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New technique in treating patients with liver cancer proves effective
April 14, 2008Use of multipolar radiofrequency ablation in the treatment of colorectal liver metastases is effective and has a relatively low recurrence rate, according to a recent study conducted by researchers at Charité, Campus Benjamin Franklin in Berlin, Germany.
"Radiofrequency ablation (RFA) has become a widely used treatment option for patients with primary liver cancer and liver metastases from some primary tumors, if surgery is not an option. However, because of limited sizes of the ablation zones the technique has been limited to tumors smaller than four centimeters," said Bernd Frericks, MD, lead author of the study. "This long-term study (four years) was performed using a new multipolar radiofrequency (RF)-device allowing for up to six ablation probes to be used simultaneously, thus providing larger ablation zones. We evaluated this new technique prospectively regarding ablation zone size, technical effectiveness, complications and clinical outcome in patients with colorectal liver metastases," he said.
The study evaluated 27 patients with 67 colorectal liver metastases that were treated using multipolar RF ablation. According to the study, complete tumor destruction occurred in 66 of 67 cases. Of the 67 metastases, eight required reablation. After a mean of nine months, 16 patients developed new metastases in the liver and the lung, eight of which were successfully reablated. After four years, 52% of the patients are now tumor-free and 78% are still living.
"Using this new device, the rate of local tumor progressions was not influenced by the size of the tumor to be treated," said Dr. Frericks.
American Roentgen Ray Society
"Using this new device, the rate of local tumor progressions was not influenced by the size of the tumor to be treated," said Dr. Frericks.
American Roentgen Ray Society
Liver Metastases Current Events and Liver Metastases News RSSUnexplained liver hemorrhage after metastasis radiofrequency ablation
Colorectal carcinoma is one of the most common cancers in the world. Approximately one in four of these patients have metastases at diagnosis, liver being the most common site involved.
What relates to the short-term effectiveness of biliary drainage?
Biliary drainage is performed as a palliative treatment of hilar cholangiocarcinoma. The reduction of serum bilirubin is usually the hallmark of successful biliary drainage. However, some patients may have persistent jaundice or scanty bile output after biliary drainage.
Advances in liver surgery enable the prospect of curative treatment for more patients
Although many prognostic factors predicting survival and cancer recurrence in patients undergoing surgery for colorectal liver metastases are already identified, the effects of newly introduced technologies and new drugs in the treatment of these patients are still poorly studied because of the presence of many involved factors.
Surgical treatment provides new option for some colorectal cancer patients
Research out of Wake Forest University School of Medicine suggests that a surgical technique not traditionally used in advanced abdominal cancer may be a viable treatment option for some patients previously thought to be untreatable, offering the real possibility of extending survival for those patients.
A breakthrough in contrast-enhanced intraoperative ultrasonography
The present brief clinical report showed that Contrast-enhanced intraoperative ultrasonography (CE-IOUS) using a new microbubble agent, Sonazoid, can allow surgeons to investigate the whole liver with enough time and to find new metastases intraoperatively.
Experiments could lead to new treatments for neuroblastoma
Neuroblastoma is one of the most devastating diagnoses a child can receive. The cancer's victims average 2 years old when the disease is detected, most often by a parent feeling a lump in a child's abdomen. By then, the disease has often reached an advanced stage, and advanced neuroblastoma kills more than 50 percent of the children in whom it develops, despite aggressive treatment with surgery, chemotherapy and radiation.
New oral angiogenesis inhibitor offers potential nontoxic therapy for a wide range of cancers
The first oral, broad-spectrum angiogenesis inhibitor, specially formulated through nanotechnology, shows promising anticancer results in mice, report researchers from Children's Hospital Boston.
Different type of colon cancer vaccine reduces disease spread, Jefferson scientists show
Taking advantage of the fact that the intestines have a separate immune system from the rest of the body, scientists at the Kimmel Cancer Center at Jefferson in Philadelphia have found a way to immunize mice against the development of metastatic disease.
Interleukin-8, key marker for colorectal cancer treatment
Colorectal cancer (CRC) is currently one of the three most frequent malignancies in Western industrial nations.
Cancer-fighting virus shows promise in early clinical trial
A virus that has been specifically designed by scientists to be safe to normal tissue but deadly to cancer is showing early promise in a preliminary study, researchers said today at the ESMO Conference Lugano (ECLU), Switzerland.
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