Science News & Science Current Events
 
Email a Friend Send to a friend
Printer Friendly Print Phase of clock gene expression in human leukocytes correlates with habitual sleep timing

Phase of clock gene expression in human leukocytes correlates with habitual sleep timing

May 01, 2008

WESTCHESTER, Ill. - The phase of clock gene expression in leukocytes, assessed in the absence of the masking effects of light-dark and sleep-wake cycles, correlates with habitual sleep timing, according to a study published in the May 1 issue of the journal SLEEP.

The study, authored by Simon N. Archer, PhD, of the University of Surrey in Guildford, England, and colleagues, focused on 24 healthy subjects in a home environment and clinical research center setting. Blood sampling was provided every hour during an approximate 40-hour constant routine in the absence of a sleep-wake cycle. Actigraphy and sleep diaries were used to characterize sleep timing.




"We have very accurately measured the circadian oscillations in genetic markers of a peripheral circadian clock in human leukocytes," said Dr. Archer. "We have done this in controlled, constant routine conditions in the absence of masking sleep/wake activity. We have shown significant correlations between the oscillations of these clock genes and hormone rhythms and sleep/wake cycles within individuals. Moreover, we have compared individuals with differences in the clock gene PER3, and find that these individuals also show differences in these correlations. This study is important because it shows for the first time that the timing of a human peripheral clock correlates with hormonal circadian markers and sleep/wake activity. It also shows that a polymorphism within a clock gene can affect these timing correlations."

Experts recommend that adults get between seven and eight hours of nightly sleep.

The American Academy of Sleep Medicine (AASM) offers the following tips on how to get a good night's sleep:

* Follow a consistent bedtime routine.

* Establish a relaxing setting at bedtime.

* Get a full night's sleep every night.

* Avoid foods or drinks that contain caffeine, as well as any medicine that has a stimulant, prior to bedtime.

* Do not bring your worries to bed with you.

* Do not go to bed hungry, but don't eat a big meal before bedtime either.

* Avoid any rigorous exercise within six hours of your bedtime.

* Make your bedroom quiet, dark and a little bit cool.

* Get up at the same time every morning.

Those who suspect that they might be suffering from a sleep disorder are encouraged to consult with their primary care physician or a sleep specialist.

American Academy of Sleep Medicine



Related Leukocytes Current Events and Leukocytes News Articles Leukocytes Current Events and Leukocytes News RSS Leukocytes Current Events and Leukocytes News RSS
New therapeutic options for diabetes-related tissue injury
Diabetes mellitus is a metabolic disorder characterized by altered glucose tolerance and impaired lipid and carbohydrate metabolism, and is associated with a number of complications directly resulting from hyperglycemiainduced inflammation.

A single mechanism for hypertension, insulin resistance and immune suppression
Many of the 75 million Americans with essential hypertension also develop diabetes and other complications in addition to their high blood pressure, and researchers have discovered a common molecular mechanism in a strain of rat that explains why such metabolic disorders arise together in mammals.

NEJM editorial on significance and limitations of new lupus gene expression research
Some 1.5 million Americans, most of them women, suffer from lupus, a disease where the person's immune system attacks the body's own tissue.

Blood stem cells fight invaders, study finds
No other stem cell is more thoroughly understood than the blood, or hematopoietic, stem cell.

Atypical pathogen treatment vital in hospitalized CAP patients
Hospitalized patients with community-acquired pneumonia (CAP) who received treatment regimens against atypical disease-causing pathogens reached clinical stability quicker, had fewer days of hospitalization, and had lower mortality rates as a result of their disease, according to a large new study.

Novel transfusion strategy for pediatric patients in intensive care
In its April 19th, 2007 edition, the New England Journal of Medicine published an article about the findings of a multi-center randomized clinical trial that compared transfusion strategies for patients in pediatric intensive care units.

Blame the brain for high blood pressure
The controversial idea that one cause of high blood pressure lies within the brain, and not the heart or blood vessels, has been put forward by scientists at the University of Bristol, UK, and is published this week in the journal Hypertension.

Infection detectives use disease 'fingerprints' to track common infections in children
Infectious disease specialists at UT Southwestern Medical Center have found a new method for identifying suspect viruses and bacteria that cause some of the most common acute infections in children.

Antibody signal may redirect inflammation to fuel cancer
As evidence mounts that the body's normally protective inflammation response can drive some precancerous tissues to become fully malignant, UCSF scientists report discovering an apparent trigger to this potentially deadly process.

Regular, moderate exercise reduces the risk of colds in postmenopausal women
Postmenopausal women who want to decrease their risk of colds would be well advised to dust off their sneakers and get moving, suggests a new study led by researchers at Fred Hutchinson Cancer Research Center.
More Leukocytes Current Events and Leukocytes News Articles


Leukocyte and Stromal Cell Molecules: The CD Markers
by Heddy Zola, Bernadette Swart, Ian Nicholson, Elena Voss

This unique reference summarizes the structure and function of nearly 600 known leukocyte cell surface molecules and their potential utility as diagnostic and therapeutic targets.  Leukocyte and Stromal Cell Molecules: The CD Markers offers comprehensive coverage of all known CD molecules based on the results of the latest Human Leukocyte Differentiation Antigen (HLDA) Workshops. It...

Physiology and Pathophysiology of Leukocyte Adhesion

Leukocytes play an integral role in the pathogenesis of different inflammatory disorders. Recent results indicate that leukocytes are also involved in conditions that had not formerly been associated with a cytotoxic effect by leukocytes. In 27 chapters by leading investigators, this book reviews recent research on leukocyte adhesion and microvascular kinetics. Detailed descriptions of adhesive...

Assessment of Immune Status by the Leukocyte Adherence Inhibition Test

Gale Encyclopedia of Nursing and Allied Health: Human leukocyte antigen test
by Mark A. Best

The article is excerpted from Gale Encyclopedia of Nursing and Allied Health. This 5-vol. set provides more than 850 entries covering topics in nursing and allied health written for students and professionals in the field. Alphabetically arranged entries cover topics in body systems and functions, conditions and common diseases, issues and theories, techniques and practices, and devices and...

Genetic control of host resistance to infection and malignancy: Proceedings of an international symposium held in Montreal, May 12-16, 1985 (Progress in leukocyte biology)

Leukocyte-Depleted Blood Products (Current Studies in Hematology and Blood Transfusion)
by T. A. Lane

Leukocyte Function
by Martin Cline



Leukocyte Depletion in Cardiac Surgery and Cardiology

Controversies of Leukocyte Poor Blood
by Leo J. McCarthy

Induction of lesional and circulating leukocyte apoptosis by infliximab in a patient with moderate to severe psoriasis.(CASE REPORTS): An article from: Journal of Drugs in Dermatology
by Rama Malaviya, Yvonne Sun, Jennifer K. Tan, Melissa Magliocco, Alice B. Gottlieb

This digital document is an article from Journal of Drugs in Dermatology, published by Thomson Gale on October 1, 2006. The length of the article is 1776 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.Citation...

© 2008 BrightSurf.com