 |
|
Make or break time for osteoporosis treatment
March 11, 2008Study shows that 50 percent of women stop their treatment within 1 year
Women who do not comply with treatment instructions for osteoporosis or who do not respond to treatment are more likely to suffer further fractures, which seriously affects their quality of life. There is an urgent need to provide support to these patients and address their issues when new therapies are assessed and new treatment guidelines drawn up, according to lead researcher Professor Cyrus Cooper from the MRC Epidemiology Resource Centre, University of Southampton, in the UK. His findings (1) will be published in the April issue of Osteoporosis International, a Springer journal.
Osteoporosis is an increasing global health problem and currently available therapies have been shown to reduce the risk of fragility fractures in postmenopausal women. Most patients gain bone mineral density within a year of treatment. However, surveys of osteoporotic patients show that compliance to treatment is low in practice, and up to 50% of patients stop their treatment within a year due in part to side-effects. In addition, clinical trials show that osteoporotic fractures have physical, psychological and social implications that can seriously affect patients' quality of life.
Cooper and colleagues' study, the Observational Study of Severe Osteoporosis (OSSO)*, looked at the number of fractures suffered by women who did not respond to drug therapy, and how treatment failure affected their health-related quality of life. A total of 1,885 70-year-old women with established osteoporosis and 'inadequate clinical response to osteoporosis drug therapy' were assessed over a year. The researchers used a combination of two questionnaires to measure their quality of life at the start of the study, and then after six months and after a year. 'Inadequate clinical response to osteoporosis drug therapy' is defined as either a fragility fracture despite therapy for one year, or discontinued drug treatment due to adverse effects and/or noncompliance.
A total of 209 fractures occurred in 166 women over the year. Women who had suffered fractures in the past were more likely to sustain a new fracture than those who had not. Quality of life scores were worse in women who suffered a fracture regardless of whether they had had a fracture in the past. General health perception, social function and pain were the worst rated quality of life measures.
These findings show that the risk of fracture is high in women after failed osteoporosis therapy and the presence of a previous fracture in the previous 12 months strongly predicts a fracture in the next 12 months. The improvement in quality of life in the absence of fractures was significant, indicating the need for effective treatments for patients with osteoporosis.
###
*OSSO was a multi-national, 12-month prospective observational study across 469 out-patient settings in six European countries: France, Germany, Greece, Portugal, Spain and the UK. Women were recruited between April 2003 and June 2004.
Reference
1. Cooper C et al (2008). Fracture incidence and changes in quality of life in women with an inadequate clinical outcome from osteoporosis therapy: the Observational Study of Severe Osteoporosis (OSSO). Osteoporosis International (DOI 10.1007/s00198-007-0488-8)
Springer
Cooper and colleagues' study, the Observational Study of Severe Osteoporosis (OSSO)*, looked at the number of fractures suffered by women who did not respond to drug therapy, and how treatment failure affected their health-related quality of life. A total of 1,885 70-year-old women with established osteoporosis and 'inadequate clinical response to osteoporosis drug therapy' were assessed over a year. The researchers used a combination of two questionnaires to measure their quality of life at the start of the study, and then after six months and after a year. 'Inadequate clinical response to osteoporosis drug therapy' is defined as either a fragility fracture despite therapy for one year, or discontinued drug treatment due to adverse effects and/or noncompliance.
A total of 209 fractures occurred in 166 women over the year. Women who had suffered fractures in the past were more likely to sustain a new fracture than those who had not. Quality of life scores were worse in women who suffered a fracture regardless of whether they had had a fracture in the past. General health perception, social function and pain were the worst rated quality of life measures.
These findings show that the risk of fracture is high in women after failed osteoporosis therapy and the presence of a previous fracture in the previous 12 months strongly predicts a fracture in the next 12 months. The improvement in quality of life in the absence of fractures was significant, indicating the need for effective treatments for patients with osteoporosis.
###
*OSSO was a multi-national, 12-month prospective observational study across 469 out-patient settings in six European countries: France, Germany, Greece, Portugal, Spain and the UK. Women were recruited between April 2003 and June 2004.
Reference
1. Cooper C et al (2008). Fracture incidence and changes in quality of life in women with an inadequate clinical outcome from osteoporosis therapy: the Observational Study of Severe Osteoporosis (OSSO). Osteoporosis International (DOI 10.1007/s00198-007-0488-8)
Springer
Osteoporosis Current Events and Osteoporosis News RSSFlaxseed oil and osteoporosis
Animal studies suggest that adding flaxseed oil to the diet could reduce the risk of osteoporosis in post-menopausal women and women with diabetes, according to a report to be published in the International Journal of Food Safety, Nutrition and Public Health.
