Vitamin D protects cells from stress that can lead to cancerMay 14, 2008By inducing a specific gene to increase expression of a key enzyme, vitamin D protects healthy prostate cells from the damage and injuries that can lead to cancer, University of Rochester Medical Center researchers report. "Many epidemiological studies have suggested the beneficial properties of vitamin D," said Yi-Fen Lee, associate professor of urology at the Medical Center who led the research. "Our findings reflect what we see in those studies and demonstrate that vitamin D not only can be used as a therapy for prostate cancer, it can prevent prostate cancer from happening." The International Journal of Cancer published the findings in its June 15 issue. Lee and her research team discovered one mechanism involving vitamin D that protects cells from oxidative stress. The vitamin D used in the study is 1,25-hydroxylvitamin D3, the most potent and active form of vitamin D in the human body. Nonmalignant human prostate epithelial cells also were used. Normal metabolism in cells generates reactive oxygen species (ROS), molecules of peroxide, for example, or so-called free radicals. These substances can play a role in cell signaling and even kill bacteria. Exposure to some chemicals or forms of radiation can produce high levels of ROS that can damage DNA and play a significant role in speeding aging or causing cancer. Lee found that vitamin D links with a gene known as G6PD, increasing its activity and the production of an enzyme called glucose-6-phosphate dehydrogenase. Increased activity of the enzyme clears cells of ROS, the molecules that can damage and injure cells. "If you reduce DNA damage, you reduce the risk of cancer or aging," Lee said. "Our study adds one more beneficial effect of taking a vitamin D supplement. Taking a supplement is especially important for senior citizens and others who might have less circulation of vitamin D, and for people who live and work areas where there is less sunshine." Large amounts of vitamin D should not be taken without medical supervision, she said. The G6PD pathway is one of the mechanisms vitamin D uses, Lee said. The researchers did not find any similar activity in prostate cancer cells. "Vitamin D does not protect cancer cells from injury or damage, which is good," Lee said. University of Rochester Medical Center |
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| Related Vitamin D Current Events and Vitamin D News Articles Multiple health concerns surface as winter, vitamin D deficiences arrive A string of recent discoveries about the multiple health benefits of vitamin D has renewed interest in this multi-purpose nutrient, increased awareness of the huge numbers of people who are deficient in it, spurred research and even led to an appreciation of it as "nature's antibiotic." Heart and bone damage from low vitamin D tied to declines in sex hormones Researchers at Johns Hopkins are reporting what is believed to be the first conclusive evidence in men that the long-term ill effects of vitamin D deficiency are amplified by lower levels of the key sex hormone estrogen, but not testosterone. New study links vitamin D deficiency to cardiovascular disease and death While mothers have known that feeding their kids milk builds strong bones, a new study by researchers at the Heart Institute at Intermountain Medical Center in Salt Lake City suggests that Vitamin D contributes to a strong and healthy heart as well - and that inadequate levels of the vitamin may significantly increase a person's risk of stroke, heart disease, and death, even among people who've never had heart disease. Lactose intolerance rates may be significantly lower than previously believed Prevalence of lactose intolerance may be far lower than previously estimated, according to a study in the latest issue of Nutrition Today. Nation's hip fracture rate could drop 25 percent with aggressive osteoporosis prevention Aggressively managing patients at risk for osteoporosis could reduce the hip fracture rate in the United States by 25 percent, according to a Kaiser Permanente study published in the November issue of the Journal of Bone & Joint Surgery. Neurologists Investigate Possible New Underlying Cause of MS Neurologists at the University at Buffalo are beginning a research study that could overturn the prevailing wisdom on the cause of multiple sclerosis (MS). Latest analysis confirms suboptimal vitamin D levels in millions of US children Millions of children in the United States between the ages of 1 and 11 may suffer from suboptimal levels of vitamin D, according to a large nationally representative study published in the November issue of Pediatrics, accompanied by an editorial. Women with breast cancer have low vitamin D levels Women with breast cancer should be given high doses of vitamin D because a majority of them are likely to have low levels of vitamin D, which could contribute to decreased bone mass and greater risk of fractures, according to scientists at the University of Rochester Medical Center. New link found between osteoporosis and coeliac disease People with coeliac disease may develop osteoporosis because their immune system attacks their bone tissue, a new study has shown. Insufficient levels of vitamin D puts elderly at increased risk of dying from heart disease A new study by researchers at the University of Colorado Denver and Massachusetts General Hospital (MGH) shows vitamin D plays a vital role in reducing the risk of death associated with older age. More Vitamin D Current Events and Vitamin D News Articles |
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