scientists link fat hormone to death from potentially deadly blood infection
A new Canadian study has found that lower-than-normal levels of a naturally-occurring fat hormone may increase the risk of death from sepsis-an overwhelming infection of the blood which claims thousands of lives each year.
Healthy neighborhoods may be associated with lower diabetes risk
Individuals living in neighborhoods conducive to physical activity and providing access to healthy foods may have a lower risk of developing type 2 diabetes in a five-year period, according to a report in the October 12 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
Liver cells grown from patients' skin cells
Scientists at The Medical College of Wisconsin in Milwaukee have successfully produced liver cells from patients' skin cells opening the possibility of treating a wide range of diseases that affect liver function.
National report shines light on lupus 50-year treatment drought
Today, The Lewin Group, a national health care consulting firm, issued recommendations on ways to overcome the barriers that have obstructed lupus drug development resulting in no new drug approval for this disease in more than 50 years - since the Eisenhower Administration.
Calcium scans may be effective screening tool for heart disease
A simple, non-invasive test appears to be an effective screening tool for identifying patients with silent heart disease who are at risk for a heart attack or sudden death.
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Dyslipidemia and Atherosclerosis Essentials 2009 by Christie M. Ballantyne (Author), James H. O'Keefe (Author), Antonio M. Gotto (Author) The World's Leading Experts Provide all the 'Essentials' Needed to Manage Patients in the Office, on the Ward, and in the Intensive Care Unit! Written by key opinion leaders in the field of cardiology, Dyslipidemia Essentials integrates the latest clinical guidelines and trials into a practical step-by-step guide to the management of dyslipidemia. Important clinical trials, common management pitfalls, and other cardiovascular risk reduction measures are also emphasized. Topics include: Step-by-step guide to intensive LDL lowering; NCEP ATP III and AHA/ACC guideline Updates; Treatment of low HDL cholesterol and elevated triglyceride; 73 dyslipidemia trials and 17 drug summaries |
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Unclog Your Arteries : How I Beat Atherosclerosis by Gene McDougall (Author) Heart attack or bypass surgery? - or even if not- if you are overweight, have high blood pressure, high blood sugar, diabetes, high cholesterol, heart disease, or a family history of any, read this and then keep it for reference. |
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Molecular Mechanisms of Atherosclerosis by Joseph Loscalzo (Editor) Atherosclerosis is the most common cardiovascular disorder in western societies and is rapidly becoming similarly prevalent in the underdeveloped world. Written by notable authorities and providing text rich in illustrative figures, Molecular Mechanisms in Atherosclerosis addresses the fundamental mechanisms underlying atherothrombosis and delineates current views of the molecular and cellular basis of the process. The editor approaches the issue from a mechanistic perspective, and does so in the context of contemporary knowledge of molecular and cellular pathobiology. The book provides an epidemiological overview of atherosclerotic vascular disease, followed by a review of the genetics and genetic epidemiology. It focuses on the four fundamental mechanisms common to all risk... |
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Anatomical Artery Cholesterol Atherosclerosis - Progressively Clogged by GPI Cholesterol: 4-Stage cross section of an artery demonstrating arteriosclerosis in which the narrowing of the artery is due to a build up of fatty tissue (cholesterol) and plaque. 4-Stages: normal artery, fatty streak, fibrous plaque, and blockage. The stages cause a decrease in blood flow, which can lead to a blood clot or thrombus. All stages rotate on hinge pin. Suitable for Cardio-Vascular, Cardiology and Internal Medicine, general anatomical study, training for surgical dissection, or for patient education or demonstration of procedures. Quantity discounts available. Made of a durable, plastic material accurately designed and colored to represent the major structures and, in certain instances, lesions or other abnormalities as described above. We also have available the unique... |
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Journal of Atherosclerosis and Thrombosis by Japan Publications Trading Co | |
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Biochemistry of Atherosclerosis (Advances in Biochemistry in Health and Disease) by Sukhinder C. Kaur (Editor) At its present rate of growth, atherosclerosis will be the major cause of death from disease by the year 2020. Atherosclerosis is an extremely complex, biochemical, multifactorial process. This book will cover many aspects of atherogenesis, with particular emphasis on lipid and lipoprotein metabolism. We will cover all aspects of the regulation of cholesterol homeostasis and the importance of each pathway. This book will explore the role of nuclear hormone receptors on lipid and lipoprotein metabolism and their complex roles in atherogenesis. Finally, how the use of genetic studies can help sort out the immense complexities that mediate these aspects of atherogenesis will be discussed. |
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Nature Made Selenium Supplement Tablets, 200 mcg, 100-Count Bottles (Pack of 3) by Nature Made An antioxidant that complements Vitamin E to help protect cells from free radicals thought to be responsible for cellular damage. |
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Lipids and Atherosclerosis (Advances in Translational Medical Science) by Chris J. Packard (Author), Daniel J. Rader (Author) New discoveries in genetics, molecular, and cell biology are not only enhancing our understanding of the etiology and progression of disease, but are finding applications in the development of new drugs or the implementation of new kinds of therapy. This book provides an in-depth review of emerging areas in biomedical research at the interface of science and clinical medicine. Written by a team of well-known experts, Lipidology: Translational Medical Science presents an authoritative overview of key advances in biomedical research and reviews the most important recent advances in lipidology, highlighting their relationship to cardiovascular disease. |
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Transeophageal Echo Aorta with Heavy Atherosclerosis Photographic Poster Print, 40x30 by AllPosters.com AllPosters.com is the world's #1 seller of posters, prints, photographs, specialty products and framed art. We're dedicated to bringing our customers the best selection of high quality wall décor that is perfect for their home or office. Browse our catalog of over 300,000 items that include entertainment and specialty posters, decorative prints, and art reproductions. Whether you're looking for your favorite movie or music poster, a framed Monet reproduction, or a print of the Eiffel Tower you will find it at AllPosters.com. Visit our Amazon store today at www.amazon.com/allposters to find Special Offers and search by subject category or artist. AllPosters.com provides unmatched service with a 100% satisfaction guarantee. We ship internationally to over 80 countries. Decorate your... |
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Women, Stroke and the Red Dress: Cerebrovascular Disease in Women In most age groups, more men than women will have a stroke in a given year. However, more than half of total stroke deaths occur in women. At all ages, more women than men die of stroke. This talk will discuss the reasons for these disparities throughout a women's lifetime. |
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