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Human vascular system in mice
April 15, 2008The formation of new blood vessels, or angiogenesis, is an Achilles' heel of tumor growth, because tumors depend on the supply of oxygen and nutrients for survival. Therefore, for some years now substances called angiogenesis inhibitors have been used in cancer treatment to suppress this process. In order to advance this new research field, a team of researchers headed by Professor Hellmut Augustin has developed a method to create a complex human vascular system in mice, which stays functional even after several months.
The method is based on the observation that isolated cells of the vessel walls, called endothelial cells, congregate spontaneously in cell cultures to form aggregates known as spheroids. "Individual endothelial cells floating in suspension are doomed to die - the association in spheroids stabilizes them," says Hellmut Augustin. The scientists Abdullah Alajati and Anna Laib have been able to inject such spheroids, embedded in a gel matrix, under the skin of mice and to stimulate the formation of a network of human blood vessels by means of growth factors. The mice were genetically modified in such a way that their immune system was unable to reject the foreign cells. "The newly formed blood vessels are made exclusively of human endothelial cells," explains Anna Laib, a young researcher at the DKFZ. "At the matrix borders the human endothelial cells establish contact with those of the mouse. In this way, the transplanted human vasculature gets connected to the blood circulation of the mouse."
The method provides experimental freedom and may deliver answers to various questions of vascular biology research. Scientists can genetically manipulate the endothelial cells before transplantation in order to investigate the formation of vascular networks. In addition, it is possible to test the effect of pharmacological substances; the Freiburg-based company ProQinase GmbH, which is involved in the study, is already conducting such experiments. "The method is even interesting for the production of artificial tissues," Hellmut Augustin says. "So far, one difficulty with the use of artificial replacement tissues has been to create a functioning vascular system that sufficiently supplies the tissue constructs."
Helmholtz Association of German Research Centres
Helmholtz Association of German Research Centres
Vascular System Current Events and Vascular System News RSSPlay yourself healthy
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Dynamics of the Vascular System (Series on Bioengineering & Biomedical Engineering - Vol. 1) by John K-J Li (Author) Recent advances in vascular biology and vascular engineering have led to the understanding and integration of the two fields. A feature that is fundamental to both is the dynamic aspects of the vascular system. Although the basic principles governing blood flow and the circulatory function are known, new approaches to examining the interaction of different parts of the vascular system have emerged. These include measurement techniques and quantitative methods with greater use of modern technology and computer modeling. An obvious need therefore exists for a book that deals specifically with the dynamics of the vascular system. This book begins with the historical discoveries of the features of the vascular system and its importance in the overall circulatory function. Modern aspects... |
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Vascular System and Viscera Anatomical Chart Laminated by Anatomical Chart Company Classic illustrations by Peter Bachin. Shows system on body. Illustrates heart (right anterior, left anterior, and posterior views), heart in systole, female pelvis, base of the brain, and branches of abdominal aorta and portal vein. |
![Saunders Physical Examination & Health Assessment: Cardiovascular System: Peripheral Vascular System And Lymphatic System Video [VHS]](http://ecx.images-amazon.com/images/I/51%2BTD4c70PL._SL160_.jpg) |
Saunders Physical Examination & Health Assessment: Cardiovascular System: Peripheral Vascular System And Lymphatic System Video [VHS] Starring: Saunders |
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Vascular System of the Body Giclee Poster Print by Andreas Vesalius, 18x24 by AllPosters.com Vascular System of the Body is a limited edition fine art giclee print, which uses a specialized printer to deliver a fine stream of ink onto archival paper. It results in museum-quality art of incredibly vivid color, depth and resolution that captures the essence of the artist's intent. You're sure to find that perfect piece to matches your style and buget from this collection of fine art prints. |
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Anatomical Chart Company Vascular System And Viscera Chart by Anatomical Chart Company Classic illustrations by Peter Bachin. Shows system on body. Illustrates heart (right anterior, left anterior, and posterior views), heart in systole, female pelvis, base of the brain, and branches of abdominal aorta and portal vein. Size: 20" W x 26" L |
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Classic Blood & Heart Films DVD: 1930s - 1950s Blood Tests, The Heart, Circulation & Cardiovascular System History Pictures Films Also With: Inc./A.J Carlson ERPI Classroom Films (Producer), Almanac Films/Paul F Moss/Thelma Schnee (Producer) This compilation features films about blood, the circulatory system and the heart. These vintage films are full of bizarre experiments based on quirky science. Table Of Contents: (1) Precipitins (1930) - A bizarre silent film that does experiments comparing the blood of rabbits and sheep the blood of humans - 8 Minutes (2) Heart and Circulation (1937) - A vivid film about the importance of the heart to human body that uses real footage of animal and human hearts as well as animation, to educate the audience. Contains graphic footage of open chest cavities and pumping hearts - 10 Minutes (3) The Heart (1950) - A stylish film that explores the workings of the heart and how humans can protect their heart from disease and failure. Is full of interesting tips, like warming up before running,... |
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Vascular System and Viscera Anatomical Chart by Anatomical Chart Company (Editor) Classic illustrations by Peter Bachin. Shows system on body. Illustrates heart (right anterior, left anterior, and posterior views), heart in systole, female pelvis, base of the brain, and branches of abdominal aorta and portal vein. |
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Planetary Herbals Full Spectrum Horse Chestnut, 300 mg, Tablets, 120 tablets (Pack of 2) by Planetary Formulas Herbal supplement. 20% Acescin. Supports the integrity of the veins and capillaries. Formulated by Michael Tierra L.Ac, O.M.D. Almost unknown in America, horse chestnut is a staple of European herbalism. Horse chestnut is rich in saponins and flavones, w |
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Chart - The Vascular System and Viscera by Anatomical Chart Company LFA #98952 Chart - The Vascular System and Viscera. All LFA Charts and Posters are designed to a) Provide just the right level of detail, b) At-a-glance format, c) Striking colorful images, d) Enlarged view of key organs or structures, e) Comprehensive and anatomically/medically accurate. Plastic laminate, 20" x 26" offers flexibility, durability and attractive appearance for medical professionals, patients, students and other specialists. Complete with metal eyelets at top corners for hanging or portable stand display. "Write-on, wipe-off" surface is perfect for classrooms and professional offices. Note: This is a durable plastic laminated wallchart- not simply paper as with other sellers. Washable. Designed to last for many years of use. Shipped in mailing tube. Note: Many charts... |
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The Vascular System 3D Raised Relief Chart by Anatomical Chart Company |
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