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A new finding in liver transplantation and antifibrinolytics?
March 13, 2008Orthotopic liver transplantation (OLT) is associated with severe bleeding and considerable transfusion requirements. There are several reasons for this severe bleeding in OLT. Hemostatic abnormalities remain a major cause.
This study, performed by a team led by Professor Wang Xuehao, is to be published in the March 7, 2008 issue of the World Journal of Gastroenterology.
Aprotinin, a serine protease inhibitor, is used increasingly often in surgeries during operations such as cardiac surgery and liver transplantation to reduce bleeding and transfusion .We performed a meta-analysis to study the effect of aprotinin used in OLT on the intraoperative requirement of blood products and the postoperative outcomes. This study clearly showed that aprotinin can reduce the intraoperative requirement of blood products and has no significant effect on the incidence of laparotomy for bleeding, thromboembolic events and mortality.
In the view of the authors, there are still some conflicting results on whether aprotinin can reduce blood loss or requirement of transfusion in orthotopic liver transplantation, and whether it can be beneficial to the postoperative outcomes. A systematic review of the literature was performed in the electronic database of Medline and the Clinical Trials Registry Databases to study the effect of aprotinin used in OLT on the intraoperative requirement of blood products and on the incidence of laparotomy for bleeding, thrombotic events and mortality.
Using meta-analysis as the statistical method, this research was performed by doctors from the Department of Anesthesiology, First Affiliated Hospital, Nanjing Medical University.
More clinic researches are needed to confirm the result.
World Journal of Gastroenterology
In the view of the authors, there are still some conflicting results on whether aprotinin can reduce blood loss or requirement of transfusion in orthotopic liver transplantation, and whether it can be beneficial to the postoperative outcomes. A systematic review of the literature was performed in the electronic database of Medline and the Clinical Trials Registry Databases to study the effect of aprotinin used in OLT on the intraoperative requirement of blood products and on the incidence of laparotomy for bleeding, thrombotic events and mortality.
Using meta-analysis as the statistical method, this research was performed by doctors from the Department of Anesthesiology, First Affiliated Hospital, Nanjing Medical University.
More clinic researches are needed to confirm the result.
World Journal of Gastroenterology
Liver Transplantation Current Events and Liver Transplantation News RSSThe use of stem cells in regenerative medicine may also be detrimental for health
The use of stem cells in regenerative medicine is not always beneficial for human health, it may even be harmful according to a work done by the University of Granada and University of León. Scientists have demonstrated that transplantation of human mononuclear cells isolated from umbilical cord blood exerted a deleterious effect in rats with liver cirrhosis.
UF scientists discover new explanation for controversial old patient-care technique
You might not know what it's called, but if you've had general anesthesia before surgery, especially after an accident, it is likely you have received Sellick's maneuver.
How to identify early graft dysfunction preoperatively?
Small-for-size graft dysfunction (SFSGD) following living-related liver transplantation (LRLT) is characterized by early graft dysfunction (EGD) when the graft-to-recipient body weight ratio (GRBWR) is below 0.8%.
Medication effective for acute liver failure in early stages of disease
The antidote for acute liver failure caused by acetaminophen poisoning also can treat acute liver failure due to most other causes if given before severe injury occurs, UT Southwestern Medical Center researchers and their colleagues at 21 other institutions have found.
Prompt diagnosis of ear infections can improve outcome for organ transplant recipients
Organ transplant recipients benefit significantly when they are monitored and receive prompt diagnosis and treatment for otitis media, a common inner ear infection.
Evaluation of standard liver volume formula for Chinese adults
Living donor liver transplantation (LDLT) has been used to alleviate the shortage of available liver donors. Accurate estimation of the standard liver volume (SLV) of the living donor and recipient is crucial.
Women, blacks, Medicare recipients less likely to be evaluated for liver transplantation
Patient race, gender and insurance status influence decisions about who will go on to receive liver transplants, according to a University of Pittsburgh School of Medicine study.
Lower tacrolimus doses is suitable for living donor liver transplantation with small-for-size graft
Several studies have shown that living donor liver transplant (LDLT) recipients required smaller doses of tacrolimus compared with deceased donor liver transplant (DDLT) patients, which indicated that liver regeneration could affect the metabolism of tacrolimus in LDLT.
Sequential TACE and cryosurgery can improve survival times for patients with HCC?
Hepatocellular carcinoma (HCC)--a liver cancer--is recognized as one of the most common cancers in the world that disproportionately affects Southeast Asians and Africans.
Metabolic bone disease in cirrhosis patients
Long-standing liver disease has long been recognized to result in fragile bones with increased risk of fractures. In various international studies, the overall incidence has varied from 11% to 48%, with a fracture rate of 3%-44%.
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