 |
|
Umbilical cord blood cell therapy in an animal model of Alzheimer's disease
March 27, 2008A novel strategy based on targeted immune suppression using human umbilical cord blood cells may improve the pathology and cognitive decline associated with Alzheimer's disease, based on the results of a study in a mouse model of this currently untreatable neurodegenerative condition, as described in a groundbreaking report in Stem Cells and Development (www.liebertpub.com/scd), a peer-reviewed journal published by Mary Ann Liebert, Inc (www.liebertpub.com). The paper will be available free online (http://www.liebertonline.com/toc/scd/0/0).
Following a series of low-dose infusions of human umbilical cord blood cells into mice with Alzheimer's-like disease, the amount of amyloid-ß and ß-amyloid plaques-hallmarks of Alzheimer's pathology in the brain-was markedly reduced. Amyloid-ß induces an inflammatory response in the brain associated with the interaction of CD40 and CD40L, two pro-inflammatory molecules.
Human umbilical cord blood cell therapy was associated with suppression of CD40-CD40L activity, suggesting that this therapeutic approach modulates the activity of the immune system, offering the potential to target the pathogenic inflammatory response that may contribute to a variety of degenerative conditions, including Alzheimer's disease.
Jun Tan, PhD, MD, and colleagues from USF (Tampa), Yale University (New Haven, CT), Cedars-Sinai Medical Center (Los Angeles, CA), Saneron CCEL Therapeutics (Tampa, FL), and Saitama Medical School (Japan), concluded that human umbilical cord blood cell-induced disruption of the CD40-CD40L interaction may alleviate the key pathologic changes in the brain associated with Alzheimer's disease in a report entitled, "Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice."
"Previously, challenging observations have reported phenomena suggesting the non-hematologic therapeutic potential of blood stem cells. What is novel about this paper is its application to Alzheimer's disease, and a significant advance in characterizing the ameliorative mechanism of action" says Graham C. Parker, PhD, Editor-in-Chief of Stem Cells and Development, and a research professor in The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Children's Hospital of Michigan.
Mary Ann Liebert, Inc./Genetic Engineering News
Jun Tan, PhD, MD, and colleagues from USF (Tampa), Yale University (New Haven, CT), Cedars-Sinai Medical Center (Los Angeles, CA), Saneron CCEL Therapeutics (Tampa, FL), and Saitama Medical School (Japan), concluded that human umbilical cord blood cell-induced disruption of the CD40-CD40L interaction may alleviate the key pathologic changes in the brain associated with Alzheimer's disease in a report entitled, "Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice."
"Previously, challenging observations have reported phenomena suggesting the non-hematologic therapeutic potential of blood stem cells. What is novel about this paper is its application to Alzheimer's disease, and a significant advance in characterizing the ameliorative mechanism of action" says Graham C. Parker, PhD, Editor-in-Chief of Stem Cells and Development, and a research professor in The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Children's Hospital of Michigan.
Mary Ann Liebert, Inc./Genetic Engineering News
Umbilical Cord Blood Current Events and Umbilical Cord Blood News RSSUmbilical cord blood stem cell transplant may help lung, heart disorders
Two separate studies published in the current issue of Cell Transplantation (18:8), - now freely available on-line have shown that transplanted human-derived umbilical cord blood (UCB) stem cells transplanted in an animal model had positive therapeutic effects on specific lung and heart disorders the animal models.
U of M researchers find 2 units of umbilical cord blood reduce risk of leukemia recurrence
A new study from the Masonic Cancer Center, University of Minnesota shows that patients who have acute leukemia and are transplanted with two units of umbilical cord blood (UCB) have significantly reduced risk of the disease returning.
The use of stem cells in regenerative medicine may also be detrimental for health
The use of stem cells in regenerative medicine is not always beneficial for human health, it may even be harmful according to a work done by the University of Granada and University of León. Scientists have demonstrated that transplantation of human mononuclear cells isolated from umbilical cord blood exerted a deleterious effect in rats with liver cirrhosis.
