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Therapeutic cloning treats Parkinson's disease in mice
March 24, 2008Research led by investigators at Memorial Sloan-Kettering Cancer Center (MSKCC) has shown that therapeutic cloning, also known as somatic-cell nuclear transfer (SCNT), can be used to treat Parkinson's disease in mice. The study's results are published in the March 23 online edition of the journal Nature Medicine.
For the first time, researchers showed that therapeutic cloning or SCNT has been successfully used to treat disease in the same subjects from whom the initial cells were derived. While this current work is in animals, it could have future implications as this method may be an effective way to reduce transplant rejection and enhance recovery in other diseases and in other organ systems.
In therapeutic cloning or SCNT, the nucleus of a somatic cell from a donor subject is inserted into an egg from which the nucleus has been removed. This cell then develops into a blastocyst from which embryonic stem cells can be harvested and differentiated for therapeutic purposes. As the genetic information in the resulting stem cells comes from the donor subject, therapeutic cloning or SCNT would yield subject-specific cells that are spared by the immune system after transplantation.
The new study shows that therapeutic cloning can treat Parkinson's disease in a mouse model. The scientists used skin cells from the tail of the animal to generate customized or autologous dopamine neurons-the missing neurons in Parkinson's disease. The mice that received neurons derived from individually matched stem cell lines exhibited neurological improvement. But when these neurons were grafted into mice that did not genetically match the transplanted cells, the cells did not survive well and the mice did not recover.
Memorial Sloan-Kettering Cancer Center
The new study shows that therapeutic cloning can treat Parkinson's disease in a mouse model. The scientists used skin cells from the tail of the animal to generate customized or autologous dopamine neurons-the missing neurons in Parkinson's disease. The mice that received neurons derived from individually matched stem cell lines exhibited neurological improvement. But when these neurons were grafted into mice that did not genetically match the transplanted cells, the cells did not survive well and the mice did not recover.
Memorial Sloan-Kettering Cancer Center
Therapeutic Cloning Current Events and Therapeutic Cloning News RSSSmall mechanical forces have big impact on embryonic stem cells
Applying a small mechanical force to embryonic stem cells could be a new way of coaxing them into a specific direction of differentiation, researchers at the University of Illinois report. Applications for force-directed cell differentiation include therapeutic cloning and regenerative medicine.
Rice University's Baker Institute experts available to discuss stem cell research, recommendations
Rice University's Baker Institute has experts available to discuss the current debate on United States' embryonic stem cell policy.
Stem cell research puts interstate rivalry on hold
Victoria and New South Wales have put aside their competitive interstate rivalry to collaborate on a stem cell research project, as announced by Innovation Minister Gavin Jennings and NSW Minister for Science and Medical Research, Verity Firth, today.
DFG remains skeptical of the cloning of human cells
According to a paper published in the journal Stem Cells, an American group has succeeded in inserting cell nuclei from human skin cells into human enucleated oocytes and to stimulate these new cells to undergo cell division in the laboratory.
Widespread support for nonembryonic stem cell research, VCU Life Sciences Survey shows
The VCU Life Sciences Survey is the first poll to reflect the discovery reported internationally in November that human skin cells can be used to create stem cells or their near equivalents. When asked about the implications of this development, more than six in 10, or 63 percent, say that both embryonic and non-embryonic stem cell research is still needed, 22 percent say this development means embryonic stem cell research is no longer necessary.
Oosight microscope enables embryonic stem cell breakthrough
A noninvasive, polarized light microscope invented at the Marine Biological Laboratory (MBL) played a crucial role in a recent breakthrough in embryonic stem-cell research aimed at developing medical therapies.
Human clones: New U.N. analysis lays out world's choices
The world community quickly needs to reach a compromise that outlaws reproductive cloning or prepare to protect the rights of cloned individuals from potential abuse, prejudice and discrimination, according to authors of a new policy analysis by the United Nations University's Institute of Advanced Studies (www.ias.unu.edu).
UCLA researchers reprogram normal tissue cells into embryonic stem cells
Researchers at the Institute for Stem Cell Biology and Medicine at UCLA were able to take normal tissue cells and reprogram them into cells with the same unlimited properties as embryonic stem cells, the cells that are able to give rise to every cell type found in the body.
New hope for regenerative medicine
In the February 15th issue of G&D, Dr. K. John McLaughlin and colleagues report on their success in using uniparental embryonic stem cells to replace blood stem cells in mice.
In a technical tour de force, Salk scientists take a global view of the epigenome
A collaboration between researchers at the Salk Institute for Biological Studies and the University of California at Los Angeles captured the genome-wide DNA methylation pattern of the plant Arabidopsis thaliana-the "laboratory rat" of the plant world-in one big sweep.
