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NIA uses Genomatix in stem cell research, suggests novel transcription factors for stemness
March 04, 2008Linkage of pluripotent stem cell-associated transcripts to regulatory gene networks
Genomatix Software with businesses in Munich, Germany and Ann Arbor, Michigan released today that the group of Kenneth R. Boheler at the National Institute on Aging, National Institutes of Health, Baltimore, Md published some remarkable work on embryonic stem (ES) cells.
In their work they first identified and validated ES cell predominant transcripts by SAGE and qRT-PCR methods. Then they employed extensive DNA promoter analysis based on the integrated Genomatix system in order to identify conserved cis-elements and putative trans-regulators. Framework analysis for promoter organization, as introduced by Genomatix, increased likeliness for functional significance of the candidate transcription factors. Predictions were experimentally verified by Chromosomal Immunoprecipitation assays.
The study led to the novel identification of two transcription factors, B-Myb and Maz which are implicated either in the maintenance of the undifferentiated stem cell state or in early steps of differentiation.
Genomatix Software GmbH
The study led to the novel identification of two transcription factors, B-Myb and Maz which are implicated either in the maintenance of the undifferentiated stem cell state or in early steps of differentiation.
Genomatix Software GmbH
Stem Cell Research Current Events and Stem Cell Research News RSSFirst reconstitution of an epidermis from human embryonic stem cells
Stem cell research is making great strides. This is yet again illustrated by a study carried out by the I-STEM* Institute (I-STEM/ Inserm UEVE U861/AFM), published in the Lancet on 21 November 2009. The I-STEM team, directed by Marc Peschanski has just succeeded in recreating a whole epidermis from human embryonic stem cells.
Researchers find potential treatment for Huntington's disease
Investigators at Burnham Institute for Medical Research (Burnham), the University of British Columbia's Centre for Molecular Medicine and Therapeutics and the University of California, San Diego have found that normal synaptic activity in nerve cells (the electrical activity in the brain that allows nerve cells to communicate with one another) protects the brain from the misfolded proteins associated with Huntington's disease.
UCI embryonic stem cell therapy restores walking ability in rats with neck injuries
The first human embryonic stem cell treatment approved by the FDA for human testing has been shown to restore limb function in rats with neck spinal cord injuries - a finding that could expand the clinical trial to include people with cervical damage.
Of mice and men: Stem cells and ethical uncertainties
The recent creation of live mice from induced pluripotent stem cells (iPSCs) not only represents a remarkable scientific achievement, but also raises important issues, according to bioethicists at The Johns Hopkins University's Berman Institute of Bioethics.
Endocrine Society calls for expanded scope and funding for stem cell research
Stem cell research holds great promise for the treatment of millions of Americans with debilitating and possibly fatal diseases.
Scientists develop novel method to generate functional hepatocytes for drug testing
Scientists have for the first time produced liver cells from adult skin cells using the induced pluripotent stem cell (iPSC) technology.
UCSD researchers pave the way for effective liver treatments
A combination of bioengineering and medical research at the University of California, San Diego has led to a new discovery that could pave the way for more effective treatments for liver disease.
Governor recognizes stem cell research at Einstein
Albert Einstein College of Medicine of Yeshiva University hosted a roundtable discussion on stem cell research with New York Governor David A. Paterson today.
How Proteins Talk to Each Other
Investigators at Burnham Institute for Medical Research (Burnham) have identified novel cleavage sites for the enzyme caspase-3 (an enzyme that proteolytically cleaves target proteins).
Reactive Oxygen's Role in Metastasis
Researchers at the Burnham Institute for Medical Research (Burnham) have discovered that reactive oxygen species, such as superoxide and hydrogen peroxide, play a key role in forming invadopodia, cellular protrusions implicated in cancer cell migration and tumor metastasis.