Heart and bone damage from low vitamin D tied to declines in sex hormones
Researchers at Johns Hopkins are reporting what is believed to be the first conclusive evidence in men that the long-term ill effects of vitamin D deficiency are amplified by lower levels of the key sex hormone estrogen, but not testosterone.
Connection between depression and osteoporosis detailed by Hebrew University researchers
Research carried out among thousands of people has shown a clear connection between depression and a loss of bone mass, leading to osteoporosis and fractures.
Nation's hip fracture rate could drop 25 percent with aggressive osteoporosis prevention
Aggressively managing patients at risk for osteoporosis could reduce the hip fracture rate in the United States by 25 percent, according to a Kaiser Permanente study published in the November issue of the Journal of Bone & Joint Surgery.
Fabled 'vegetable lamb' plant contains potential treatment for osteoporosis
The "vegetable lamb" plant - once believed to bear fruit that ripened into a living baby sheep - produces substances that show promise in laboratory experiments as new treatments for osteoporosis, the bone-thinning disease.
New data: Hospital imaging centers poised to pull back, hitting patients hardest in rural areas
Survivors and patients with cancers and heart disease, along with patient advocate organizations and physicians, today urged policymakers to enhance early diagnosis of deadly diseases by preserving access to advanced imaging, such as MRI and CT scans, in final health care reform legislation.
New approach for growing bone comes from Duke preclinical research
The natural cycle of building bone to maintain skeletal strength and then breaking it down for the body's calcium needs is delicately balanced, but diseases like osteoporosis break down too much bone without adequate bone replacement, leading to bone fractures.
New link found between osteoporosis and coeliac disease
People with coeliac disease may develop osteoporosis because their immune system attacks their bone tissue, a new study has shown.
National report shines light on lupus 50-year treatment drought
Today, The Lewin Group, a national health care consulting firm, issued recommendations on ways to overcome the barriers that have obstructed lupus drug development resulting in no new drug approval for this disease in more than 50 years - since the Eisenhower Administration.
Breast milk should be drunk at the same time of day that it is expressed
The levels of the components in breast milk change every 24 hours in response to the needs of the baby. A new study published in the journal Nutritional Neuroscience shows, for example, how this milk could help newborn babies to sleep.
More Osteoporosis Current Events and Osteoporosis News Articles
 |
The Whole-Body Approach to Osteoporosis: How to Improve Bone Strength and Reduce Your Fracture Risk by R. Keith Mccormick (Author) No pill will cure you of osteoporosis. While medication can sometimes help, it won't fully address the underlying causes of your osteoporosis or osteopenia. To restore bone health, you'll need a targeted program combining the best bone-building strategies from traditional and holistic medicine. The Whole-Body Approach to Osteoporosis distills these complex strategies into a whole-body plan you can begin today to dramatically improve your bone strength and overall vitality. This comprehensive guide includes information on: What to eat for stronger bones Choosing bone-building supplements and osteoporosis medications Foods and medications that may be contributing to bone loss Signs and symptoms that can help you monitor your bone health How lab tests can help you personalize your... |
 |
The Myth of Osteoporosis by Gillian Sanson (Author) "Gill Sanson's book is a well-researched breath of fresh air that will help women everywhere better trust the wisdom of their bodies." -- Christiane Northrup, M.D. The Myth of Osteoporosis is a research-based work that provides clear insight into the myths of osteoporosis. These myths motivate both patient and physician into a lifetime of unnecessary testing and drug therapy — therapy that can in fact be life-threatening. Gillian Sanson's well-documented explanation of these myths can spare women great anxiety. She takes the fear out of aging and restores women's sense of control over their bodies. She gives women good reasons for challenging the common way that osteoporosis is handled in the United States and in many other industrialized nations. |
 |
Osteoporosis: An Exercise Guide by Margie Bissinger (Author), Margie Bissinger (Editor), Cecil Byk (Editor) One of the most practical exercise guides written to help fight against osteoporosis and low bone mass. Ms. Bissinger utilizes her years of experience teaching and treat patients to create an easy to use, simple exercise guide. Beautifully illustrated, the exercises offer an effective program to improve strength, balance, and posture. Thanks to her years as a physicial therapist, she has provided an unique section illustrating safe ways to perform many activities one performs on a daily basis. Safe ways to perform simple acts such as sitting, lifting, and sneezing are demonstrated in her section on "activities of Daily Living". |
 |
