 |
|
New Cancer Gene Discovered
May 09, 2008Oklahoma City, OK -- Researchers at the OU Cancer Institute have identified a new gene that causes cancer. The ground-breaking research appears Monday in Nature's cancer journal Oncogene.
The gene and its protein, both called RBM3, are vital for cell division in normal cells. In cancers, low oxygen levels in the tumors cause the amount of this protein to go up dramatically. This causes cancer cells to divide uncontrollably, leading to increased tumor formation.
"We are excited about this discovery because most cancers are thought to come from mutations in genes, and our studies, for the first time, have shown that too much of this type of protein actually causes normal cells to turn into cancer cells," said Shrikant Anant, Ph.D., a cancer biologist at the OU Cancer Institute and principal investigator on the project.
Anant said they found RBM3 protein in every stage of many cancers, and the amount of protein increased as the cancer grew. The protein helped the cancer grow faster, avoid cell death and was part of the process that formed new blood vessels to feed the tumor.
"This process, called angiogenesis, is essential for tumor growth and suggests that targeting RBM3 may be an extremely powerful tool against many and perhaps all solid tumors," Anant said.
A quarter of the funding for the cancer research comes from an $800,000 grant from the National Institutes of Health with remaining funds from the University of Oklahoma College of Medicine. The next step for Anant, Dr. Courtney Houchen and their research team at the OU Health Sciences Center is to develop agents that block the protein function in a variety of cancers. Researchers expect to start clinical trials at OU in about five years.
University of Oklahoma
Science News and Science Current Events Tag Cloud
This tag cloud is a visual representation of term frequencies of random science news topics with common terms grouped together and emphasized by their display size.
Cancer Gene Current Events and Cancer Gene News RSSWet ear wax and unpleasant body odors signal breast cancer risk
If having malodorous armpits (called osmidrosis) and goopy earwax isn't bad enough, a discovery by Japanese scientists may add a more serious problem for women facing these cosmetic calamities.
Gene signature helps predict breast cancer prognosis
Vanderbilt-Ingram Cancer Center researchers have uncovered a gene signature that may help predict clinical outcomes in certain types of breast cancer.
Reversing effects of altered enzyme may fight brain tumor growth
An international team of scientists from the Moores Cancer Center at the University of California, San Diego, the University of North Carolina and several institutions in China have explained how a gene alteration can lead to the development of a type of brain cancer, and they have identified a compound that could staunch the cancer's growth.
Breakthrough model for human cancer may improve development of cancer drugs; study in PNAS
AVEO Pharmaceuticals, Inc., a biopharmaceutical company leveraging breakthrough discoveries in cancer biology to discover, develop and commercialize targeted oncology therapies, today announced findings from its novel human-in-mouse (HIM) cancer model system, in which AVEO successfully created invasive human tumors from primary human breast tissue that develop over time in mice and mimic human tumor behaviors and response.
Getting down to cancer basics
Researchers have identified a new cancer gene - one that is common to many cancers and affects the most basic regulation of our genes. The new example - a gene on the X chromosome called UTX - is found in 10% of cases of multiple myeloma and 8% of esophageal cancers.
Science teams at Cold Spring Harbor Laboratory identify 13 new tumor-suppressor genes in liver cancer
Over the years, hunting for cancer-related genes and understanding how they work has been an important, although time-consuming, exercise. At Cold Spring Harbor Laboratory (CSHL), five different research groups have now combined their expertise to speed up the rate of discovering cancer-related genes and validating their function in living animals.
Fish cancer gene linked to pigment pattern that attracts mates
Though skin cancer is deadly to male fish, it also has one perk: The black melanoma splotches arise from attractive natural markings that lure female mates. A new study published in the Proceedings of the National Academy of Sciences this week shows that the melanoma gene can be conserved in swordtail fish because of its beneficial role in sexual selection.
Cancer signatures uncovered
A new systematic analysis of the relationship between the neoplastic and developmental transcriptome provides an outline of trends in cancer gene expression.
Recipe for cell reprogramming adds protein
A drug-like molecule called Wnt can be substituted for the cancer gene c-Myc, one of four genes added to adult cells to reprogram them to an embryonic-stem-cell-like state.
Protein thought to promote cancer instead functions as a tumor suppressor, researchers report
A protein previously thought to promote colorectal cancer instead suppresses the growth of human cancer cells in culture, researchers at UT Southwestern Medical Center have found.
