Salivary diagnostics, the 'magic mirror' to your health ... at your personal computerApril 07, 2008Accuracy, convenience, and non-invasiveness are the most critical characteristics for any diagnostic tool. A new concept, Salivaomics Knowledge Base (SKB), an in silico (i.e., performed on computer or via computer simulation) saliva diagnostic atlas, is launching today during the 37th Annual Meeting of the American Association for Dental Research in Dallas, Texas. With people increasingly adopting a 'digital life', the SKB will serve as a catalyst for future development and expansion of salivary diagnostics. For over three years, saliva has shown genuine promise as a diagnostic tool for oral cancer detection. As a result, the scientific community and general public have developed a keen interest in its value. Central to the SKB is the recent creation of two diagnostic alphabets in saliva, the proteome and the transcriptome. In the SKB, the salivary proteome and transcriptome are mapped to 23 human chromosomes, totaling1166 distinct proteins and 851 unique mRNA transcripts in saliva. The available information presently includes profiles from healthy males and females, as well as oral cancer patients. These profiles can be used to determine distinct differences between groups of interest. For example, if one wants to know the differences in the salivary protein or transcriptome profiles of males and females, the user-friendly interface can be utilized to retrieve information from the database. First, an overview of the biomarker distribution on the 23 human chromosomes can be determined. Then, one can zoom in on specific gene segments to extract more detailed information, all done on one's personal computer. This is the first step of this SKB initiative. The database is expanding and will soon include information for pancreatic cancer, breast cancer, lung cancer, ovarian cancer, diabetes,and Alzheimer's disease. The short-term goal of the SKB is to share information with scientists globally in an effort to reduce redundancy and enhance the appeal of salivary diagnostics. International & American Association for Dental Research |
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| Related Saliva Current Events and Saliva News Articles Dartmouth researchers get personal with genetics Two recent studies by Dartmouth researchers use individual genetic data to reveal the powers and limits of our current understanding of how the genome influences human health and what genes can reveal about the ancestry of the people of New Hampshire. Anti-smoking law helps waiters to quit smoking Researchers from the Catalan Institute of Oncology have studied the impact of the law banning smoking in public places such as bars and restaurants on those working in these places. Vet says owners should exercise with their dogs based on specific needs to prevent obesity People and their dogs both need physical activity to fight obesity, and there are many exercises that owner and pet can do together that can improve their health and their relationship, according to a Kansas State University expert. MicroRNA in human saliva may help diagnose oral cancer Researchers continue to add to the diagnostic alphabet of saliva by identifying the presence of at least 50 microRNAs that could aid in the detection of oral cancer, according to a report in Clinical Cancer Research, a journal of the American Association for Cancer Research. University of Maryland researchers identify gene variant linked to effectiveness of plavix Researchers at the University of Maryland School of Medicine have identified a common gene variant carried by as many as a third of the general population that is believed to play a major role in determining why people do not respond to a popular anti-clotting medication, Plavix. Dental researchers confirm microRNAs as biomarkers for oral cancer detection A new study published by researchers at the UCLA School of Dentistry substantiates the effectiveness of measuring the microRNAs present in saliva to detect oral squamous cell carcinoma. Vet scientists' work on diagnostic, intervention tools for h1n1 helps human health lab, too If some day you are tested for the H1N1 virus without the painful prick of a needle, thank a pig -- and a team of Kansas State University researchers and their collaborators who are connecting animal and human health. Open wide and say 'zap' A group of researchers in Australia and Taiwan has developed a new way to analyze the health of human teeth using lasers. Researchers find genetic link between physical pain and social rejection UCLA psychologists have determined for the first time that a gene linked with physical pain sensitivity is associated with social pain sensitivity as well. Sleep patterns in children and teenagers could indicate risk for depression, researcher finds Sleep patterns can help predict which adolescents might be at greatest risk for developing depression, a researcher at UT Southwestern Medical Center has found in a five-year study. More Saliva Current Events and Saliva News Articles |
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