NIH launches 2009 H1N1 influenza vaccine trials in HIV-infected pregnant women
The first clinical trials to test whether the 2009 H1N1 influenza vaccine can safely elicit a protective immune response in pregnant women launched yesterday, and a trial to conduct the same test in HIV-infected children and youth will begin next week.
Private umbilical cord banking not cost-effective, UCSF research shows
Private cord blood banking is not cost-effective because it costs an additional $1,374,246 per life-year gained, according to a new analysis by UCSF researchers.
Children's Hospital Oakland scientists first to discover new source for harvesting stem cells
A groundbreaking study conducted by Children's Hospital & Research Center Oakland is the first to reveal a new avenue for harvesting stem cells from a woman's placenta, or more specifically the discarded placentas of healthy newborns.
Just in time for spring: Scientists find the cellular on and off switch for allergies and asthma
If you're one of the millions who dread the spring allergy season, things are looking up.
World premiere in stem cell research in Montreal
A team from the Institute for Research in Immunology and Cancer (IRIC) at Université de Montréal has succeeded in producing a large quantity of laboratory stem cells from a small number of blood stem cells obtained from bone marrow.
Survey: Few physicians support private banking of umbilical cord blood
A survey of physicians has found broad support for the position that parents should not bank their newborns' umbilical cord blood in a private blood bank unless another member of the family is at risk for a blood disease that will require a stem cell transplant.
Scientists show gene mutation may cause immature lungs in newborns
Scientists have identified a gene critical to lung maturation in newborns and the production of surfactant, which lines lung tissues and prevents the lungs from collapsing.
More Umbilical Cord Blood Current Events and Umbilical Cord Blood News Articles
|
Umbilical Cord Blood Banking: Procedural ad Ethical Concerns for This New Birth Option.: An article from: Pediatric Nursing by Lydia Gonzalez-Ryan (Author), Karen Van Syckle (Author), Kelly D. Coyne (Author), Nicolle Glover (Author) This digital document is an article from Pediatric Nursing, published by Jannetti Publications, Inc. on January 1, 2000. The length of the article is 5306 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Umbilical Cord Blood Banking: Procedural ad Ethical Concerns for This New Birth Option. Author: Lydia Gonzalez-Ryan Publication: Pediatric Nursing (Refereed) Date: January 1, 2000 Publisher: Jannetti Publications, Inc. Volume: 26 Issue: 1 Page: 105 Distributed by Thomson... | |
 |
ABC News Nightline Your Child's Umbilical Cord If you could derive medical benefits by harvesting the blood from a freshly discarded umbilical cord, it's hard to think of any ethical reason why you shouldn't do so. As it is, about 3.5 million umbilical chords are thrown into the trash every year. Since that cord blood, as it's known, is rich in blood-forming stem cells, which can then be used in transplantation instead of bone marrow, saving it, storing it would seem to make eminently good sense. Indeed, there are already several thriving businesses that have grown up around that very premise. For a couple of thousand dollars or so, the companies will collect the blood from your baby's umbilical cord. And for about $100 a year, they'll store it in a refrigerated container. Then, should the baby or any immediate member of the... |
|
The effect of recombinant human bone morphogenetic protein-2 on untreated and CD34-selected umbilical cord blood.: An article from: Journal of the Alabama Academy of Science by Virginia C. Hughes (Author), Denise M. Harmening (Author) This digital document is an article from Journal of the Alabama Academy of Science, published by Alabama Academy of Science on January 1, 2004. The length of the article is 2126 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: The effect of recombinant human bone morphogenetic protein-2 on untreated and CD34-selected umbilical cord blood. Author: Virginia C. Hughes Publication: Journal of the Alabama Academy of Science (Refereed) Date: January 1, 2004 Publisher: Alabama Academy of Science Volume: 75 Issue: 1 Page: 25(8) Distributed by Thomson... | |