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Overseeing research on therapeutic cloning: a private ethics board responds to its critics.: An article from: The Hastings Center Report by Ronald M. Green (Author), Kier Olsen DeVries (Author), Judith Bernstein (Author), Kenneth W. Goodman (Author), Robert Kaufmann (Author), Ann A. Kiessling (Author), Susan R. Levin (Author), Susan L. Moss (Author), Carol A. Tauer (Author) This digital document is an article from The Hastings Center Report, published by Hastings Center on May 1, 2002. The length of the article is 5161 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. From the author: Advanced Cell Technology's Ethics Advisory Board has been called window dressing for a corporate marketing plan. But the scientists and managers have paid attention, and the lawyers have gone along. Citation Details Title: Overseeing research on therapeutic cloning: a private ethics board responds to its critics. Author: Ronald M. Green Publication: The Hastings Center Report... | |
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Go Ahead (to therapeutic cloning) Spek Zimen (Primary Contributor) |
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Cloning: How and Why Directed By: Bill Stonebarger Also With: Hawkhill (Producer) Cloning is one of the most controversial of the new biotechnologies. This updated program takes students into Neal First's laboratory at the University of Wisconsin where the first cow was cloned from an embryonic cell. Students will learn some of the details of how cloning is done and will be challenged to consider the implications of this revolutionary technology for life in the 21st century. Transgenic animals, therapeutic cloning and the transplantation of both organs and cells are discussed and explained. |
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British fertility expert urges end of ban on human therapeutic cloning research.: An article from: Transplant News by Transplant Communications, Inc. (Publisher) This digital document is an article from Transplant News, published by Transplant Communications, Inc. on February 16, 2000. The length of the article is 327 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: British fertility expert urges end of ban on human therapeutic cloning research. Publication: Transplant News (Newsletter) Date: February 16, 2000 Publisher: Transplant Communications, Inc. Volume: 10 Issue: 3 Page: NA Distributed by Thomson... | |
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Prof. John Gearhart tells reporters the truth: "therapeutic cloning" produces a human embryo, no longer an "egg".(Brief Article): An article from: National Right to Life News by National Right to Life Committee, Inc. (Publisher) This digital document is an article from National Right to Life News, published by National Right to Life Committee, Inc. on March 1, 2003. The length of the article is 6688 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Prof. John Gearhart tells reporters the truth: "therapeutic cloning" produces a human embryo, no longer an "egg".(Brief Article) Publication: National Right to Life News (Magazine/Journal) Date: March 1, 2003 Publisher: National Right to Life Committee, Inc. Volume: 30 Issue: 3 Page: 23 Article Type: Brief Article Distributed by... | |
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First steps in therapeutic cloning taken as stem cells collected from cloned mouse embryos produce neurons, cells.(Brief Article): An article from: Transplant News by Transplant Communications, Inc. (Publisher) This digital document is an article from Transplant News, published by Transplant Communications, Inc. on May 12, 2001. The length of the article is 783 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: First steps in therapeutic cloning taken as stem cells collected from cloned mouse embryos produce neurons, cells.(Brief Article) Publication: Transplant News (Newsletter) Date: May 12, 2001 Publisher: Transplant Communications, Inc. Volume: 11 Issue: 9 Page: NA Article Type: Brief Article Distributed by Thomson... | |
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Human Therapeutic Cloning (Challenges and Opportunites) by Dr. Michael West (Author) | |
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Bush, Frist support total ban on human cloning; Senate to decide fate of therapeutic cloning in next few weeks.(Brief Article): An article from: Transplant News by Transplant Communications, Inc. (Publisher) This digital document is an article from Transplant News, published by Transplant Communications, Inc. on April 28, 2002. The length of the article is 416 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Bush, Frist support total ban on human cloning; Senate to decide fate of therapeutic cloning in next few weeks.(Brief Article) Publication: Transplant News (Newsletter) Date: April 28, 2002 Publisher: Transplant Communications, Inc. Volume: 12 Issue: 8 Page: NA Article Type: Brief Article Distributed by Thomson... | |
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ABA adopts recommendation opposing government action against researchers using therapeutic cloning methods.(American Bar Association)(Brief Article): An article from: Transplant News by Transplant Communications, Inc. (Publisher) This digital document is an article from Transplant News, published by Transplant Communications, Inc. on August 26, 2002. The length of the article is 580 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: ABA adopts recommendation opposing government action against researchers using therapeutic cloning methods.(American Bar Association)(Brief Article) Publication: Transplant News (Newsletter) Date: August 26, 2002 Publisher: Transplant Communications, Inc. Volume: 12 Issue: 16 Page: NA Article Type: Brief Article Distributed by Thomson... | |
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Therapeutic cloning in danger of being outlawed in US as lawmakers race to ban cloning of human beings.: An article from: Transplant News by Jim Warren Editor & Publisher (Author) This digital document is an article from Transplant News, published by Transplant Communications, Inc. on August 30, 2001. The length of the article is 1061 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Therapeutic cloning in danger of being outlawed in US as lawmakers race to ban cloning of human beings. Author: Jim Warren Editor & Publisher Publication: Transplant News (Newsletter) Date: August 30, 2001 Publisher: Transplant Communications, Inc. Volume: 11 Issue: 16 Page: NA Distributed by Thomson... |
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