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Major surgery no longer needed for the removal of uterine fibroids
April 14, 2008The treatment of uterine fibroids with 3T MR-guided focused ultrasound (MRgFUS) is safe, non-invasive and effective, according to a recent study conducted by researchers at Weill Cornell Medical College in New York, NY.
"Approximately 25% of women in the United States have clinically symptomatic fibroids, and treatment has most commonly been surgical with hysterectomy or myomectomy. However, in the past decade, new options have been developed in radiology, includingnon-invasive MR-guided focused ultrasound (MRgFUS) and minimally invasive uterine artery embolization (UAE) to treat these patients," said Elizabeth K. Arleo, MD, lead author of the study along with Robert J. Min, MD, MBA, chairman of radiology at Weill Cornell Medical College.
The study evaluated 20 patients who had symptomatic leiomyomas and were treated with 3T MRgFUS. These patients had a pelvic MRI and completed a symptom severity score (SSS) of the uterine fibroid symptom and health related quality of life prior to the procedure and at 6 and 12 months after the procedure.
According to the study, at 6 month follow-up, there was a decrease in SSS (ranging between 10-59%), treated fibroid volume, and total uterine volume. At 12 month follow-up, there was a persistent decrease in SSS (ranging between 15-62%), treated myoma volume, and total uterine volume.
"In contrast to having major abdominal surgery with possible removal of their uterus, a patient can have a safe and effective, totally noninvasive procedure in an outpatient setting without the risks of general anesthesia, no ionizing radiation and a much shorter recovery period," said Dr. Arleo. "Patients have returned to work as early as one day after MRgFUS, instead of approximately three days after UAE or six weeks after a myomectomy or hysterectomy," she said.
American Roentgen Ray Society
According to the study, at 6 month follow-up, there was a decrease in SSS (ranging between 10-59%), treated fibroid volume, and total uterine volume. At 12 month follow-up, there was a persistent decrease in SSS (ranging between 15-62%), treated myoma volume, and total uterine volume.
"In contrast to having major abdominal surgery with possible removal of their uterus, a patient can have a safe and effective, totally noninvasive procedure in an outpatient setting without the risks of general anesthesia, no ionizing radiation and a much shorter recovery period," said Dr. Arleo. "Patients have returned to work as early as one day after MRgFUS, instead of approximately three days after UAE or six weeks after a myomectomy or hysterectomy," she said.
American Roentgen Ray Society
Uterine Fibroids Current Events and Uterine Fibroids News RSSMinimally invasive fibroid treatment fares well in multicenter trial
A new multicenter trial found that uterine artery embolization (UAE) is a good alternative to hysterectomy in women with symptomatic fibroids. The findings of the Embolisation versus Hysterectomy (EMMY) Trial appear in the March issue of the journal Radiology.
Focused ultrasound relieves fibroid symptoms in women
A noninvasive ultrasound procedure effectively shrinks uterine fibroids and significantly relieves fibroid-related symptoms in women.
Enhanced MR-guided focused ultrasound guidelines demonstrate improved efficacy and durability
Data released today show that MR-guided focused ultrasound (MRgFUS) is a more effective option for a broader population of uterine fibroid sufferers.
MicroRNAs Can Be Tumor Suppressors
University of Virginia researchers have discovered that microRNAs, a form of genetic material, can function as tumor suppressors in laboratory studies.
MicroRNAs as tumor suppressors
In the May 1st issue of G&D, Drs. Yong Sun Lee and Anindya Dutta (UVA) reveal that microRNAs can function as tumor suppressors in vitro.
Chance of hysterectomy predicted by multi-year study
A woman's chance of undergoing a hysterectomy can now be accurately predicted, according to new UCSF study findings.
Rochester study rolls out RU-486 to treat uterine fibroids
Low doses of the drug mifepristone shrink uterine fibroid tumors and greatly improve the quality of life in women who suffer from pain and heavy bleeding.
Penn researchers start new clinical trial to examine ways to improve treatment of uterine fibroids
Researchers at the University of Pennsylvania School of Medicine are working on ways to improve the results of a non-surgical method to treat fibroids.
Harmful chemicals may reprogram gene response to estrogen
New research shows that exposure to harmful chemicals and drugs during critical developmental periods early in life may actually "reprogram" the way certain genes respond to the female hormone estrogen. This genetic reprogramming may determine whether people with a genetic predisposition for a disease actually develop the disease.
UK researchers develop novel treatment for fibroids
UK researchers have developed a novel method of treating uterine fibroids that allows women to be treated under local anaesthetic as outpatients. Their technique, which uses a laser guided by magnetic resonance imaging (MRI), is reported today (Friday 27 September) in Europe's leading reproductive medicine journal, Human Reproduction.* Around a quarter of women have fibroids - benign fibrous tumours - in their wombs. Many have no symptoms but others suffer heavy or prolonged periods and pain, and sometimes face reproductive problems including infertility or miscarriage. In the UK last year there were 47,000 hysterectomies and 60% involved fibroids. In the USA around 400,000 hysterectomies a
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