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Umbilical cord blood cell therapy in an animal model of Alzheimer's disease
March 27, 2008A novel strategy based on targeted immune suppression using human umbilical cord blood cells may improve the pathology and cognitive decline associated with Alzheimer's disease, based on the results of a study in a mouse model of this currently untreatable neurodegenerative condition, as described in a groundbreaking report in Stem Cells and Development (www.liebertpub.com/scd), a peer-reviewed journal published by Mary Ann Liebert, Inc (www.liebertpub.com). The paper will be available free online (http://www.liebertonline.com/toc/scd/0/0).
Following a series of low-dose infusions of human umbilical cord blood cells into mice with Alzheimer's-like disease, the amount of amyloid-ß and ß-amyloid plaques-hallmarks of Alzheimer's pathology in the brain-was markedly reduced. Amyloid-ß induces an inflammatory response in the brain associated with the interaction of CD40 and CD40L, two pro-inflammatory molecules.
Human umbilical cord blood cell therapy was associated with suppression of CD40-CD40L activity, suggesting that this therapeutic approach modulates the activity of the immune system, offering the potential to target the pathogenic inflammatory response that may contribute to a variety of degenerative conditions, including Alzheimer's disease.
Jun Tan, PhD, MD, and colleagues from USF (Tampa), Yale University (New Haven, CT), Cedars-Sinai Medical Center (Los Angeles, CA), Saneron CCEL Therapeutics (Tampa, FL), and Saitama Medical School (Japan), concluded that human umbilical cord blood cell-induced disruption of the CD40-CD40L interaction may alleviate the key pathologic changes in the brain associated with Alzheimer's disease in a report entitled, "Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice."
"Previously, challenging observations have reported phenomena suggesting the non-hematologic therapeutic potential of blood stem cells. What is novel about this paper is its application to Alzheimer's disease, and a significant advance in characterizing the ameliorative mechanism of action" says Graham C. Parker, PhD, Editor-in-Chief of Stem Cells and Development, and a research professor in The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Children's Hospital of Michigan.
Mary Ann Liebert, Inc./Genetic Engineering News
Jun Tan, PhD, MD, and colleagues from USF (Tampa), Yale University (New Haven, CT), Cedars-Sinai Medical Center (Los Angeles, CA), Saneron CCEL Therapeutics (Tampa, FL), and Saitama Medical School (Japan), concluded that human umbilical cord blood cell-induced disruption of the CD40-CD40L interaction may alleviate the key pathologic changes in the brain associated with Alzheimer's disease in a report entitled, "Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice."
"Previously, challenging observations have reported phenomena suggesting the non-hematologic therapeutic potential of blood stem cells. What is novel about this paper is its application to Alzheimer's disease, and a significant advance in characterizing the ameliorative mechanism of action" says Graham C. Parker, PhD, Editor-in-Chief of Stem Cells and Development, and a research professor in The Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Children's Hospital of Michigan.
Mary Ann Liebert, Inc./Genetic Engineering News
Umbilical Cord Blood Current Events and Umbilical Cord Blood News RSSChildren's national co-leads nationwide study of landmark sickle cell treatment
Children's National Medical Center immunologist and blood and marrow transplant physician Naynesh Kamani, MD, will serve as the study co-chair for a new national clinical trial of unrelated donor marrow and umbilical cord blood transplants for severe sickle cell disease.
Researchers grow human blood vessels in mice from adult progenitor cells
For the first time, researchers have successfully grown functional human blood vessels in mice using cells from adult human donors - an important step in developing clinical strategies to grow tissue, researchers report in Circulation Research: Journal of the American Heart Association.
Vitamin A pushes breast cancer to form blood vessel cells
Researchers at Georgetown University Medical Center have discovered that vitamin A, when applied to breast cancer cells, turns on genes that can push stem cells embedded in a tumor to morph into endothelial cells. These cells can then build blood vessels to link up to the body's blood supply, promoting further tumor growth.
Umbilical cord blood cell transplants may help ALS patients
A study at the University of South Florida has shown that transplants of mononuclear human umbilical cord blood (MNChUCB) cells may help patients suffering from Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease.
U of M Sets Course For Cure of Fatal Childhood Skin Disease
Physicians at the University of Minnesota and University of Minnesota Children's Hospital, Fairview have set the path to a cure for a young boy's fatal genetic skin disease, recessive dystrophic epidermolysis bullosa (RDEB), by using a cord blood and bone marrow transplant. Nate Liao, a 25-month-old from Clarksburg, N.J., underwent the experimental therapy in October 2007.
Omega-3 intake during last months of pregnancy boosts an infant's cognitive and motor development
A study supervised by Université Laval researchers Gina Muckle and Éric Dewailly reveals that omega-3 intake during the last months of pregnancy boosts an infant's sensory, cognitive, and motor development. The details of this finding are published in a recent edition of the Journal of Pediatrics.
Adult stem cells may be beneficial for certain cardiovascular disorders and autoimmune diseases
A review of previously published research suggests that stem cells harvested from an adult's blood or marrow may provide treatment benefit to select patients for some autoimmune diseases and cardiovascular disorders.
A functional immune system can be derived from embryonic stem cells, preliminary study finds
A new study demonstrates for the first time that embryonic stem cells can be used to create functional immune system blood cells, a finding which is an important step in the utilization of embryonic stem cells as an alternative source of cells for bone marrow transplantation.
Bacterial infections in premature babies more common than previously realized
Premature babies are subject to a host of threats that can result in fetal/neonatal disease. In a study published in the January 2008 issue of the American Journal of Obstetrics & Gynecology, researchers from the University of Alabama-Birmingham Medical School and the Drexel University College of Medicine found that genital mycoplasmas are a frequent cause of congenital fetal infection. 23% of neonates born between 23 and 32 weeks of gestation have positive umbilical blood cultures for two genital mycoplasmas (bacteria lacking cell walls): Ureaplasma urealyticum and Mycoplasma hominis.
Menstruation proves more than a curse
The cells which thicken the womb wall during a woman's menstrual cycle contain a newly discovered type of stem cell, and could be used in the treatment of damaged and/or old tissue.
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