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Genetic Engineering & Biotechnology News reports on advances in miRNA

March 03, 2008

miRNA research is now one of the most interesting areas in the life science world, reports Genetic Engineering and Biotechnology News (GEN). Scientists around the globe are studying the effects of over- or underexpression of specific miRNAs on the development and inhibition of pathogenesis in a variety of diseases, according to an article titled "miRNA-Regulated Pathways" in the March 1 issue of GEN (http://www.genengnews.com/articles/chitem.aspx?aid=2382).

"The appeal of miRNA technology lies in its promise and broad applicability across a wide spectrum of biotechnology and medical research," notes John Sterling, Editor-in-Chief of GEN. "Increasing numbers of studies are focusing on conditions such as cancer, heart disease, and neurological disorders as well as on aging."

As more miRNAs are identified, researchers are correlating changes in miRNA levels with disease processes. For instance, scientists at the Wistar Institute recently identified miR-373 and miR-520c. Members of the same miRNA family, both were shown to promote tumor metastasis.

Also covered in the GEN article on miRNAs is research taking place at Asuragen, the University of Louisville, IBM, University of Texas Southwestern, Mira Therapeutics, and miRagen Therapeutics. In addition, GEN looks at the latest technologies and services from miRNA research enabling companies such as Exiqon, Sigma-Aldrich, Mirus Bio, Thermo Fisher Scientific, SuperArray Bioscience, and LC Sciences.

Mary Ann Liebert, Inc./Genetic Engineering News

Related MiRNA Current Events and MiRNA News Articles

MiRNA Current Events and MiRNA News RSS

MicroRNAs circulating in blood show promise as biomarkers to detect pancreatic cancer
A blood test for small molecules abnormally expressed in pancreatic cancer may be a promising route to early detection of the disease.

Predicting cancer prognosis
Researchers led by Dr. Soheil Dadras at the Stanford University Medical Center have developed a novel methodology to extract microRNAs from cancer tissues.

Research uncovers clues to virus-cancer link
In a series of recently-published articles, a research team from the University of North Carolina at Chapel Hill Lineberger Comprehensive Cancer Center has uncovered clues to the development of cancers in AIDS patients.

Genetic variations in miRNA processing pathway and binding sites help predict ovarian cancer risk
Genetic variations in the micro-RNA (miRNA) processing pathway genes and miRNA binding sites predict a woman's risk for developing ovarian cancer and her prospects for survival.

MicroRNA undermines tumor suppression
Scientists at the Whitehead Institute for Biomedical Research and the National University of Singapore have discovered the first microRNA (miRNA) capable of directly tamping down the activity of the well known tumor-suppressor gene, p53, While p53 functions to prevent tumor formation, the p53 gene is thought to malfunction in more than 50% of cancerous tumors.

NYU Langone Medical Center researchers find micro RNA plays a key role in melanoma metastasis
Scientists have long wondered how melanoma cells travel from primary tumors on the surface of the skin to the brain, liver and lungs, where they become more aggressive, resistant to therapy, and deadly.

Researchers identify another potential biomarker
Researchers from Boston University School of Medicine (BUSM) have demonstrated that a recently discovered class of molecule called microRNA (miRNAs), regulate the gene expression changes in airway cells that occur with smoking and lung cancer.

Gene variations alter risk of esophageal cancer
Variations in a common gene pathway may affect esophageal cancer risk, a dangerous and rapidly increasing type of cancer, according to research by scientists at The University of Texas M. D. Anderson Cancer Center.

Jefferson, Ohio State team find gene signature profile for metastasis
A common signature of tiny, specific pieces of non-coding genetic material known as microRNAs (miRNAs) may be directly involved in the spread of cancer to other parts of the body.

Yale scientists show that a microRNA can reduce lung cancer growth
A small RNA molecule, known as let-7 microRNA (miRNA), substantially reduced cancer growth in multiple mouse models of lung cancer, according to work by researchers at Yale University and Asuragen, Inc., published in the journal Cell Cycle.

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