More Cancer Gene Current Events and Cancer Gene News Articles
 |
An Intimate Relationship: Genes, Cancer, Lifestyle, and You by Charles H Chen (Author) Cancer is one of the most devastating diseases in the world today, but early prevention remains the key to controlling it. Charles H. Chen shows that through a strict regime of diet, exercise, and other healthy lifestyle changes, you can increase your chances of keeping cancer from your doorstep. Diagnosed with colon cancer in 1998, Chen decided to tackle the disease head on and was determined to learn the causes of cancer, the treatments, and prevention methods. Chen brings a unique perspective to this subject as both a medical doctor and a cancer survivor, breaking down the various aspects of this worldwide epidemic. Practical and concise, An Intimate Relationship covers topics such as: Screenings for men and women Benefits of early diagnosis Treatment options ... |
 |
Genes and Disease - Cancers by www.MustyOldBooks.com A short overview of genes and disease. This article looks at various cancers. |
 |
ABC News Nightline The "Breast Cancer Gene"/Neo-Nazism Spreading/Deeper Vocals The women in the Davis family have been plagued by breast cancer for three generations. Jennifer Davis decided to utilize new genetic tests to determine if the current generation will suffer from the killer as well. If they test positive, they have an 87% chance of developing breast cancer. What measures are they willing to take try to prevent the disease? Neo-Nazism and its members are using the Internet to draw recruits to their violent cause in Russia. Russian skinheads, who may be responsible for the deaths of about 50 individuals, film themselves beating up the immigrants that are flooding the post-Soviet nation. For women who swooned at the sight of sex symbol Barry White, it turns out it wasn't love, it was science. Correspondents: John Donvan, Dan Harris and Nick Watt ... |
 |
Laugh and Learn About Breastfeeding Starring: Sheri Bayles Directed By: Gene Cernilli Although Breastfeeding is a natural process, it is mostly a learned art. Obstacles are the norm, but it is the best start that a mother can give her new baby. Breastfeeding benefits both mothers and babies, it protects babies from disease, and women who have nursed have substantially lower rates of breast cancer. Like the other two video classes in this series, 'Laugh and Learn About Childbirth' and 'Laugh and Learn About Newborn Baby Care', 'Laugh and Learn About Breastfeeding' is a comprehensive, fun and entertaining way to learn everything you need to know to have a pleasant Breastfeeding experience. On her new DVD, Sheri Bayles, RN shares her experiences, gives tips and strategies to avoid Breastfeeding obstacles, explains latch on, holds and positions, especially for breastfeeding... |
|
SciEd In Search of the Cancer Gene; For 6 Gels (5 lanes each) with InstaStain Methylene Blue by Edvotek Classroom Kit, In Search of the Cancer Gene; Edvotek; For 6 Gels (5 lanes each) with InstaStain Methylene Blue | |
|
Cancer Therapy by Intl Soc Gene Therapy Mole Bio | |
 |
Breakthrough: The Race to Find the Breast Cancer Gene by Kevin Davies (Author), Michael White (Author) September 1994. "The most impassioned and publicly visible of all genetic races" (The New York Times) comes to a triumphant close with the discovery of BRCA1, popularly known as the breast cancer gene. The result of a four-year international effort involving scientists from the United States, Canada, England, France, and Japan, among others, it is hailed as one of the most significant discoveries in recent medical science. Breakthrough is the brilliant account of this historic undertaking, its origins and development, and its implications for the future. With vivid profiles of the people and politics behind the events, Kevin Davies and Michael White unfold a scientific detective story that offers a rare glimpse into the complex—and fiercely competitive—world of genetic... |
 |
Genes, Development and Cancer: The Life and Work of Edward B. Lewis by Howard D. Lipshitz (Editor) Edward B. Lewis' science is the bridge linking experimental genetics as conducted in the first half of the twentieth century, and the powerful molecular genetic approaches that revolutionized the field in its last quarter. His Nobel Prize winning studies founded the field of developmental genetics and laid the groundwork for our current understanding of the universal, evolutionarily conserved strategies controlling animal development. A lesser-known aspect of Lewis' canon is the pioneering studies he carried out on ionizing radiation and human cancer. In doing so, he was propelled into a public storm over nuclear weapons testing policy. For the first time Lewis' key publications in the fields of genetics, developmental biology, radiation and cancer are compiled within one... |
 |
Benign Prostatic Hyperplasia AHCPR Clinical Practice Guideline/Tumor Suppressor Genes in Human Cancer (NCME Video 658) Also With: Network For Continuing Medical Education (Primary Contributor), John Wasson (Primary Contributor), Daniel A Haber (Primary Contributor) In February, 1994, the Agency for Health Care Policy and Research (AHCPR) released a clinical practice guideline dealing with the diagnosis and treatment of benign prostatic hyperplasia. This telecourse presents highlights of that guideline. In the 1980's, the study of positive oncogenes was a major focus in the quest to understand the molecular origins of cancer. Today, tumor suppressor genes are sharing the spotlight and may exemplify an untapped resource for anticancer therapy. Dr. Haber demonstrates how recessive oncogenes, which normally control cell growth, allows cells to progress to malignancy when lost or inactivated. |
 |
Genes, Development and Cancer: The Life and Work of Edward B. Lewis by Springer Edward B. Lewis' science is the bridge linking experimental genetics as conducted in the first half of the twentieth century, and the powerful molecular genetic approaches that revolutionized the field in its last quarter. His Nobel Prize winning studies founded the field of developmental genetics and laid the groundwork for our current understanding of the universal, evolutionarily conserved strategies controlling animal development. A lesser-known aspect of Lewis' canon is the pioneering studies he carried out on ionizing radiation and human cancer. In doing so, he was propelled into a public storm over nuclear weapons testing policy. For the first time Lewis' key publications in the fields of genetics, developmental biology, radiation and cancer are compiled within one... |
| © 2009 BrightSurf.com |