 |
|
Salivary diagnostics, the 'magic mirror' to your health ... at your personal computer
April 07, 2008Accuracy, convenience, and non-invasiveness are the most critical characteristics for any diagnostic tool. A new concept, Salivaomics Knowledge Base (SKB), an in silico (i.e., performed on computer or via computer simulation) saliva diagnostic atlas, is launching today during the 37th Annual Meeting of the American Association for Dental Research in Dallas, Texas.
With people increasingly adopting a 'digital life', the SKB will serve as a catalyst for future development and expansion of salivary diagnostics. For over three years, saliva has shown genuine promise as a diagnostic tool for oral cancer detection. As a result, the scientific community and general public have developed a keen interest in its value.
Central to the SKB is the recent creation of two diagnostic alphabets in saliva, the proteome and the transcriptome. In the SKB, the salivary proteome and transcriptome are mapped to 23 human chromosomes, totaling1166 distinct proteins and 851 unique mRNA transcripts in saliva. The available information presently includes profiles from healthy males and females, as well as oral cancer patients. These profiles can be used to determine distinct differences between groups of interest. For example, if one wants to know the differences in the salivary protein or transcriptome profiles of males and females, the user-friendly interface can be utilized to retrieve information from the database. First, an overview of the biomarker distribution on the 23 human chromosomes can be determined. Then, one can zoom in on specific gene segments to extract more detailed information, all done on one's personal computer.
This is the first step of this SKB initiative. The database is expanding and will soon include information for pancreatic cancer, breast cancer, lung cancer, ovarian cancer, diabetes,and Alzheimer's disease. The short-term goal of the SKB is to share information with scientists globally in an effort to reduce redundancy and enhance the appeal of salivary diagnostics.
International & American Association for Dental Research
This is the first step of this SKB initiative. The database is expanding and will soon include information for pancreatic cancer, breast cancer, lung cancer, ovarian cancer, diabetes,and Alzheimer's disease. The short-term goal of the SKB is to share information with scientists globally in an effort to reduce redundancy and enhance the appeal of salivary diagnostics.
International & American Association for Dental Research
Saliva Current Events and Saliva News RSSDartmouth researchers get personal with genetics
Two recent studies by Dartmouth researchers use individual genetic data to reveal the powers and limits of our current understanding of how the genome influences human health and what genes can reveal about the ancestry of the people of New Hampshire.
Anti-smoking law helps waiters to quit smoking
Researchers from the Catalan Institute of Oncology have studied the impact of the law banning smoking in public places such as bars and restaurants on those working in these places.
Vet says owners should exercise with their dogs based on specific needs to prevent obesity
People and their dogs both need physical activity to fight obesity, and there are many exercises that owner and pet can do together that can improve their health and their relationship, according to a Kansas State University expert.
MicroRNA in human saliva may help diagnose oral cancer
Researchers continue to add to the diagnostic alphabet of saliva by identifying the presence of at least 50 microRNAs that could aid in the detection of oral cancer, according to a report in Clinical Cancer Research, a journal of the American Association for Cancer Research.
University of Maryland researchers identify gene variant linked to effectiveness of plavix
Researchers at the University of Maryland School of Medicine have identified a common gene variant carried by as many as a third of the general population that is believed to play a major role in determining why people do not respond to a popular anti-clotting medication, Plavix.
Dental researchers confirm microRNAs as biomarkers for oral cancer detection
A new study published by researchers at the UCLA School of Dentistry substantiates the effectiveness of measuring the microRNAs present in saliva to detect oral squamous cell carcinoma.
Vet scientists' work on diagnostic, intervention tools for h1n1 helps human health lab, too
If some day you are tested for the H1N1 virus without the painful prick of a needle, thank a pig -- and a team of Kansas State University researchers and their collaborators who are connecting animal and human health.
Open wide and say 'zap'
A group of researchers in Australia and Taiwan has developed a new way to analyze the health of human teeth using lasers.
