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A new finding in liver transplantation and antifibrinolytics?
March 13, 2008Orthotopic liver transplantation (OLT) is associated with severe bleeding and considerable transfusion requirements. There are several reasons for this severe bleeding in OLT. Hemostatic abnormalities remain a major cause.
This study, performed by a team led by Professor Wang Xuehao, is to be published in the March 7, 2008 issue of the World Journal of Gastroenterology.
Aprotinin, a serine protease inhibitor, is used increasingly often in surgeries during operations such as cardiac surgery and liver transplantation to reduce bleeding and transfusion .We performed a meta-analysis to study the effect of aprotinin used in OLT on the intraoperative requirement of blood products and the postoperative outcomes. This study clearly showed that aprotinin can reduce the intraoperative requirement of blood products and has no significant effect on the incidence of laparotomy for bleeding, thromboembolic events and mortality.
In the view of the authors, there are still some conflicting results on whether aprotinin can reduce blood loss or requirement of transfusion in orthotopic liver transplantation, and whether it can be beneficial to the postoperative outcomes. A systematic review of the literature was performed in the electronic database of Medline and the Clinical Trials Registry Databases to study the effect of aprotinin used in OLT on the intraoperative requirement of blood products and on the incidence of laparotomy for bleeding, thrombotic events and mortality.
Using meta-analysis as the statistical method, this research was performed by doctors from the Department of Anesthesiology, First Affiliated Hospital, Nanjing Medical University.
More clinic researches are needed to confirm the result.
World Journal of Gastroenterology
In the view of the authors, there are still some conflicting results on whether aprotinin can reduce blood loss or requirement of transfusion in orthotopic liver transplantation, and whether it can be beneficial to the postoperative outcomes. A systematic review of the literature was performed in the electronic database of Medline and the Clinical Trials Registry Databases to study the effect of aprotinin used in OLT on the intraoperative requirement of blood products and on the incidence of laparotomy for bleeding, thrombotic events and mortality.
Using meta-analysis as the statistical method, this research was performed by doctors from the Department of Anesthesiology, First Affiliated Hospital, Nanjing Medical University.
More clinic researches are needed to confirm the result.
World Journal of Gastroenterology
Liver Transplantation News and Current Liver Transplantation Events RSSNoninvasive test accurately identifies advanced liver disease without biopsy
Non-invasively measuring liver stiffness with transient elastography accurately diagnoses patients with late-stage liver disease, reports a new study in Clinical Gastroenterology and Hepatology, the official journal of the American Gastroenterological Association (AGA) Institute.
Hepatitis C virus may need enzyme's help to cause liver disease
A key enzyme may explain how hepatitis C infection causes fatty liver - a buildup of excess fat in the liver, which can lead to life-threatening diseases such as cirrhosis and liver cancer, report University of Pittsburgh Graduate School of Public Health and School of Medicine researchers.
Is extra-corporal liver support with prometheus safe in patients with end-stage liver disease?
Patients with end-stage liver disease would benefit from liver supportive liver therapy while waiting for stabilization of hepatic functions or to enable bridging to liver transplantation.
Study concludes no racial disparities in long-term outcomes in recipients of liver transplants
New research published in the Journal of the American College of Surgeons shows long-term survival and liver rejection rates are equivalent for African-American liver transplant patients as compared with patients of other races.
New technique improves outcome for living donor liver transplants
The University of Alberta Hospital (UAH) is one of only a few centers in Canada that perform living donor liver transplantation, a surgical procedure developed in the late 1980s that expands the organ donor pool. About 80 liver transplants are done a year in Alberta, 10 of those being living-donor.
Survival rates exceed national averages for UCSF heart, liver and lung transplant programs
One-year survival rates for patients receiving heart, liver and lung transplants at UCSF Medical Center exceed national averages at statistically significant levels, according to new data compiled by the Scientific Registry of Transplant Recipients (SRTR).
Discovery of good -- and bad -- liver stem cells raises possibility of new treatment
Many scientists believe up to 40 percent of liver cancer is caused by stem cells gone wild - master cells in the organ that have lost all growth control. But, despite years spent looking, no one has ever found these liver "cancer stem cells" - or even normal stem cells in the organ. Until now.
Children's Hospital Physicians Publish Comprehensive Review of Liver Transplant Issues in Patients with Biliary Atresia
The most common indication worldwide for pediatric transplantation, biliary atresia is also the most common cause of chronic liver disease in newborns. Recently, Children's Hospital of Pittsburgh of UPMC physicians completed a review of issues that children with biliary atresia face that lead to the need for transplantation.
Who is the arch-criminal in the development of hepatopulmonary syndrome?
The hepatopulmonary syndrome (HPS) develops when an arterial oxygenation deficiency occurs due to intra-pulmonary vascular dilatations that are often associated with severe hepatic disease. HPS occurs in 15-20% of patients with liver cirrhosis undergoing evaluation for orthotopic liver transplantation.
A new chemotherapeutic target for hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a major health problem worldwide. Currently, the only chance for obtaining a cure in patients with HCC is by either a surgical resection or liver transplantation.
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