 |
|
Drug compound leads to death of ovarian cancer cells resistant to chemotherapy
April 18, 2008In a discovery that may be useful for maintaining remission in chemo-resistant ovarian cancer, Yale scientists report that pre-clinical studies have shown the drug compound NV-128 can induce the death of ovarian cancer cells by halting the activation of a protein pathway called mTOR.
Gil Mor, M.D., associate professor in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale School of Medicine, and associate research scientist Ayesha Alvero, M.D. presented the data April 15 during an oral presentation at the annual meeting of the American Association for Cancer Research.
NV-128, developed by Novogen Limited, holds promise as a more targeted therapy for ovarian cancer because it works differently from traditional therapies that are dependent on enzymes known as caspases to trigger cell death. Therapies using caspases to kill cancer cells can be ineffective in chemo-resistant cancer cells due to mutations that short-circuit signals that trigger cancer cell death.
"We consider that the capacity of NV-128 to trigger caspase-independent cell death, in otherwise chemoresistant ovarian cancer cells, opens new possibilities for the use of NV-128 as a potential addition to conventional chemotherapy targeting ovarian cancer cells," said Mor.
In the context of developing therapies for late stage ovarian cancer, Mor said, the finding may be "a key step to the development of alternative targeted therapy for patients with cancer recurrence."
Yale University
Ovarian Cancer Current Events and Ovarian Cancer News RSSFDA approved leukemia drugs shows promise in ovarian cancer cells
The drug Sprycel, approved for use by the U.S. Food and Drug Administration in patients with chronic myeloid leukemia, significantly inhibited the growth and invasiveness of ovarian cancer cells and also promoted their death, a study by researchers with UCLA's Jonsson Comprehensive Cancer Center found.
American Dietetic Association Releases Updated Position Paper Promoting and Supporting Breastfeeding
The American Dietetic Association has released an updated position paper on breastfeeding that details health benefits for both infants and mothers and encourages promotion of breastfeeding whenever possible.
Metals could forge new cancer drug
Drugs made using unusual metals could form an effective treatment against colon and ovarian cancer, including cancerous cells that have developed immunity to other drugs, according to research at the University of Warwick and the University of Leeds.
Breast cancer patients with high risk gene diagnosed 6 years earlier than generation before
Women with a deleterious gene mutation are diagnosed with breast cancer six years earlier than relatives of the previous generation who also had the disease and/or ovarian cancer, according to new research from The University of Texas M. D. Anderson Cancer Center.
Cancer Predisposition From Gene Variant Shows Strong Gender Bias
Cancer predisposition resulting from the presence of a specific gene variant shows a strong gender bias, researchers at the University of Cincinnati (UC) have demonstrated.
Medications Effective in Reducing Risks for Breast Cancer Can Also Cause Serious Side Effects
Three drugs that reduce a woman's chance of getting breast cancer also have been shown to cause adverse effects, according to a new report from the Agency for Healthcare Research and Quality (AHRQ), U.S. Department of Health & Human Services.
Scientists from University of Hawaii at Manoa find genetic marker
A new genetic marker associated with ovarian cancer risk was recently discovered by an international research group, led by scientists from the Cancer Research Genetic Epidemiology Unit in the United Kingdom.
New treatment in sight for ovarian cancer
In the future, women with metastatic ovarian cancer could be treated with a radioactive substance that can seek and destroy tumour cells.
Young early stage ovarian cancer patients can preserve fertility
A new study finds that young women with early-stage ovarian cancer can preserve future fertility by keeping at least one ovary or the uterus without increasing the risk of dying from the disease.
Estrogen-Dependent Switch Tempers Killing Activity of Immune Cells
The sex hormone estrogen tempers the killing activity of a specific group of immune cells, the cytotoxic T cells (CTLs), which are known to attack tumor cells and cells infected by viruses.
