Research shows timing improves cleft palate surgeryMay 13, 2008Findings change the way doctors perform surgery Research by Dr. Damir Matic, a scientist with Lawson Health Research Institute in London, Ontario is changing the way cleft palate surgeries are performed throughout North America and around the world. Matic has been conducting research to determine the optimal time to close the gum tissue of cleft palate patients. His research suggests that it is best to wait until the child is older. Matic is a craniofacial/plastic surgeon at London Health Sciences Centre and a professor in the department of surgery at the Schulich School of Medicine & Dentistry at The University of Western Ontario. Surgical timing has been a controversial topic with various cleft centers around the world opting for early closure at about 3-6 months of age. However, Matic, using research complied over the past 20 years has shown that the best time to close the cleft at the alveolus (gum) in patients with either one or two sided clefts is at eight or nine years of age prior to canine tooth eruption. "We close the lip at three months of age, we close the palate at one year old, but we don't touch the gum until they are eight or nine, a time that corresponds to when the adult teeth start to appear," Matic says. The study represents a significant breakthrough in cleft research involving an unprecedented sample size of 136 children. Matic and his team were able to look at a large group of children who had the cleft repair performed early, and then compare the group to a large group of children who had the repair performed when they were older. "Cleft is the most common facial anomaly and the second most common congenital anomaly among children," Matic adds. "Our research is clinically based in terms of looking at how we can make our repairs better in light of our current knowledge and past discoveries. Based on our data, the down-side of early closure is much worse than any potential benefits, and repairing the cleft prior to this time (7-9 years) will damage facial growth." Part one and two of the study looked at bone production and facial growth in unilateral clefts and was presented in 2006 and 2007 to the American Cleft Palate Association (ACPA), the largest society dedicated to cleft research in the world. Matic's research won best paper in the Junior Investigator Competition out of hundreds of submissions from around the world. Part three of the study looked at how the repair affects bone production and facial growth in patients with bilateral clefts. These findings were presented at the ACPA meeting in Philadelphia last month. At this meeting, Matic was involved in a panel discussion/debate regarding his research where he recommended the later closure. The overall majority of the participants voted with Matic, leading to a change in recommendation in the way cleft palates will be treated in hospitals around the world. University of Western Ontario |
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| Related Cleft Palate Current Events and Cleft Palate News Articles In rare disease, a familiar protein disrupts gene function An international team of scientists studying a rare genetic disease discovered that a bundle of proteins with the long-established function of keeping chromosomes together also plays an important role in regulating genes in humans. Scientists discover why teeth form in a single row A system of opposing genetic forces determines why mammals develop a single row of teeth, while sharks sport several, according to a study published today in the journal Science. When completely understood, the genetic program described in the study may help guide efforts to re-grow missing teeth and prevent cleft palate, one of the most common birth defects. Advancement in tissue engineering promotes oral wound healing Oral tissue engineering for transplantation to aid wound healing in mouth (oral cavity) reconstruction has taken a significant step forward with a Netherlands-based research team's successful development of a gum tissue (gingival) substitute that can be used for reconstruction in the oral cavity. First trimester smoking linked to oral clefts Smoking during the first trimester of pregnancy is clearly linked with an increased risk of cleft lip in newborns. Moms' smoking linked to increased risk of birth defects Babies whose mothers smoked during pregnancy were more than twice as likely to have a cleft palate or lip as those whose mothers didn't, according to research results released today. Study finds genetic variant plays role in cleft lip University of Iowa researchers and collaborators have found, in a previously identified gene, a variation that likely contributes to one in five cases of isolated cleft lip. Genetic profile reveals susceptibility to cleft palate For the first time, researchers from the University of Pittsburgh School of Dental Medicine have identified a series of genetic mutations that appear to be linked to significant risk for cleft palate and other dental abnormalities. New insight into most common forebrain malformation St. Jude Children's Research Hospital scientists have identified one of the molecular mechanisms underlying the genetic brain malformation called holoprosencephaly (HPE). The findings not only yield insights into the most common developmental malformation of the anterior brain and face in newborns, but also help in understanding the intricate process by which the brain forms in the developing fetus. USC researchers identify alternate pathway that leads to palate development Researchers at the University Of Southern California School Of Dentistry have uncovered another clue behind the causes of cleft palate and the process that leads to palate formation. Lack of time on tummy shown to hinder achievement The American Physical Therapy Association (APTA) is urging parents and caregivers to ensure that babies get enough "tummy time" throughout the day while they are awake and supervised, in light of a recent survey of therapists who say they've noticed an increase in motor delays in infants who spend too much time on their backs while awake. More Cleft Palate Current Events and Cleft Palate News Articles |
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