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Gastric juice for diagnosis of H. pylori infection in patients on proton pump inhibitors
April 30, 2008This study determined the efficiency of a gastric juice PCR test for the detection of H. pylori infection in patients receiving PPI therapy and compared it with histology and gastric biopsy PCR.
This study, led by Dr Javed Yakoob, is described in a research article to be published in the March 14, 2008, issue of the World Journal of Gastroenterology.
Helicobacter pylori (H pylori) is a gram-negative spiral bacterium that infects the human gastric mucosa and is associated with gastritis, gastroduodenal ulcer disease, gastric carcinoma, and lymphoma of mucosa-associated lymphoid tissue.
An accurate diagnosis of H pylori infection is important when seeking to cure patients with persistent gastric symptoms in which H pylori infection is suspected. In patients on acid-reducing drugs such as PPI or H2-receptor blockers (H2RB), the accuracy of the rapid urease test, urea breath test and histology are known to be lower for the diagnosis of H pylori infection.
In the view of the authors, the development of new targets to test for H pylori infection in patients with prior use of acid-reducing drugs is important, considering the morbidity and mortality associated with this infection. Gastric juice PCR has been evaluated as a highly specific and rapid method for the detection of H pylori.
Using an original design, this study represents a real and valuable advance in the methodology of diagnosis in this field. This research was performed by doctors with the Department of Microbiology and Pathology, Faculty of Health Sciences, at Aga Khan University in Karachi, Pakistan. The study was funded by the Aga Khan University Research Committee.
World Journal of Gastroenterology
An accurate diagnosis of H pylori infection is important when seeking to cure patients with persistent gastric symptoms in which H pylori infection is suspected. In patients on acid-reducing drugs such as PPI or H2-receptor blockers (H2RB), the accuracy of the rapid urease test, urea breath test and histology are known to be lower for the diagnosis of H pylori infection.
In the view of the authors, the development of new targets to test for H pylori infection in patients with prior use of acid-reducing drugs is important, considering the morbidity and mortality associated with this infection. Gastric juice PCR has been evaluated as a highly specific and rapid method for the detection of H pylori.
Using an original design, this study represents a real and valuable advance in the methodology of diagnosis in this field. This research was performed by doctors with the Department of Microbiology and Pathology, Faculty of Health Sciences, at Aga Khan University in Karachi, Pakistan. The study was funded by the Aga Khan University Research Committee.
World Journal of Gastroenterology
Pylori Infection Current Events and Pylori Infection News RSSIs short-term Celecoxib intervention a effective method for preventing gastric carcinogenesis?
Since the isolation and culture of Helicobacter pylori (H. pylori) in 1983, this bacterium has become accepted as an important human pathogen for the development of gastritis, peptic ulcer, and gastric cancer.
A new explanation of 'Asian paradox'
Although Helicobacter pylori (H. pylori) has been classified as a class I (or definite) carcinogen by World Health Organization (WHO), the controversy as to why only a minority of infected patients develop gastric cancer still remains.
Protein interaction network can respond Helicobacter pylori infection?
Helicobacter pylori (H pylori) is a gram negative bacterium which infects about 50% of the world population. H pylori colonization causes a strong systemic immune response.
Uncovering the secrets of ulcer-causing bacteria
A team of researchers from Boston University, Harvard Medical School and Massachusetts Institute of Technology recently made a discovery that changes a long held paradigm about how bacteria move through soft gels.
How to confirm the causes of iron deficiency anemia in young women
Iron-deficiency anaemia (IDA) is commonly seen in women aged <50 years. The diagnostic workflow in young women affected by IDA is not clearly established.
Glutamine supplements show promise in treating stomach ulcers
Nearly 20 years ago, it was discovered that bacteria known as Helicobacter pylori were responsible for stomach ulcers.
Broccoli sprouts may prevent stomach cancer by defeating Helicobacter pylori
Three-day-old broccoli sprouts, a widely available human food, suppressed Helicobacter pylori (H. pylori) infections, according to a report in Cancer Prevention Research, a journal of the American Association for Cancer Research. H. pylori infections are one of the most common bacterial infections worldwide and are a major cause of stomach cancer.
Clinical trial backs use of special yogurt to fight stomach ulcer bacteria
Results of the first human clinical studies confirm that a new yogurt fights the bacteria that cause gastritis and stomach ulcers with what researchers describe as almost vaccine-like effects, scientists in Japan will report here today at the 237th National Meeting of the American Chemical Society.
Why are tribal populations free from clinical symptoms infection with H pylori strains?
Helicobacter pylori is of growing concern today because of its crucial role in the pathogenesis of chronic gastritis, peptic ulcer diseases and in the multi-step carcinogenic process of gastric cancer. However, it is still an enigma why few strains are associated with ulcer formation with relevant clinical symptoms while others are not associated with any disease manifestation.
Is it effective of low-dose furazolidone-based quadruple regimens for H pylori infection?
H pylori infection was associated with many upper gastrointestinal diseases. The prevalence of H pylori resistant to antibiotics was increased with the spreading of H pylori eradication.
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