|
Umbilical Cord Blood an Ethical Stem Cell Trove.: An article from: Skin & Allergy News by Timothy F. Kirn (Author) This digital document is an article from Skin & Allergy News, published by International Medical News Group on September 1, 2001. The length of the article is 1370 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Umbilical Cord Blood an Ethical Stem Cell Trove. Author: Timothy F. Kirn Publication: Skin & Allergy News (Magazine/Journal) Date: September 1, 2001 Publisher: International Medical News Group Volume: 32 Issue: 9 Page: 1 Distributed by Thomson... | |
|
State pioneers umbilical cord blood system.(Trends in Medicine): An article from: Arkansas Business by Jamie Walden (Author) This digital document is an article from Arkansas Business, published by Journal Publishing, Inc. on April 6, 2009. The length of the article is 1786 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser. Citation Details Title: State pioneers umbilical cord blood system.(Trends in Medicine) Author: Jamie Walden Publication: Arkansas Business (Magazine/Journal) Date: April 6, 2009 Publisher: Journal Publishing, Inc. Volume: 26 Issue: 14 Page: 1(3) Distributed by Gale, a part of Cengage... | |
|
IOM calls for establishment of a national network to oversee storage, use of umbilical cord blood.(Institute of Medicine): An article from: Transplant News by Transplant Communications, Inc. (Publisher) This digital document is an article from Transplant News, published by Transplant Communications, Inc. on April 18, 2005. The length of the article is 907 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: IOM calls for establishment of a national network to oversee storage, use of umbilical cord blood.(Institute of Medicine) Publication: Transplant News (Newsletter) Date: April 18, 2005 Publisher: Transplant Communications, Inc. Volume: 15 Issue: 7 Distributed by Thomson... | |
|
Umbilical Cord Blood Stem Cell Use Increases.(Brief Article): An article from: Pediatric News by Timothy F. Kirn (Author) This digital document is an article from Pediatric News, published by International Medical News Group on September 1, 2001. The length of the article is 922 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Umbilical Cord Blood Stem Cell Use Increases.(Brief Article) Author: Timothy F. Kirn Publication: Pediatric News (Magazine/Journal) Date: September 1, 2001 Publisher: International Medical News Group Volume: 35 Issue: 9 Page: 4 Article Type: Brief Article Distributed by Thomson... | |
 |
ABC News Nightline Banking on your Future Storing umbilical cord blood is a growing phenomenon. Private cord blood banks across the country are providing storage for thousands of parents and there are a lot of parents out there who think they will be letting their children down if they don't participate. The question is, how useful are they? And if storing cord blood is a useful thing to do, should there be more public cord blood banks accessible to everyone, including those who might not be able to afford private banks? ABC News will examine the science and the social implications of this new trend in medicine. Is it an example of a scientific breakthrough vital to all, or an example of 'boutique medicine' dividing those with means from those without? Anchor: Ted Koppel Airdate: 10/4/2005 This product is manufactured on... |
|
Hematopoietic Potential and Alloreactive Capacity of Human Umbilical Cord Blood and Fetal Hematopoietic Tissue. 2005 Edition by Frans Lim (Author) | |
|
Two units of umbilical cord blood cells best for transplants in adults. (May Benefit Cell-Dose Problems).: An article from: Internal Medicine News by Mitchel L. Zoler (Author) This digital document is an article from Internal Medicine News, published by International Medical News Group on May 15, 2003. The length of the article is 6040 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Two units of umbilical cord blood cells best for transplants in adults. (May Benefit Cell-Dose Problems). Author: Mitchel L. Zoler Publication: Internal Medicine News (Magazine/Journal) Date: May 15, 2003 Publisher: International Medical News Group Volume: 36 Issue: 10 Page: 27(1) Distributed by Thomson... |
| © 2009 BrightSurf.com |