Building Bone Vitality: A Revolutionary Diet Plan to Prevent Bone Loss and Reverse Osteoporosis--Without Dairy Foods, Calcium, Estrogen, or Drugs by Amy Lanou (Author), Michael Castleman (Author) Calcium pills don't work. Dairy products don't strengthen bones. Drugs may be dangerous. For years, doctors have been telling us to drink milk, eat dairy products, and take calcium pills to improve our bone vitality. The problem is, they’re wrong. This groundbreaking guide uses the latest clinical studies and the most upto- date medical information to help you strengthen your bones, reduce the risk of fractures, and prevent osteoporosis. You’ll learn why there’s no proof of calcium’s effectiveness, despite what doctors say, and why a low-acid diet is the only effective way to prevent bone loss. "This clear, convincing explanation of osteoporosis will change the way the world thinks about bone health. Lanou and Castleman prove beyond... |
 |
OsteoPeak Natural Personalized Bone Care Solution, 180 Capsules by OsteoPeak OsteoPeak® Natural is a new dietary supplement for increasing bone mineral density without any hormonal ingredients. OsteoPeak® Natural contains OPB¿ (OsteoPeak Proprietary Blend), a patented herbal blend of Rehmannia glutinosa Libosch and Eleutherococcus senticosus Max. One ingredient of the blend stimulates the activity of bone-forming cells while another inhibits the activity of bone-destroying cells. OsteoPeak® Natural brings superior benefits for strong healthy bones that other supplements alone cannot bring. |
 |
Preventing and Reversing Osteoporosis : What You Can Do About Bone Loss--A Leading Expert's Natural Approach to Increasing Bone Mass by Alan Gaby (Author) You Can Fight—and Even Reverse—Bone Loss How strong are your bones? At 35, a woman's battle against bone loss begins. And, it intensifies with menopause and beyond. Conventional medicine has offered such controversial therapies as estrogen replacement, a treatment that is potentially dangerous and only partially effective. Now, Dr. Gaby, one of the foremost authorities on nutritional and natural medicine, offers practical advice on osteoporosis that substantially increases a woman's chances for maintainting and even regaining normal bone mass. Inside you'll learn: ·How diet can help or hurt your bones ·How food allergies contribute to osteoporosis ·Which types of exercise are beneficial ·Why vitamin K is as important for bones as calcium ·And much more!... |
 |
Osteoporosis For Dummies (For Dummies (Health & Fitness)) by Carolyn Riester O'Connor (Author), Sharon Perkins RN (Author) Facts and advice to help people understand and prevent osteoporosis There are an estimated 55 million Americans over the age of 50 who have low bone mass. This easy-to-understand guide helps readers assess their risk and find a practical approach to the diagnosis, treatment, and prevention of osteoporosis. It covers bone density tests and a wide range of treatment options for osteoporosis-from hormone replacement therapy and acupuncture to calcium-rich foods, supplements, and exercise-and offers pointers on preventing broken hips and other common fractures. |
 |
Skeletal Fitness by Mirabai Holland - Osteoporosis Prevention Bone Loading and Strength Training Exercises:A Workout For Bones Starring: MFA Mirabai Holland Directed By: F. Sebastian Marino Skeletal Fitness by Mirabai Holland® is a 1 hour Bone Loading video to help combat osteoporosis by leading exercise expert, Mirabai Holland, M.F.A. Bones are living tissue and become more dense with exercise. Studies show that tennis players, through repeated practice, will develop thicker, stronger bones in their racquet arm than in their other arm. This process is called bone loading. Skeletal Fitness™is a comprehensive bone loading program for the whole body, with special emphasis on the areas at risk for osteoporotic fracture: the spine, thigh bone at the hip, and forearm at the wrist. Skeletal Fitness™ video includes: A one-on-one bone loading workout divided into 6 color coded sections making it easy for beginners to stop and go, or fast forward to any section that needs... |
 |
Better Bones, Better Body : Beyond Estrogen and Calcium by Susan Brown (Author), Susan E. Brown PhD (Author), Russell Jaffe MD (Author) Challenging traditional assumptions that estrogen and calcium deficiencies are the only causes of osteoporosis, this book explores the disorder from a wider perspective that includes lifestyle and exercise. This newly revised second edition features a personal osteoporosis risk assessment questionnaire and a step-by-step program for strengthening bones and improving overall health and well-being. |
 |
What Your Doctor May Not Tell You About Osteoporosis: Help Prevent--and Even Reverse--the Disease that Burdens Millions of Women by Felicia Cosman (Author) With over 10 million Americanscurrently suffering from osteoporosis-and millions more at risk-awareness of the disease has been brought to the forefront. Many women try everything from calcium pills to lifting weights in hopes of increasing bone density to prevent this devastating condition. Dr. Felicia Cosman, who has specialized in osteoporosis for 15 years, asserts that every woman should be following a universal prevention plan.This comprehensive guide to a lifelong strategy covers everything women need to know, from the architecture of the condition, to methods for reducing risk factors, to preventative nutrition, exercise, supplements, and vitamins-and the latest findings about estrogen and hormone replacement therapy. But prevention may not be enough-bone density testing is also a... |
| © 2009 BrightSurf.com |