More Ovarian Cancer Current Events and Ovarian Cancer News Articles
 |
Beating Ovarian Cancer: How To Overcome The Odds And Reclaim Your Life by Chris Bledy (Author) A diagnosis of Ovarian Cancer does not have to be a death sentence. Recent advances in medicine have made this once incurable disease treatable and manageable. You can beat advanced and even recurring, ovarian cancer. Simple but significant lifestyle changes can produce big results when it comes to healing. |
 |
Ovarian Cancer Awareness "Unite to Fight" Wristband Adult Size by sci Ovarian Cancer Awareness "Unite To Fight" Wristband adult size |
 |
Ovarian Cancer Awareness 8" Ribbon Car Magnet by sci Ovarian Cancer Awareness 8" Ribbon Car Magnet |
 |
A Guide to Survivorship for Women with Ovarian Cancer (A Johns Hopkins Press Health Book) by F. J. Montz MD KM FACOG FACS (Author), Robert E. Bristow MD FACOG (Author), Paula J. Anastasia RN MN OCN (Assistant) This comprehensive guide to ovarian cancer offers a wealth of information to ease the physical, emotional, and psychic suffering of women with the disease. The authors -- two Johns Hopkins gynecologic oncologists and a gynecologic-oncology clinical nurse -- put particular emphasis on the concept of "survivorship," or living life well in the face of daunting uncertainties. They stress the importance of self-determination: the right of each patient to be informed, involved, and in control of her care. Up-to-date information on diagnosis and treatment, including surgery, chemotherapy, radiation, pain management, and alternative therapies, forms the core of the book. But the authors' immense clinical experience also means they understand what women worry about and care about, and... |
 |
L'Oréal Paris Color of Hope OCRF (Ovarian Cancer Research Fund) Fundraising Sterling Silver Pavé CZ Bracelet by Netaya Sterling beauty with an equally beautiful message. Its new, its exclusive and its absolutely beautiful. LOreal Paris is proud to present the Color of Hope Bracelet, a fundraising campaign, with 100% of all net profits ($5.00 per bracelet) benefiting The Ovarian Cancer Research Fund (OCRF). Whether viewed as a circle representing life, endurance, love or seen as an "O" for ovarian cancer, the bracelet is a simple way for women everywhere to visibly and tangibly help in the fight against one of the world's most deadly of women's cancers. The exclusive sterling silver Color of Hope bracelet features a rolo design chain with an "O" toggle clasp, adorned with pave cubic zirconias to give a beautiful brilliance. And to ensure that all women can adorn their wrists, the bracelet... |
 |
Ovarian Cancer Journeys: Survivors Share Their Stories To Help Others by Ayala Miron (Author) "All of the research has reinforced that ovarian cancer is not a silent disease as was once thought and as is shown quite eloquently in this collection of stories.... The value of this collection of stories is that it helps raise awareness about symptoms, need for patient persistence, and the importance of being treated by a gynecologic oncologist." Barbara A. Goff, MD Professor and Co-Director, Division of Gynecologic Oncology University of Washington School of Medicine Women of ages 17 to 78 join to tell their true stories. Find out about the lessons they have learned along their ovarian cancer journeys; from symptoms to diagnosis, trough treatments, and survival. Ovarian cancer facts: Occurs in 1 out of 57 women 89% have symptoms at the early stages... |
 |
Ovarian Cancer Awareness Teal Ribbon Crystal Heart Necklace by CharmingChick This is a beautiful new teal ribbon heart charm necklace that is the perfect way to show your support for Ovarian Cancer Awareness. The pendant measures about 5/8 of an inch tall and is made of genuine sterling silver. It has stunning teal Swarovski Crystal embedded in the front. Box chain measures about 16 inches long. This teal ribbon necklace would make a great gift or is a wonderful way to remember a loved one with Ovarian Cancer. |
 |
100 Questions & Answers About Ovarian Cancer, Second Edition by Don S. Dizon (Author) Whether you're a newly diagnosed ovarian cancer patient, a survivor, or a friend or relative of either, this book offers help. Completely updated, the new second edition of 100 Questions & Answers About Ovarian Cancer gives you authoritative, practical answers to your questions about treatment options, post-treatment quality of life, sources of support, and much more. Written by a gynecologic oncologist and a gynecologic surgeon, with actual patient commentary, this book is an invaluable resource for anyone coping with the physical and emotional turmoil of this frightening disease. |
 |
100 Pack Teal Blue Ribbon Temporary Tattoos for Ovarian Cervical Uterine Cancer Awareness by Palmetto Fundraising Show your courage and support! These teal ribbon tattoos are perfect for your next awareness event. These tattoos make great inspirational giveaways. 100 tattoos per package. Teal ribbon design with clear sides. Approximately 1.5" x 2". These cancer awareness favors are perfect for your awareness fundraisers or event. |
 |
L'Oreal Paris Hope Necklace by Netaya The L'Oreal Paris Hope Necklace is a simple way for women everywhere to visibly and tangibly help in the fight against one of the most deadly women's cancers. The necklace was designed by 2008 Swarovski Award for Accessory Design recipient Philip Crangi and features a double eternity ring design of cubic zirconia set in sterling silver. One ring is worn for remembrance and one ring is worn as a symbol of hope for the future. The two eternity rings are free floating and suspended from an 18" rolo link chain. Each ring is comprised of 21 channel set, 2mm brilliant cubic zirconias. This necklace normally retails for $99 but is being offered for only $29.95 (plus $5.95 s&h) to support ongoing research to defeat this dreadful disease. Net profits (five dollars per sale) will benefit... |
| © 2009 BrightSurf.com |