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The structure of resistance
February 25, 2008Scientists in Paris solve the structure of proteins that allow bacteria to gain resistance to multiple antibiotics
A team of scientists from the University Paris Descartes has solved the structure of two proteins that allow bacteria to gain resistance to multiple types of antibiotics, according to a report in EMBO reports this month. This work provides new clues as to how bacteria adapt to resist antibiotics and how to design new drugs that counteract this defense mechanism.
Frédéric Dardel and colleagues crystallized both the narrow and broad-spectrum resistance forms of the antibiotic-modifying acetyltransferase enzyme. Their report reveals that the enzyme has a flexible active site that can evolve to accommodate new antibiotics, allowing the bacteria to break them down and render them useless. This explains why this type of enzyme is now carried by many bacteria struggling for survival in the antibiotic age.
More importantly, the research provides new insight for the design of new antibiotics that could evade this form of resistance, and new inhibitors that would extend the effectiveness of current antibiotics, both of which could help in the fight against the deadly infections becoming more frequent in hospitals.
European Molecular Biology Organization
More importantly, the research provides new insight for the design of new antibiotics that could evade this form of resistance, and new inhibitors that would extend the effectiveness of current antibiotics, both of which could help in the fight against the deadly infections becoming more frequent in hospitals.
European Molecular Biology Organization
Antibiotics Current Events and Antibiotics News RSSUCLA researchers reconstitute enzyme that synthesizes cholesterol drug lovastatin
Researchers from the UCLA Henry Samueli School of Engineering and Applied Science have for the first time successfully reconstituted in the laboratory the enzyme responsible for producing the blockbuster cholesterol-lowering drug lovastatin.
Progress made on group B streptococcus vaccine
Scientists supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have completed a Phase II clinical study that indicates a vaccine to prevent Group B Streptococcus (GBS) infection is possible.
Henry Ford Hospital study: A MRSA strain linked to high death rates
A strain of MRSA that causes bloodstream infections is five times more lethal than other strains and has shown to have some resistance to the potent antibiotic drug vancomycin used to treat MRSA, according to a Henry Ford Hospital study.
Bacteria 'launch a shield' to resist attack
Researchers from the University of Copenhagen and the Technical University of Denmark along with other collaborators in Denmark and the US found that the bacterium Pseudomonas aeruginosa can 'switch on' production of molecules that kill white blood cells - preventing the bacteria being eliminated by the body's immune system.
Pumpkin skin may scare away germs
The skin of that pumpkin you carve into a Jack-o'-Lantern to scare away ghosts and goblins on Halloween contains a substance that could put a scare into microbes that cause millions of cases of yeast infections in adults and infants each year.
Deadly stomach infection rising in community settings, Mayo Clinic study finds
Mayo Clinic researchers have found that a sometimes deadly stomach bug, Clostridium difficile is on the rise in outpatient settings.
New clinical guidelines for exacerbations in cystic fibrosis
The American Thoracic Society has released new clinical guidelines for the treatment of exacerbations in cystic fibrosis based on a review of the literature on current clinical practices.
Eating right, not supplements, is best at keeping your good bacteria healthy, dietitian says
Healthy eating, not supplements, is the best way to keep the good bacteria in your gut healthy, says a dietitian and researcher.
3-day course of antibiotics may be sufficient following tonsillectomy
Children who receive a three-day course of antibiotics following tonsillectomy rather than a seven-day course appear to have no differences in pain or how quickly they return to a normal diet and activity level.
Scientists visualize assembly line gears in ribosomes, cell's protein factory
Even as research on the ribosome, one of the cell's most basic machines, is recognized with a Nobel Prize, scientists continue to achieve new insights on the way ribosomes work.