Researchers find genetic link between physical pain and social rejection
UCLA psychologists have determined for the first time that a gene linked with physical pain sensitivity is associated with social pain sensitivity as well.
Sleep patterns in children and teenagers could indicate risk for depression, researcher finds
Sleep patterns can help predict which adolescents might be at greatest risk for developing depression, a researcher at UT Southwestern Medical Center has found in a five-year study.
More Saliva Current Events and Saliva News Articles
 |
Cinco Diablo by Saliva Multi-platinum Island Records' five-man band Saliva has completed its aptly-titled fifth album, CINCO DIABLO, set to arrive in the physical and digital marketplace on December 16th - the ultimate alt-metal post-grunge must-have CD this twisted holiday season! The new album's first single pick, "Family Reunion," was #1 Most Added at Active Rock and Modern Rock radio and is already on over 75 stations at both formats. In advance support of CINCO DIABLO, Memphis favorites Saliva continue their never-ending headlining tour schedule with Jet Black Stare, Drowning Pool, and Tantric through Nov. 11th (Veteran's Day) in Texas. Saliva will play a halftime NBA homecoming gig at FedEx Forum in Memphis on Halloween, when the Grizzlies host the Magic. CINCO DIABLO is the long-awaited... |
 |
Click Click Boom Saliva (Primary Contributor) |
 |
Back Into Your System by Saliva Saliva frontman Josey Scott unintentionally elevated his band above countless nü metal clones by teaming up with Nickelback's Chad Kroeger to write and record the song "Hero" for the Spider-Man soundtrack. The tang of mainstream success was exactly what the Memphis, Tennessee, group needed to break away from the pack on Back into Your System. This follow-up to its major-label debut, Every Six Seconds, ups the heavy atmospherics and dyspepsia. "Always" takes on the touchy subject of domestic violence with unblinking force as Scott rips into the verses "I've seen the blood all over your hands / Does it make you feel more like a man?," while "Raise Up" mixes testosterone-heavy rapping with raging guitars in the most menacing way possible, and Mötley Crüe bassist Nikki Sixx contributes the... |
 |
Family Reunion Saliva (Primary Contributor) |
 |
Blood Stained Love Story by Saliva For gold-selling Memphis turbo-rockers Saliva, the past couple years of their decade-long career have brought an ocean swell of change. One or more members have had children, stopped drinking, ended longterm relationships, gotten married and/or left the group, and each instance has been accompanied by a new sense of clarity.
As a result, Saliva's fifth album Blood Stained Love Story resounds with a previously untapped level of passion, energy, sincerity and diversity, not to mention an undeniable melodicism that will endear the band to anyone that feels any sort of connection between reality and music.
"I think we've all been through a blood stained love story of one type or another," says frontman Josey Scott. "It's kind of a metaphor for how things can be a... |
|
|
Cinco Diablo Saliva (Primary Contributor) |
 |
Every Six Seconds by Saliva Saliva's heavy rock--with a dash of rap--is at once current and timeless, unlike many of the bands spawned by Korn and Limp Bizkit. This Memphis-bred bunch's powerful, diverse debut features a dozen lyrically and musically focused tracks from a band clearly possessed of strong chops and smart heads. Rangy singer Josey Scott's passionate delivery works well when matched with the chunky riffing of "Musta Been Wrong," the soaring, layered song's intensity balanced by shredding guitar. Every Six Seconds has many such moments, with producer Bob Marlette's taut, techno-inflected touch lending "Lackluster" and "Faultline" a NIN vibe. "Hollywood" is a classic midtempo take on Tinseltown, while the CD's first single, "Your Disease," is simply a hit. "My Goodbyes," the ideal album closer, has a... |
 |
Ladies and Gentlemen Saliva (Primary Contributor) |
 |
Survival of the Sickest by Saliva |
|
|
How Could You? Saliva (Primary Contributor) |
| © 2009 BrightSurf.com |