More Stem Cell Research Current Events and Stem Cell Research News Articles
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Stem Cell Research: Medical Applications And Ethical Controversy (The New Biology) by Joseph, Ph.D. Panno (Author) This is an informative reference to the technological advances, applications, and issues of stem cell research. The past few years have seen controversy and debate surrounding stem cell research. Because skin cells have the capability to divide - unlike most of the cells in our body - our skin can heal itself through the division of cells. Scientists have attempted to apply this concept to major organs, trying to see if stem cells can be used to make the repairs that post-mitotic cells cannot. "Stem Cell Research" is a comprehensive and interesting introduction to this popular new science for non-experts. Explaining how stems cells can be obtained from several places, including skin, bone marrow, and most usefully, embryos, this book covers all the fundamental aspects of stem cell... |
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The Stem Cell Divide: The Facts, the Fiction, and the Fear Driving the Greatest Scientific, Political, and Religious Debate of Our Time by Michael Bellomo (Author) There has been much recent debate about the merits, dangers, and nature of stem cell research. Some see in it the answer to every debilitating disease known to man, while others see it as a step away from human cloning. While the battle has raged, research is moving ahead, and California has already passed a measure that will give $3 billion in support to stem cell research. But as politics, religion, and the media weigh in on this complex issue, more and more of the scientific reality of stem cell research is getting lost. In the search for the truth about stem cell science, the author has interviewed the scientists whose cutting-edge research is at the very heart of this hot-button issue. The book explains what they have accomplished so far, what they're currently doing, and what... |
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The Stem Cell Controversy: Debating the Issues (Contemporary Issue Series) by Michael Ruse (Editor), Christopher A. Pynes (Editor) Stem cell research is headline news. Researchers are eager to move forward, state governments and private foundations are rushing to support it, and the sick and afflicted are desperate for its benefits. Yet powerful forces in our society—led by President George W. Bush—find it morally troubling and they are doing all in their powers to restrict its development beyond a very limited scale. Stem cells have the potential to develop into different parts of the body—skin, bone, nerves, blood, and more. Scientists usually harvest them from aborted fetal tissue or newly fertilized cells. This procedure has proved very unacceptable to the religious right. They argue that even a newly fertilized cell is fully human and has all of the rights of full-grown adults, and they find any use of... |
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Cell of Cells: The Global Race to Capture and Control the Stem Cell by Cynthia Fox (Author) Publication Date is March 26, 2007 |
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Mapping Stem Cell Research: Terra Incognita Starring: n/a Directed By: Maria Finitzo This fascinating documentary tells the story of Dr. Jack Kessler, the current chair of Northwestern University s Department of Neurology and Clinical Neurological Sciences, and his daughter, Allison. When Kessler was invited to head up the Neurology department at Northwestern, his focus was on using stem cells to help cure diabetes. However, after Allison was paralyzed from the waist down in a skiing accident, he changed the focus of his research to look for a cure for spinal cord injuries using embryonic stem cells. The film follows the constantly evolving interplay between the promise of new discoveries, the controversy of modern science, and the courage of people who live with devastating disease and injury. |
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The Stem Cell Debate (Facets) by Ted Peters (Author) Noted theologian and ethicist Ted Peters accessibly relates the science of stem cells and regenerative medicine in lay terms as he traces the deeply divided ethical debate to three very different moral frameworks and shows the deepest and legitimate concerns of each, including the secular ethical framework employed in most medical ethics. Peters also offers fundamental theological reflection on this great choice, especially insights from theological anthropology. Peters's work is not only a unique guide but also a real model for how honest, religiously informed ethics can be practiced today. |
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Stem Cells and The Future Of Regenerative Medicine by Committee on the Biological and Biomedical Applications of Stem Cell Research (Author), Commission on Life Sciences (Author), National Research Council (Author), Board on Neuroscience and Behavioral Health (Author), Institute of Medicine (Author) Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell research—specifically embryonic stem cell research—into the political crosshairs. President Bush’s watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic... |
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Stem Cell Research: New Frontiers in Science and Ethics by Nancy E. Snow (Editor) This timely volume brings together essays by an internationally distinguished and diverse group of scholars. Contributors thoughtfully explore the ethical, public policy, and scientific implications of embryonic and adult stem cell research. Part one of the book offers a variety of scientific and public policy perspectives, including essays on stem cell plasticity and using umbilical cord blood as an alternative source of pluripotent stem cells. Part two vigorously examines the ethics of stem cell research and considers issues of social justice, morality, and public policy. Scientific alternatives, a natural law perspective regarding federal funding, and a discussion of the possible moral complicity of Catholic researchers are among the distinctive contributions made to the stem... |
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Stem Cell Research (New Biology) by Joseph Panno (Author) | |
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Stem Cell Research Awareness Ribbon Mouse Pad by MyHeritageWear.com The Stem Cell Research Ribbon proudly displayed on a mouse pad. There is no better way to achieve awareness for the meaning of the Stem Cell Research Ribbon than to display it on your mouse pad for everyone to see. The mouse pad measures at 9.25 x 7.75, it is machine washable, and the colors will not fade or run. Start gaining awareness today by presenting your Stem Cell Research Ribbon mouse pad at work or at home. It is certain to keep your mouse rolling in style all while gaining support and awareness! |
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