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Fish Mox (Amoxicillin 250 mg) - 100 Caps by THOMAS LABS Fish-Mox exerts a bactericidal action on gram positive and some gram negative bacteria. Useful for control of some common bacterial diseases of fish including aeromonas and pseudomonas genera and mysobacterial group (gill diseases, chondrococcus). Add contents of one capsule (250 mg) into aquarium for each 10 gallons of water to be treated. Repeat in 24 hours. It is suggested that a partial water change be made between treatments. While duration of treatment depends on type and severity of infection, it is recommended that extended medication baths continue for a minimum of 5 days & for not more than 10 days. Discontinue treatment if no improvement is noted within 5 days. To remove harmless yellow color, change 20% of water and use charcoal filter until clear. |
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Antibiotics Simplified by Jason Gallagher (Author) Antibiotics Simplified is a succinct guide designed to bridge knowledge gained in basic sciences courses with clinical practice in infectious diseases. Introductory chapters explain the rationale behind the treatment of infectious diseases, describe a system for selecting antimicrobial agents and briefly review basic microbiology. Later chapters present relevant characteristics of drug classes, emphasizing clinical "pearls" for individual agents, and also include content on antifungals. The concise nature of the text allows for emphasis on key points, allowing readers to extract the most important characteristics of anti-infective drugs from the larger mass of material that they learn from detailed pharmacology textbooks. This is an ideal handbook for students as well as practicing... |
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First Aid Only Triple Antibiotic Ointment Pack, 0.5 Gram, 25-Count Boxes (Pack of 3) by First Aid Only Use this triple antibiotic ointment pack to treat all kinds of minor cuts, burns and abrasions. Helps prevent infection while it promotes healing. May be applied 2 to 3 times daily as the condition indicates. Active ingredients: neomycin and polymyxin B sulfates and bacitracin zinc ointment USP. |
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Fish Flex Cephalexin - 250 mg 100 capsules by THOMAS LABS Fish-Flex is for use in aquariums for treatment of bacterial activity. Add contents of one capsule (250 mg) into aquarium for each 10 gallons of water to be treated. Repeat in 24 hours. It is suggested that a partial water change be made between treatments. While duration of treatment depends on type and severity of infection, it is recommended that extended medication baths continue for a minimum of 5 days & for not more than 10 days. Discontinue treatment if no improvement is noted within 5 days. |
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Antibiotics Pocketcard 2009 by H. Hof (Author) Antibiotics pocketcard provides an initial choice of antimicrobial therapy for most common infections. These empirical therapies cover more than 90% of everyday scenarios. The reverse side of this durable plastic card shows a table of antimicrobial spectra for the most important antibiotics. **2009 edition, completely updated! **Initial choice of antimicrobials for: CNS, heart, blood, gastrointestinal tract, bones/joints, urogenital tract, eye, ENT, skin/soft tissue diseases, fever of unknown origin. **Antimicrobial agents against selected bacteria, e.g. streptococci, staphylococci. |
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Fish Mox Forte 500 mg x 100 ct by THOMAS LABS Fish-Mox Forte (Amoxicillin) exerts a bacterial action on gram-positive and some gram-negative bacteria. |
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Antibiotic Essentials 2009 by Burke Cunha MD (Author) Antibiotic Essentials is a concise, practical, and authoritative guide to the treatment and prevention of infectious diseases commonly encountered in adults. It covers 542 clinical infectious disease syndromes, HIV infection, 134 detailed drug summaries, pediatric infectious diseases, and a chest x-ray atlas. Topics include: Empiric Therapy Based on Clinical Syndrome; Initial Therapy Based on Isolates; Pending Susceptibility Testing; HIV Infection; Fungi, Parasites, Unusual Organisms; Antibiotic Prophylaxis and Immunizations; Drug Summaries |
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Fish Cycline (Tetracycline 250 mg) - 100 Caps by THOMAS LABS Non-prescription tetracycline labeled for fish or aquarium use for the control of common bacterial infections. Each capsule contains 250 mg tetracycline. Directions: Add contents of capsule to aquarium water at the rate of 1 per 10 gals. Repeat in 24 hours. Continue treatment for 5-10 days. |
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Neosporin Plus Pain Relief First Aid Antibiotic/Pain Relieving Ointment, Maximum Strength, 1-Ounce Tubes (Pack of 3) by Neosporin Bacitracin Zinc-Neomycin Sulfate-Polymyxin B Sulfate-Pramoxine HCI. Maximum Strength Pain Relief. Soothes painful cuts, scrapes and burns while preventing infection. Keep In: Kitchen; Bathroom; Workshop; Travel Bag. Soothes the pain of burns; Suitable for |
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